scholarly journals On the social induction of Alzheimer's disease: An index theorem aging model for amyloid formation

2011 ◽  
Author(s):  
Rodrick Wallace ◽  
Deborah Wallace
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Index Theorem ◽  
Amyloid Formation ◽  
Aging Model ◽  
The Social

Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study

2018 ◽  
Vol 30 (8) ◽  
pp. 1109-1117 ◽  
Author(s):  
Jun Li ◽  
Matteo Cesari ◽  
Natalia Del Campo ◽  
Sandrine Andrieu ◽  
Birong Dong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Self Report ◽  
Personal Life ◽  
Diabetic Patients ◽  
Psychological Burden ◽  
Factorial Model ◽  
The Social ◽  
Significant Difference ◽  
The Impact

ABSTRACTBackground:To estimate the impact of comorbid diabetes on caregiver stress in Alzheimer's disease (AD) patients from the Impact of Cholinergic Treatment Use (ICTUS) study.Methods:Using the Data from the ICTUS study, diabetes mellitus (DM) was recorded at baseline and caregiver burden was assessed twice per year using the Zarit Burden Interview (ZBI) scale. The three-factorial model of ZBI (the effect on the social and personal life of caregivers, the psychological burden and the feelings of guilt) was adopted. Linear mixed models were used to examine the relation between DM and the scores of ZBI.Results:The present analyses were conducted on 1,264 AD subjects. A total of 156 patients (12.3%) had DM with taking antidiabetic medication and/or self-report of a history. At baseline, the caregivers of patients with or without DM had similar ZBI global scores and similar scores of three different factors of ZBI. Unadjusted and adjusted models both indicated that ZBI global score increased over a 24-month follow-up without significant effect of DM. Similarly, unadjusted model showed that DM was not determining any significant difference in the score of any factor. However, adjusted model indicated that in diabetic patients, the scores of the social and personal life of caregivers and the psychological burden increased more slowly than those in non-diabetic patients (p = 0.04 and 0.01, respectively).Conclusions:DM may affect the caregivers’ daily social and personal life and psychological burden in AD patients. It is necessary for further research.

scholarly journals Home-Based Care for People with Alzheimer’s Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions

2020 ◽  
Vol 17 (24) ◽  
pp. 9303
Author(s):  
Atiqur sm-Rahman ◽  
Chih Hung Lo ◽  
Azra Ramic ◽  
Yasmin Jahan
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Supporting Evidence ◽  
Psychological Issues ◽  
Home Based ◽  
The Social ◽  
Novel Coronavirus ◽  
Home Based Care ◽  
The Impact

There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer’s disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.

Photo-oxygenation inhibits tau amyloid formation

2019 ◽  
Vol 55 (44) ◽  
pp. 6165-6168 ◽  
Author(s):  
Takanobu Suzuki ◽  
Yukiko Hori ◽  
Taka Sawazaki ◽  
Yusuke Shimizu ◽  
Yu Nemoto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Therapeutic Strategy ◽  
Fibril Formation ◽  
Amyloid Formation

Amyloid-selective catalytic photo-oxygenation of the tau protein is a possible therapeutic strategy for Alzheimer's disease, via the inhibition of tau fibril formation.

Use of antidepressants among community-dwelling persons with Alzheimer's disease: a nationwide register-based study

2014 ◽  
Vol 27 (4) ◽  
pp. 669-672 ◽  
Author(s):  
Marja-Liisa Laitinen ◽  
Eija Lönnroos ◽  
J. Simon Bell ◽  
Piia Lavikainen ◽  
Raimo Sulkava ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Insurance ◽  
Conditional Logistic Regression ◽  
Community Dwelling ◽  
Matched Pairs ◽  
The Social ◽  
High Prevalence ◽  
Region Of Residence ◽  
Antidepressant Use

ABSTRACTBackground:Antidepressants are used to treat depression and behavioral symptoms in Alzheimer's disease (AD), although their effectiveness has been questioned and evidence about the risks is accumulating. The objective of this study was to compare antidepressant use among persons with and without AD in Finland.Methods:The Social Insurance Institution of Finland (SII) identified all persons with a verified diagnosis of AD in Finland on December 31, 2005. For each person with AD a comparison person matched for age, sex and region of residence was also identified. Data on reimbursed drug purchases in 2005 were extracted from the Finnish National Prescription Register (FNPR). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for antidepressant use.Results:The study sample comprised of 28,089 matched pairs of persons with and without AD (mean age 80.0 SD 6.8, 32.2% men).The prevalence of antidepressant use was higher among persons with AD than without AD (29.4% vs. 10.7%, OR = 3.54; 95% CI: 3.38, 3.70). Among the persons with AD, the prevalence of antidepressant use increased with time since AD diagnosis but not with age. Overall, 90.4% of antidepressant users with AD were co-dispensed anti-dementia drugs.Conclusions:The antidepressant use was three times more prevalent among persons with AD compared to those without. Though the antidepressant selection was largely consistent with clinical practice guidelines, the high prevalence of use warrants further investigation given the uncertain effectiveness and adverse events related to these drugs.

Sign in / Sign up

Export Citation Format

Share Document