scholarly journals Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice

2017 ◽  
Vol 42 (11) ◽  
pp. 2178-2187 ◽  
Author(s):  
Caleb J Browne ◽  
Xiaodong Ji ◽  
Guy A Higgins ◽  
Paul J Fletcher ◽  
Colin Harvey-Lewis
Keyword(s):  
Locomotor Activity ◽  
Conditioned Reinforcer ◽  
Receptor Activity ◽  
Pharmacological Modulation ◽  
Da Release

scholarly journals Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (5) ◽  
pp. 1692-1700 ◽  
Author(s):  
Christa M. Patterson ◽  
Jenny-Marie T. Wong ◽  
Gina M. Leinninger ◽  
Margaret B. Allison ◽  
Omar S. Mabrouk ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Ventral Tegmental Area ◽  
Extracellular Fluid ◽  
Hypothalamic Area ◽  
Mass Spectrometry Technique ◽  
Spectrometry Technique ◽  
Ventral Tegmental ◽  
Dopamine Efflux ◽  
Physiologic State ◽  
Da Release

Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA) and nucleus accumbens (NAc), to modulate motivation appropriately for physiologic state. Neurotensin (NT)-containing LHA neurons respond to multiple homeostatic challenges and project to the VTA, suggesting that these neurons could link such signals to MLDA function. Indeed, we found that pharmacogenetic activation of LHA NT neurons promoted prolonged DA-dependent locomotor activity and NAc DA efflux, suggesting the importance of VTA neurotransmitter release by LHA NT neurons for the control of MLDA function. Using a microdialysis-mass spectrometry technique that we developed to detect endogenous NT in extracellular fluid in the mouse brain, we found that activation of LHA NT cells acutely increased the extracellular concentration of NT (a known activator of VTA DA cells) in the VTA. In contrast to the prolonged elevation of extracellular NAc DA, however, VTA NT concentrations rapidly returned to baseline. Intra-VTA infusion of NT receptor antagonist abrogated the ability of LHA NT cells to increase extracellular DA in the NAc, demonstrating that VTA NT promotes NAc DA release. Thus, transient LHA-derived NT release in the VTA couples LHA signaling to prolonged changes in DA efflux and MLDA function.

scholarly journals Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

2012 ◽  
Vol 61 (4) ◽  
pp. 581-592 ◽  
Author(s):  
Daniel T. Monaghan ◽  
Mark W. Irvine ◽  
Blaise Mathias Costa ◽  
Guangyu Fang ◽  
David E. Jane
Keyword(s):  
Nmda Receptor ◽  
Receptor Activity ◽  
Allosteric Modulators ◽  
Pharmacological Modulation ◽  
Positive Allosteric Modulators

2064-P: Pharmacological Modulation of Prostaglandin E2 Receptor Activity Enhances ß-Cell Mass and Maintains ß-Cell Identity in a Mouse Model of Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2064-P
Author(s):  
ASHLEY A. CHRISTENSEN ◽  
SPENCER R. ANDREI ◽  
JENNIFER C. DUNN ◽  
VALERIE F. RICCIARDI ◽  
WILLIAM A. PACE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
Prostaglandin E2 ◽  
Cell Mass ◽  
Receptor Activity ◽  
Cell Identity ◽  
Pharmacological Modulation ◽  
Prostaglandin E2 Receptor

196-OR: Pharmacological Modulation of Prostaglandin E2 Receptor Activity Enhances ß-Cell Mass in a Mouse Model of Type 2 Diabetes and Human Islets

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 196-OR
Author(s):  
SPENCER R. ANDREI ◽  
JENNIFER C. DUNN ◽  
ASHLEY A. CHRISTENSEN ◽  
VALERIE F. RICCIARDI ◽  
WILLIAM A. PACE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
Prostaglandin E2 ◽  
Cell Mass ◽  
Human Islets ◽  
Receptor Activity ◽  
Pharmacological Modulation ◽  
Prostaglandin E2 Receptor

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear
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