scholarly journals Genome-wide copy number analysis of single cells

2012 ◽  
Vol 7 (6) ◽  
pp. 1024-1041 ◽  
Author(s):  
Timour Baslan ◽  
Jude Kendall ◽  
Linda Rodgers ◽  
Hilary Cox ◽  
Mike Riggs ◽  
...  
Keyword(s):  
Copy Number ◽  
Single Cells ◽  
Copy Number Analysis ◽  
Genome Wide

scholarly journals Erratum: Corrigendum: Genome-wide copy number analysis of single cells

2016 ◽  
Vol 11 (3) ◽  
pp. 616-616 ◽  
Author(s):  
Timour Baslan ◽  
Jude Kendall ◽  
Linda Rodgers ◽  
Hilary Cox ◽  
Mike Riggs ◽  
...  
Keyword(s):  
Copy Number ◽  
Single Cells ◽  
Copy Number Analysis ◽  
Genome Wide

scholarly journals HiVA: an integrative wet- and dry-lab platform for haplotype and copy number analysis of single-cell genomes

2019 ◽  
Author(s):  
Masoud Zamani Esteki ◽  
Amin Ardeshirdavani ◽  
Daniel Alcaide ◽  
Heleen Masset ◽  
Jia Ding ◽  
...  
Keyword(s):  
Single Cell ◽  
Genetic Variants ◽  
Copy Number ◽  
Web Application ◽  
Single Cells ◽  
Genomic Data ◽  
Comprehensive Analysis ◽  
Whole Genome ◽  
Copy Number Analysis ◽  
Genome Wide

Haplotyping is imperative for comprehensive analysis of genomes, imputation of genetic variants and interpretation of error-prone single-cell genomic data. Here we present a novel sequencing-based approach for whole-genome SNP typing of single cells, and determine genome-wide haplotypes, the copy number of those haplotypes as well as the parental and segregational origin of chromosomal aberrations from sequencing- and array-based SNP landscapes of single cells. The analytical workflow is made available as an interactive web application HiVA (https://hiva.esat.kuleuven.be).

Abstract 1447: Investigating susceptibility to sporadic osteosarcoma by genome-wide copy number analysis

2012 ◽  
Author(s):  
Rinnat M. Porat ◽  
Ivan Pasic ◽  
Adan Shlien ◽  
Nalan Gokgoz ◽  
Irene Andrulis ◽  
...  
Keyword(s):  
Copy Number ◽  
Copy Number Analysis ◽  
Genome Wide

scholarly journals DNA Analysis by Restriction Enzyme (DARE) enables concurrent genomic and epigenomic characterization of single cells

2019 ◽  
Vol 47 (19) ◽  
pp. e122-e122
Author(s):  
Ramya Viswanathan ◽  
Elsie Cheruba ◽  
Lih Feng Cheow
Keyword(s):  
Dna Methylation ◽  
Restriction Enzyme ◽  
Copy Number ◽  
Dna Analysis ◽  
Whole Genome Amplification ◽  
Single Cells ◽  
Whole Genome ◽  
Copy Number Alterations ◽  
Genome Wide

Abstract Genome-wide profiling of copy number alterations and DNA methylation in single cells could enable detailed investigation into the genomic and epigenomic heterogeneity of complex cell populations. However, current methods to do this require complex sample processing and cleanup steps, lack consistency, or are biased in their genomic representation. Here, we describe a novel single-tube enzymatic method, DNA Analysis by Restriction Enzyme (DARE), to perform deterministic whole genome amplification while preserving DNA methylation information. This method was evaluated on low amounts of DNA and single cells, and provides accurate copy number aberration calling and representative DNA methylation measurement across the whole genome. Single-cell DARE is an attractive and scalable approach for concurrent genomic and epigenomic characterization of cells in a heterogeneous population.

scholarly journals Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains

2013 ◽  
Vol 41 (6) ◽  
pp. e66-e66 ◽  
Author(s):  
Niels Van der Aa ◽  
Jiqiu Cheng ◽  
Ligia Mateiu ◽  
Masoud Zamani Esteki ◽  
Parveen Kumar ◽  
...  
Keyword(s):  
Dna Replication ◽  
Copy Number ◽  
Single Cells ◽  
S Phase ◽  
Genome Wide

scholarly journals Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis

2005 ◽  
Vol 85 (9) ◽  
pp. 1118-1129 ◽  
Author(s):  
Hideaki Tanami ◽  
Hitoshi Tsuda ◽  
Satoshi Okabe ◽  
Takehisa Iwai ◽  
Kenichi Sugihara ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Copy Number ◽  
Cyclin D3 ◽  
Copy Number Analysis ◽  
Genome Wide
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