scholarly journals A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell

2017 ◽  
Vol 43 (6) ◽  
pp. 1395-1404 ◽  
Author(s):  
Leonardo A Guercio ◽  
Mackenzie E Hofmann ◽  
Sarah E Swinford-Jackson ◽  
Julia S Sigman ◽  
Mathieu E Wimmer ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Anchoring Protein ◽  
Cocaine Reinstatement

scholarly journals Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Kui Chen ◽  
Yu An ◽  
Lu Tie ◽  
Yan Pan ◽  
Xuejun Li
Keyword(s):  
Ampa Receptor ◽  
Drug Target ◽  
Interaction Network ◽  
Subcellular Location ◽  
Dependent Manner ◽  
Potential Drug Target ◽  
Neuroprotective Effects ◽  
Signal Relay ◽  
Anchoring Protein ◽  
Stimulation Of

Now stimulation of AMPA receptor as well as its downstream pathways is considered as potential central mediators in antidepressant mechanisms. As a signal integrator which binds to AMPA receptor, A-kinase anchoring protein 79-(AKAP79-) PKA complex is regarded as a potential drug target to exert neuroprotective effects. A well-tolerated and multitarget drug curcumin has been confirmed to exert antidepressant-like effects. To explore whether AKAP79-PKA complex is involved in curcumin-mediated antiexcitotoxicity, we detected calcium signaling, subcellular location of AKAP79-PKA complex, phosphorylation of glutamate receptor, and ERK and AKT cascades. In this study, we found that curcumin protected neurons from glutamate insult by reducing Ca2+influx and blocking the translocation of AKAP79 from cytomembrane to cytoplasm. In parallel, curcumin enhanced the phosphorylation of AMPA receptor and its downstream pathways in PKA-dependent manner. If we pretreated cells with PKA anchoring inhibitor Ht31 to disassociate PKA from AKAP79, no neuroprotective effects were observed. In conclusion, our results show that AKAP79-anchored PKA facilitated the signal relay from AMPA receptor to AKT and ERK cascades, which may be crucial for curcumin-mediated antiexcitotoxicity.

scholarly journals Prenatal Cocaine Reduces AMPA Receptor Synaptic Expression through Hyperphosphorylation of the Synaptic Anchoring Protein GRIP

2009 ◽  
Vol 29 (19) ◽  
pp. 6308-6319 ◽  
Author(s):  
K. Bakshi ◽  
S. Gennaro ◽  
C. Y. Chan ◽  
M. Kosciuk ◽  
J. Liu ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Prenatal Cocaine ◽  
Anchoring Protein

Biochemical and immunocytochemical characterization of GRIP, a putative AMPA receptor anchoring protein, in rat brain

1998 ◽  
Vol 37 (10-11) ◽  
pp. 1335-1344 ◽  
Author(s):  
Michael Wyszynski ◽  
Eunjoon Kim ◽  
Fu-Chia Yang ◽  
Morgan Sheng
Keyword(s):  
Rat Brain ◽  
Ampa Receptor ◽  
Anchoring Protein

AMPA Receptor Blockade Potentiates the Stimulatory Effect of L-DOPA on Dopamine Release in Dopamine-Deficient Corticostriatal Slice Preparation

2004 ◽  
Vol 16 (1-2) ◽  
pp. 129-139 ◽  
Author(s):  
Zsolt Juranyi ◽  
Nora Sziray ◽  
Bernadett Marko ◽  
Gyorgy Levay ◽  
Laszlo G. Harsing, Jr.
Keyword(s):  
Ampa Receptor ◽  
Dopamine Release ◽  
Receptor Blockade ◽  
Slice Preparation
Sign in / Sign up

Export Citation Format

Share Document