scholarly journals Microtubule-binding agents: a dynamic field of cancer therapeutics

2010 ◽  
Vol 9 (10) ◽  
pp. 790-803 ◽  
Author(s):  
Charles Dumontet ◽  
Mary Ann Jordan
Keyword(s):  
Cancer Therapeutics ◽  
Microtubule Binding ◽  
Dynamic Field ◽  
Binding Agents

1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents

2010 ◽  
Vol 18 (18) ◽  
pp. 6874-6885 ◽  
Author(s):  
Kristin Odlo ◽  
Jérémie Fournier-Dit-Chabert ◽  
Sylvie Ducki ◽  
Osman A.B.S.M. Gani ◽  
Ingebrigt Sylte ◽  
...  
Keyword(s):  
Microtubule Binding ◽  
Binding Agents

Hepatic processing of cholecystokinin peptides. II. Cellular metabolism, transport, and biliary excretion

1986 ◽  
Vol 250 (3) ◽  
pp. G350-G356 ◽  
Author(s):  
G. J. Gores ◽  
L. J. Miller ◽  
N. F. LaRusso
Keyword(s):  
Biliary Excretion ◽  
High Performance ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Microtubule Binding ◽  
Cholecystokinin Octapeptide ◽  
Radiolabeled Peptides ◽  
Binding Agents ◽  
Specific Manner ◽  
Insight Into

We have shown that radiolabeled cholecystokinin octapeptide (CCK-8), CCK-8-desulfate, and CCK-4 are extracted by the liver in a structurally specific manner. Thus, we studied the fate of the extracted radiolabeled peptides by quantitating biliary excretion and determining the nature of the metabolites in bile. There was rapid biliary excretion of labeled CCK-8, CCK-8-desulfate, and CCK-4 by the isolated, perfused rat liver; greater than 75% of the extracted dose and greater than 20% of the injected dose appeared in bile within 20 min after a single pass across the liver. By means of high-performance liquid chromatography and immunoprecipitation, we showed that CCK-8-desulfate and CCK-4 appeared in bile in completely metabolized forms. In contrast, for CCK-8, approximately 20% of the major forms of the label in bile was intact labeled octapeptide. To gain insight into the subcellular sites of metabolism and transhepatic transport of CCK-8, we also determined the effects of taurocholate, lysosomotropic agents, and microtubule binding agents on biliary excretion. Taurocholate had no effect on the percentage of the extracted label excreted into bile. Neither the percentage of the extracted label excreted into bile. Neither lysosmotropic agent, leupeptin, nor chloroquine affected the percentage of the extracted label or the nature of the metabolites appearing in bile. Two microtubule binding agents, vinblastine and colchicine, also did not affect the percentage of the extracted label appearing in bile.(ABSTRACT TRUNCATED AT 250 WORDS)

Synthesis, cytotoxic evaluation, and molecular docking study of 4,5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents

2013 ◽  
Vol 23 (3) ◽  
pp. 1465-1473 ◽  
Author(s):  
Marjan Salehi ◽  
Seyed Nasser Ostad ◽  
Gholam Hossein Riazi ◽  
Amir Assadieskandar ◽  
Tayebeh Cheraghi-Shavi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Microtubule Binding ◽  
Binding Agents

In Search of Novel Cancer Therapeutics: Assessing the NCI Natural Product Library against Ten Anti-Apoptotic Protein Targets

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
DB Divlianska ◽  
AE Wright ◽  
S Francis ◽  
MA Walters ◽  
CE Salomon ◽  
...  
Keyword(s):  
Natural Product ◽  
Cancer Therapeutics ◽  
Protein Targets ◽  
Apoptotic Protein ◽  
Natural Product Library

Calmodulin binding agents from selected fungal metabolites

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Del Valle ◽  
M González-Andrade ◽  
M Figueroa ◽  
R Mata
Keyword(s):  
Fungal Metabolites ◽  
Calmodulin Binding ◽  
Binding Agents

Src Kinase Inhibitors: Promising Cancer Therapeutics?

2012 ◽  
Vol 17 (2) ◽  
pp. 145-159 ◽  
Author(s):  
Helen Creedon ◽  
Valerie G . Brunton
Keyword(s):  
Kinase Inhibitors ◽  
Src Kinase ◽  
Cancer Therapeutics
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