scholarly journals A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

2014 ◽  
Vol 9 (12) ◽  
pp. 2755-2770 ◽  
Author(s):  
Michelle Kim ◽  
Nina N Hosmane ◽  
C Korin Bullen ◽  
Adam Capoferri ◽  
Hung-Chih Yang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Model ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Hiv 1

Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during highly active antiretroviral therapy

AIDS ◽  
1998 ◽  
Vol 12 (18) ◽  
pp. F235-F240 ◽  
Author(s):  
Stefan Kostense ◽  
Frank M. Raaphorst ◽  
Daan W. Notermans ◽  
Jeanine Joling ◽  
Berend Hooibrink ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Receptor ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Cell Repopulation ◽  
Hiv 1

CD4+ T cell receptor repertoire perturbations in HIV-1 infection: Association with plasma viremia and disease progression

2006 ◽  
Vol 119 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Uma Malhotra ◽  
Claire Huntsberry ◽  
Sarah Holte ◽  
Jean Lee ◽  
Lawrence Corey ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Plasma Viremia ◽  
Receptor Repertoire ◽  
T Cell Receptor Repertoire ◽  
Hiv 1 ◽  
Cell Receptor Repertoire

Normal CD4 T-cell receptor repertoire in tonsillar tissue despite perturbed repertoire in peripheral blood in HIV-1 infected individuals

AIDS ◽  
1999 ◽  
Vol 13 (18) ◽  
pp. 2507-2513 ◽  
Author(s):  
Emiliano N. Mugnaini ◽  
Anette M. Syversen ◽  
Mette Sannes ◽  
Atle Freng ◽  
Jan E. Brinchmann
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Peripheral Blood ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Tonsillar Tissue ◽  
Receptor Repertoire ◽  
T Cell Receptor Repertoire ◽  
Hiv 1 ◽  
Cell Receptor Repertoire

scholarly journals Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse

2009 ◽  
Vol 83 (21) ◽  
pp. 11341-11355 ◽  
Author(s):  
Gaia Vasiliver-Shamis ◽  
Michael W. Cho ◽  
Catarina E. Hioe ◽  
Michael L. Dustin
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Infected Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Virological Synapse ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Cell-to-cell transmission of human immunodeficiency virus type 1 (HIV-1) occurs via a virological synapse (VS), a tight cell-cell junction formed between HIV-infected cells and target cells in which the HIV-1-infected cell polarizes and releases virions toward the noninfected target cell in a gp120- and intercellular adhesion molecule 1 (ICAM-1)-dependent process. The response of the target cell has been less studied. We utilized supported planar bilayers presenting gp120 and ICAM-1 as a reductionist model for the infected-cell membrane and investigated its effect on the target CD4 T cell. This study shows that HIV-1 gp120 interaction with its receptors is initially organized into microclusters that undergo F-actin-dependent consolidation into a central supramolecular activation complex (cSMAC). Src kinases are active in both gp120 microclusters and in the VS cSMAC. The early T-cell receptor (TCR) signaling machinery is partially activated at the VS, and signaling does not propagate to trigger Ca2+ elevation or increase CD69 expression. However, these partial TCR signals act locally to create an F-actin-depleted zone. We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events.

Normalization of the CD4 T cell receptor repertoire after evolution of syncytium-inducing HIV-1 variants

AIDS ◽  
2000 ◽  
Vol 14 (3) ◽  
pp. 330-331 ◽  
Author(s):  
Stefan Kostense ◽  
Esmeralda Krop ◽  
Hetty Blaak ◽  
Hanneke Schuitemaker ◽  
Frank Miedema
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Receptor Repertoire ◽  
T Cell Receptor Repertoire ◽  
Hiv 1 ◽  
Cell Receptor Repertoire

T cell receptor γδ repertoire in HIV-1-infected individuals

1994 ◽  
Vol 24 (12) ◽  
pp. 3044-3049 ◽  
Author(s):  
Thomas Hinz ◽  
Daniela Wesch ◽  
Klaus Friese ◽  
Anne Reckziegel ◽  
Bernhard Arden ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Hiv 1

scholarly journals Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

2008 ◽  
Vol 14 (12) ◽  
pp. 1390-1395 ◽  
Author(s):  
Angel Varela-Rohena ◽  
Peter E Molloy ◽  
Steven M Dunn ◽  
Yi Li ◽  
Megan M Suhoski ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Immune Escape ◽  
Cell Receptor ◽  
Hiv 1

HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling

1995 ◽  
Vol 25 (5) ◽  
pp. 1417-1425 ◽  
Author(s):  
Pascale Hubert ◽  
Georges Bismuth ◽  
Marie Körner ◽  
Patrice Debré
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Interactions ◽  
Glycoprotein Gp120 ◽  
Hiv 1
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