Immobilization of growth factors on solid supports for the modulation of stem cell fate

2010 ◽  
Vol 5 (6) ◽  
pp. 1042-1050 ◽  
Author(s):  
Tilo Pompe ◽  
Katrin Salchert ◽  
Kristin Alberti ◽  
Peter Zandstra ◽  
Carsten Werner
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Cell Fate ◽  
Solid Supports ◽  
Stem Cell Fate

scholarly journals Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Fei Xing ◽  
Lang Li ◽  
Changchun Zhou ◽  
Cheng Long ◽  
Lina Wu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Growth Factors ◽  
Cell Fate ◽  
Chemical Cues ◽  
Physical Factors ◽  
Stem Cell Fate ◽  
Physical And Chemical

It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.

scholarly journals Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors

2021 ◽  
Author(s):  
Kihak Gwon ◽  
Hye Jin Hong ◽  
Alan M. Gonzalez-Suarez ◽  
Michael Q. Slama ◽  
Daheui Choi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Cell Fate Decisions

scholarly journals Silk nanofiber hydrogels with tunable modulus to regulate nerve stem cell fate

2014 ◽  
Vol 2 (38) ◽  
pp. 6590-6600 ◽  
Author(s):  
ShuMeng Bai ◽  
WenMin Zhang ◽  
Qiang Lu ◽  
QuanHong Ma ◽  
David L. Kaplan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Cell Fate ◽  
Glial Differentiation ◽  
Neuron Differentiation ◽  
Stem Cell Fate

Silk nanofiber hydrogels with tunable modulus were prepared to facilitate neuron differentiation and inhibit glial differentiation without growth factors.

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