The importance of mitochondrial tRNA

2015 ◽  
Vol 15 (8) ◽  
pp. 456-456
Author(s):  
M. Teresa Villanueva
Keyword(s):  
Mitochondrial Trna

The Possible Common Origin of tRNA and 5S rRNA

1983 ◽  
Vol 38 (5-6) ◽  
pp. 501-504 ◽  
Author(s):  
Mária Ujhelyi
Keyword(s):  
Common Ancestor ◽  
Common Origin ◽  
5S Rrna ◽  
Mitochondrial Trna ◽  
Trna Molecule ◽  
The Common

Seryl tRNA (anticodon GCU) from mammalian mito­chondria shows in comparison to other mitochondrial tRNAs additional special features differing from the generalized tRNA model. When arranged in the tradi­tional cloverleaf form, eight bases fall within the TΨC loop, and the entire dihydrouridine loop is lacking. This seryl tRNA molecule is therefore shorter than other tRNAs. It was originally thought to represent a mito­chondrial analogon of 5 S rRNA and its precise classifica­tion is still disputed. The present studies suggest that this mitochondrial tRNA represents a fossil molecule which is related to the common ancestor of the present tRNA and 5 S rRNA molecules.

scholarly journals Heterogenous Point Mutations in the Mitochondrial tRNA Ser(UCN) Precursor Coexisting with the A1555G Mutation in Deaf Students from Mongolia

1999 ◽  
Vol 65 (6) ◽  
pp. 1803-1806 ◽  
Author(s):  
Arti Pandya ◽  
Xia-Juan Xia ◽  
Raadnabazar Erdenetungalag ◽  
Michael Amendola ◽  
Barbara Landa ◽  
...  
Keyword(s):  
Point Mutations ◽  
Mitochondrial Trna ◽  
Deaf Students ◽  
A1555g Mutation

A novel point mutation in the mitochondrial tRNA(Trp) gene produces late-onset encephalomyopathy, plus additional features

2010 ◽  
Vol 297 (1-2) ◽  
pp. 105-108 ◽  
Author(s):  
Edoardo Malfatti ◽  
Elena Cardaioli ◽  
Carla Battisti ◽  
Paola Da Pozzo ◽  
Alessandro Malandrini ◽  
...  
Keyword(s):  
Point Mutation ◽  
Late Onset ◽  
Mitochondrial Trna

scholarly journals Nuclear and mitochondrial tRNA-lookalikes in the human genome

2014 ◽  
Vol 5 ◽  
Author(s):  
Aristeidis G. Telonis ◽  
Phillipe Loher ◽  
Yohei Kirino ◽  
Isidore Rigoutsos
Keyword(s):  
Human Genome ◽  
Mitochondrial Trna

scholarly journals Three mitochondrial tRNA genes fromArabidopsis thaliana: evidence for the conversion of a tRNAPhegene into a tRNATyrgene

1989 ◽  
Vol 17 (7) ◽  
pp. 2613-2622 ◽  
Author(s):  
Hsu-Ching Chen ◽  
Henri Wintz ◽  
Jacques-Henry Weil ◽  
Datta T.N. Pillay
Keyword(s):  
Trna Genes ◽  
Mitochondrial Trna ◽  
Mitochondrial Trna Genes

Characterization of mutant mitochondrial plasmids of Neurospora spp. that have incorporated tRNAs by reverse transcription

1989 ◽  
Vol 9 (2) ◽  
pp. 678-691
Author(s):  
R A Akins ◽  
R L Kelley ◽  
A M Lambowitz
Keyword(s):  
Mitochondrial Dna ◽  
Reverse Transcription ◽  
Transcription Initiation ◽  
Consensus Sequence ◽  
Trna Genes ◽  
Wild Type ◽  
Mitochondrial Trna ◽  
Mitochondrial Plasmids ◽  
Circular Dnas ◽  
Mitochondrial Introns

The Mauriceville and Varkud mitochondrial plasmids of Neurospora spp. are closely related, closed-circular DNAs (3.6 and 3.7 kilobases, respectively) whose nucleotide sequences and genetic organization suggest relationships to mitochondrial introns and retroelements. We have characterized nine suppressive mutants of these plasmids that outcompete mitochondrial DNA and lead to impaired growth. All nine suppressive plasmids contain small insertions, corresponding to or including a mitochondrial tRNA (tRNATrp, tRNAGly, or tRNAVal) or a tRNA-like sequence. The insertions are located at the position corresponding to the 5' end of the major plasmid transcript or 24 nucleotides downstream near a cognate of the sequence at the major 5' RNA end. The structure of the suppressive plasmids suggests that the tRNAs were inserted via an RNA intermediate. The 3' end of the wild-type plasmid transcript can itself be folded into a secondary structure which has tRNA-like characteristics, similar to the tRNA-like structures at the 3' ends of plant viral RNAs. This structure may play a role in replication of the plasmids by reverse transcription. Major transcripts of the suppressive plasmids begin at the 5' end of the inserted mitochondrial tRNA sequence and are present in 25- to 100-fold-higher concentrations than are transcripts of wild-type plasmids. Mapping of 5' RNA ends within the inserted mtDNA sequences identifies a short consensus sequence (PuNPuAG) which is present at the 5' ends of a subset of mitochondrial tRNA genes. This sequence, together with sequences immediately upstream in the plasmids, forms a longer consensus sequence, which is similar to sequences at transcription initiation sites in Neurospora mitochondrial DNA. The suppressive behavior of the plasmids is likely to be directly related to the insertion of tRNAs leading to overproduction of plasmid transcripts.

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