Topoisomerase-mediated chromosomal break repair: an emerging player in many games

2015 ◽  
Vol 15 (3) ◽  
pp. 137-151 ◽  
Author(s):  
Mohamed E. Ashour ◽  
Reham Atteya ◽  
Sherif F. El-Khamisy
Keyword(s):  
Break Repair ◽  
Chromosomal Break

scholarly journals C9orf72 expansion disrupts ATM-mediated chromosomal break repair

2017 ◽  
Vol 20 (9) ◽  
pp. 1225-1235 ◽  
Author(s):  
Callum Walker ◽  
Saul Herranz-Martin ◽  
Evangelia Karyka ◽  
Chunyan Liao ◽  
Katherine Lewis ◽  
...  
Keyword(s):  
C9orf72 Expansion ◽  
Break Repair ◽  
Chromosomal Break

scholarly journals UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis

Cell Reports ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 3352-3365 ◽  
Author(s):  
Chunyan Liao ◽  
Ryan Beveridge ◽  
Jessica J.R. Hudson ◽  
Jacob D. Parker ◽  
Shih-Chieh Chiang ◽  
...  
Keyword(s):  
Break Repair ◽  
Chromosomal Break

scholarly journals Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

PLoS Genetics ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. e1008319 ◽  
Author(s):  
Andrew A. Kelso ◽  
Felicia Wednesday Lopezcolorado ◽  
Ragini Bhargava ◽  
Jeremy M. Stark
Keyword(s):  
Stress Response ◽  
Replication Stress ◽  
Break Repair ◽  
Chromosomal Break

Bestimmung der DNA-Schädigung in vitro

2010 ◽  
Vol 49 (S 01) ◽  
pp. S64-S68
Author(s):  
E. Dikomey
Keyword(s):  
Dna Damage ◽  
Cell Lines ◽  
Chromosome Aberrations ◽  
Genetic Factors ◽  
Double Strand Breaks ◽  
Strand Breaks ◽  
Cell Inactivation ◽  
Repair Mechanisms ◽  
Break Repair

SummaryIonising irradiation acts primarily via induction of DNA damage, among which doublestrand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of doublestrand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about doublestrand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.

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