Chemical synthesis of membrane proteins by the removable backbone modification method

2017 ◽  
Vol 12 (12) ◽  
pp. 2554-2569 ◽  
Author(s):  
Shan Tang ◽  
Chao Zuo ◽  
Dong-Liang Huang ◽  
Xiao-Ying Cai ◽  
Long-Hua Zhang ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Modification Method ◽  
Backbone Modification

Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins

2017 ◽  
Vol 50 (5) ◽  
pp. 1143-1153 ◽  
Author(s):  
Jia-Bin Li ◽  
Shan Tang ◽  
Ji-Shen Zheng ◽  
Chang-Lin Tian ◽  
Lei Liu
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Modification Method ◽  
Backbone Modification

Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification

2016 ◽  
Vol 138 (10) ◽  
pp. 3553-3561 ◽  
Author(s):  
Ji-Shen Zheng ◽  
Yao He ◽  
Chao Zuo ◽  
Xiao-Ying Cai ◽  
Shan Tang ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Backbone Modification ◽  
General Method

scholarly journals Chemical Synthesis of Native S‐Palmitoylated Membrane Proteins through Removable‐Backbone‐Modification‐Assisted Ser/Thr Ligation

2020 ◽  
Vol 59 (13) ◽  
pp. 5178-5184 ◽  
Author(s):  
Dong‐Liang Huang ◽  
Cédric Montigny ◽  
Yong Zheng ◽  
Veronica Beswick ◽  
Ying Li ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Backbone Modification

scholarly journals Chemical Synthesis of Native S‐Palmitoylated Membrane Proteins through Removable‐Backbone‐Modification‐Assisted Ser/Thr Ligation

2020 ◽  
Vol 132 (13) ◽  
pp. 5216-5222
Author(s):  
Dong‐Liang Huang ◽  
Cédric Montigny ◽  
Yong Zheng ◽  
Veronica Beswick ◽  
Ying Li ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Backbone Modification

ChemInform Abstract: Chemical Synthesis of Integral Membrane Proteins: Methods and Applications

ChemInform ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. no-no
Author(s):  
Fei Shen ◽  
Yi-Chao Huang ◽  
Shan Tang ◽  
Yong-Xiang Chen ◽  
Lei Liu
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Integral Membrane Proteins

Chemical synthesis and biophysical applications of membrane proteins

2014 ◽  
Vol 21 (7) ◽  
pp. 540-549 ◽  
Author(s):  
Chao Zuo ◽  
Shan Tang ◽  
Ji-Shen Zheng
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis

Membrane Proteins: Chemical Synthesis and Ligation

2017 ◽  
pp. 269-284 ◽  
Author(s):  
Marc Dittman ◽  
Martin Engelhard
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis

scholarly journals Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications

2015 ◽  
Vol 32 (5-8) ◽  
pp. 139-155 ◽  
Author(s):  
Kazumi Hiruma-Shimizu ◽  
Hiroki Shimizu ◽  
Gary S. Thompson ◽  
Arnout P. Kalverda ◽  
Simon G. Patching
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Functional Studies

scholarly journals Nonenzymatic synthesis of anomerically pure, mannosyl-based molecular probes for scramblase identification studies

2020 ◽  
Vol 16 ◽  
pp. 1732-1739
Author(s):  
Giovanni Picca ◽  
Markus Probst ◽  
Simon M Langenegger ◽  
Oleg Khorev ◽  
Peter Bütikofer ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Molecular Probes ◽  
Protein Glycosylation ◽  
Pure Form ◽  
Short Chain ◽  
Biological Pathway ◽  
Naturally Occurring ◽  
Phosphoramidite Chemistry ◽  
Straightforward Approach

The chemical synthesis of molecular probes to identify and study membrane proteins involved in the biological pathway of protein glycosylation is described. Two short-chain glycolipid analogs that mimic the naturally occurring substrate mannosyl phosphoryl dolichol exhibit either photoreactive and clickable properties or allow the use of a fluorescence readout. Both probes consist of a hydrophilic mannose headgroup that is linked to a citronellol derivative via a phosphodiester bridge. Moreover, a novel phosphoramidite chemistry-based method offers a straightforward approach for the non-enzymatic incorporation of the saccharide moiety in an anomerically pure form.

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