scholarly journals Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats

2017 ◽  
Vol 42 (11) ◽  
pp. 2128-2140 ◽  
Author(s):  
Michael J Lacagnina ◽  
Ashley M Kopec ◽  
Stewart S Cox ◽  
Richa Hanamsagar ◽  
Corinne Wells ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleus Accumbens ◽  
Early Life ◽  
Life Experience ◽  
Male Rats ◽  
Self Administration ◽  
Early Life Experience ◽  
Anti Inflammatory

scholarly journals Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

2016 ◽  
Vol 41 (12) ◽  
pp. 2851-2861 ◽  
Author(s):  
Candace R Lewis ◽  
Ryan M Bastle ◽  
Tawny B Manning ◽  
Sarah M Himes ◽  
Paulette Fennig ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Rats ◽  
Self Administration

scholarly journals Rearing experience with ramps improves specific learning and behaviour and welfare on a commercial laying farm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kate I. Norman ◽  
Claire A. Weeks ◽  
John F. Tarlton ◽  
Christine J. Nicol
Keyword(s):  
Early Life ◽  
Life Experience ◽  
Later Life ◽  
Welfare Benefits ◽  
Early Life Experience ◽  
Bone Damage ◽  
Specific Learning

AbstractTo access resources in commercial laying houses hens must move between levels with agility to avoid injury. This study considered whether providing ramps during rear improved the ability of birds to transition between levels. Twelve commercial flocks (2000 birds/flock) on a multi-age site were examined between 1 and 40 weeks of age. All birds had access to elevated perching structures from 4 days of age. Six treatment flocks were also provided with ramps during rear to facilitate access to these structures. Flocks were visited three times during rear and three times at lay to record transitioning behaviour and use of the elevated structures, together with scores for keel bone and feather damage. Ramp reared flocks used the elevated structures to a greater extent at rear (P = 0.001) and at lay, when all flocks had ramps, showed less hesitancy [i.e. pacing (P = 0.002), crouching (P = 0.001) and wing-flapping (P = 0.001)] in accessing levels. Mean levels of keel bone damage were reduced in ramp reared flocks (52%) compared with control flocks (64.8%) at 40 weeks of age (P = 0.028). The early life experience of the ramp reared flocks enabled specific learning that translated and persisted in later life and resulted in overall welfare benefits.

scholarly journals Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nucleus Accumbens ◽  
Fixed Ratio ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Self Administration ◽  
Male And Female ◽  
Orexin Receptors ◽  
Male And Female Rats

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.

scholarly journals Early-Life Experience, Epigenetics, and the Developing Brain

2014 ◽  
Vol 40 (1) ◽  
pp. 141-153 ◽  
Author(s):  
Marija Kundakovic ◽  
Frances A Champagne
Keyword(s):  
Early Life ◽  
Life Experience ◽  
Developing Brain ◽  
Early Life Experience

scholarly journals Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience

2015 ◽  
Vol 53 ◽  
pp. 69-81 ◽  
Author(s):  
Benjamin D. Sachs ◽  
Ramona M. Rodriguiz ◽  
Ha L. Tran ◽  
Akshita Iyer ◽  
William C. Wetsel ◽  
...  
Keyword(s):  
Early Life ◽  
Life Experience ◽  
Early Life Experience ◽  
Serotonin Deficiency ◽  
Long Term Consequences
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