scholarly journals Thyroid hormone receptor agonists to reduce cholesterol levels?

2012 ◽  
Vol 9 (1) ◽  
pp. 3-3
Author(s):  
Fiona Mitchell
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Agonists ◽  
Cholesterol Levels

scholarly journals Hypercholesterolemia in Two Siblings with Resistance to Thyroid Hormones Due to Disease-Causing Variant in Thyroid Hormone Receptor (THRB) Gene

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 699
Author(s):  
Maja Pajek ◽  
Magdalena Avbelj Stefanija ◽  
Katarina Trebusak Podkrajsek ◽  
Jasna Suput Omladic ◽  
Mojca Zerjav Tansek ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Pathogenic Mutation ◽  
Laboratory Findings ◽  
Cholesterol Levels ◽  
Resistance To Thyroid Hormones ◽  
Hormonal Resistance ◽  
Disease Variant

Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by a reduced response of target tissues to thyroid hormones. In 85% of cases, a pathogenic mutation in the thyroid hormone receptor beta (THRB) gene is found. The clinical picture of RTHβ is very diverse; the most common findings are goiter and tachycardia, but the patients might be clinically euthyroid. The laboratory findings are almost pathognomonic with elevated free thyroxin (fT4) levels and high or normal thyrotropin (TSH) levels; free triiodothyronin (fT3) levels may also be elevated. We present three siblings with THRB mutation (heterozygous disease-variant c.727C>T, p.Arg243Trp); two of them also had hypercholesterolemia, while all three had several other clinical characteristics of RTHβ. This is the first description of the known Slovenian cases with RTHβ due to the pathogenic mutation in the THRB gene. Hypercholesterolemia might be etiologically related with RTHβ, since the severity of hormonal resistance varies among different tissues and hypercholesterolemia in patients with THRB variants might indicate the relatively hypothyroid state of the liver. We suggest that cholesterol levels are measured in all RTHβ patients.

scholarly journals The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122987 ◽  
Author(s):  
Alexandro J. Martagón ◽  
Jean Z. Lin ◽  
Stephanie L. Cimini ◽  
Paul Webb ◽  
Kevin J. Phillips
Keyword(s):  
Insulin Sensitivity ◽  
Thyroid Hormone ◽  
Hepatic Steatosis ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Agonists

scholarly journals Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells

2007 ◽  
Vol 115 (11) ◽  
pp. 1623-1630 ◽  
Author(s):  
Kelly J. Gauger ◽  
Stefanie Giera ◽  
David S. Sharlin ◽  
Ruby Bansal ◽  
Eric Iannacone ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Polychlorinated Biphenyls ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Gh3 Cells ◽  
Cytochrome P4501a1 ◽  
Receptor Agonists ◽  
Rat Pituitary

scholarly journals Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists

2018 ◽  
Vol 77 ◽  
pp. 80-93 ◽  
Author(s):  
Derik E. Haggard ◽  
Pamela D. Noyes ◽  
Katrina M. Waters ◽  
Robert L. Tanguay
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Agonists
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