The full repertoire of humanized antibodies

2014 ◽  
Vol 13 (5) ◽  
pp. 336-336
Author(s):  
Charlotte Harrison
Keyword(s):  
Humanized Antibodies

scholarly journals Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161446 ◽  
Author(s):  
Sebastian Miethe ◽  
Christelle Mazuet ◽  
Yvonne Liu ◽  
Robert Tierney ◽  
Christine Rasetti-Escargueil ◽  
...  
Keyword(s):  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Humanized Antibodies

Humanized Antibodies

1998 ◽  
pp. 1139-1144
Author(s):  
William J. Harris
Keyword(s):  
Humanized Antibodies

Therapy of metastatic breast cancer with humanized antibodies against the HER2 receptor protein

1999 ◽  
Vol 125 (8-9) ◽  
pp. 520-524 ◽  
Author(s):  
G. Schaller ◽  
N. Bangemann ◽  
C. Becker ◽  
H. Bühler ◽  
F. Opri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Receptor Protein ◽  
Her2 Receptor ◽  
Humanized Antibodies

scholarly journals Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodies

Leukemia ◽  
2013 ◽  
Vol 27 (6) ◽  
pp. 1263-1274 ◽  
Author(s):  
K Matlawska-Wasowska ◽  
E Ward ◽  
S Stevens ◽  
Y Wang ◽  
R Herbst ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Humanized Antibodies

scholarly journals Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses

2011 ◽  
Vol 55 (4) ◽  
pp. 1349-1357 ◽  
Author(s):  
Qingbing Zheng ◽  
Lin Xia ◽  
Wai Lan Wu ◽  
Zhenhua Zheng ◽  
Yongting Huo ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
H5n1 Virus ◽  
Influenza Viruses ◽  
Chimeric Antibody ◽  
Dependent Manner ◽  
Variable Regions ◽  
H5n1 Influenza ◽  
Therapeutic Regime ◽  
Humanized Antibodies

ABSTRACTHighly pathogenic H5N1 virus infection causes severe disease and a high rate of fatality in humans. Development of humanized monoclonal antibodies may provide an efficient therapeutic regime for H5N1 virus infection. In the present study, broadly cross-reactive monoclonal antibodies (MAbs) derived from mice were humanized to minimize immunogenicity. One chimeric antibody (cAb) and seven humanized antibodies (hAbs) were constructed. These antibodies retained broad-spectrum reactivity to H5N1 viruses, binding to recombinant H5-subtype HA1 molecules expressed in CHO cells in a dose-dependent manner and exhibiting similar reactivities against antigenically distinct H5N1 viruses in hemagglutination inhibition (HI) assays. One humanized antibody, 37 hAb, showed HI and neutralization activities comparable to that of the parental murine antibody, 13D4 MAb, while the other six antibodies were less reactive to H5N1 viruses. Analysis of amino acid sequences in the variable region frameworks of the seven humanized antibodies found that Q5 and Y27 in the VH region are highly conserved murine residues. Comparison of the three-dimensional structures derived from the variable regions of MAbs 37 hAb, H1202-34, and 13D4 revealed that residue substitutions at sites 70 and 46 may be the major cause for the observed differences in binding affinity. Examination of the chimeric antibody and one of the humanized antibodies, 37 hAb, showed that both antibodies offered postinfection protection against lethal challenge with antigenically diverse H5N1 viruses in the mouse model. Chimeric and humanized antibodies which retain the broadly reactive and protective properties of murine H5-specific monoclonal antibodies have great potential for use in the treatment of human H5N1 infection.

scholarly journals Humanized antibodies for antiviral therapy.

1991 ◽  
Vol 88 (7) ◽  
pp. 2869-2873 ◽  
Author(s):  
M. S. Co ◽  
M. Deschamps ◽  
R. J. Whitley ◽  
C. Queen
Keyword(s):  
Antiviral Therapy ◽  
Humanized Antibodies

scholarly journals Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

2017 ◽  
Vol 23 (17) ◽  
pp. 5267-5280 ◽  
Author(s):  
Alexandre Prieur ◽  
Monica Cappellini ◽  
Guillaume Habif ◽  
Marie-Paule Lefranc ◽  
Thibault Mazard ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Pathway ◽  
Potential Treatment ◽  
Humanized Antibodies
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