Experimental acute biliary pancreatitis induced by retrograde infusion of bile acids into the mouse pancreatic duct

2010 ◽  
Vol 5 (2) ◽  
pp. 335-341 ◽  
Author(s):  
George Perides ◽  
Gijs JD van Acker ◽  
Johanna M Laukkarinen ◽  
Michael L Steer
Keyword(s):  
Pancreatic Duct ◽  
Bile Acids ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

Bile Infection and Bile Acids Concentration in Bile in Acute Biliary Pancreatitis

2009 ◽  
Vol 81 (12) ◽  
Author(s):  
Jakub Zasada ◽  
Józefa Panek ◽  
Mirosław Dolecki ◽  
Zbigniew Biesiada ◽  
Marcin Dembiński
Keyword(s):  
Bile Acids ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

Sa1490 The Safety and Efficacy of Pancreatic Duct Stent Placement in the Emergency ERCP of Acute Biliary Pancreatitis

2016 ◽  
Vol 83 (5) ◽  
pp. AB271-AB272
Author(s):  
Hiroyuki Hisai ◽  
Tamaki Sakurai ◽  
Ryoya Seki ◽  
Yutaka Koshiba ◽  
Yusuke Kanari ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Stent Placement ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis ◽  
Safety And Efficacy ◽  
Pancreatic Duct Stent

Acute pancreatitis in rats: effects of sodium taurocholate, CCK-8, and Sec on pancreatic microcirculation

1997 ◽  
Vol 272 (2) ◽  
pp. G310-G320 ◽  
Author(s):  
T. Plusczyk ◽  
S. Westermann ◽  
D. Rathgeb ◽  
G. Feifel
Keyword(s):  
Blood Flow ◽  
Pancreatic Duct ◽  
Capillary Permeability ◽  
Sodium Taurocholate ◽  
Capillary Density ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

With use of in vivo microscopy, pancreatic duct permeability, red blood cell (RBC) velocities, functional capillary density (FCD), and overall changes in capillary blood flow (perfusion index) were estimated after intraductal infusion of sodium taurocholate (0.8 ml, 4%) alone or in combination with systemic administration of cholecystokinin (CCK, 0.3 microg/100 g body wt) or secretin (Sec, 10 microg/100 g body wt). Sodium taurocholate mediated a significant increase in pancreatic duct and capillary permeability within 105 +/- 26 s followed by a transient decrease in RBC velocities and a sustained decrease in FCD, which were paralleled by dramatic flow heterogeneity. Therefore, a significant reduction in overall capillary blood flow was calculated. CCK stimulation aggravated the microcirculatory failure due to a decrease in RBC velocities, which was accompanied by an increase in acinar cellular necrosis. Sec stimulation attenuated microcirculatory failure due to a more moderate reduction of FCD. The enhanced pancreatic duct and capillary permeability, which enables free diffusion of pancreatic digestive enzymes into the parenchyma, is the initiating event in acute biliary pancreatitis, causing microcirculatory failure and tissue damage. The microcirculatory changes are secondary and a propagating factor for the development of acini necrosis. Stimulation with CCK worsened the course of acute biliary pancreatitis.

The safety and efficacy of pancreatic duct stent placement in the emergency ERCP of acute biliary pancreatitis

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S49
Author(s):  
Hiroyuki Hisai ◽  
Tamaki Sakurai ◽  
Ryoya Seki ◽  
Yutaka Koshiba ◽  
Yusuke Kanari ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Stent Placement ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis ◽  
Safety And Efficacy ◽  
Pancreatic Duct Stent

scholarly journals A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate

Gut ◽  
2007 ◽  
Vol 56 (11) ◽  
pp. 1590-1598 ◽  
Author(s):  
J. M Laukkarinen ◽  
G. J D Van Acker ◽  
E. R Weiss ◽  
M. L Steer ◽  
G. Perides
Keyword(s):  
Mouse Model ◽  
Pancreatic Duct ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis
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