scholarly journals Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

2016 ◽  
Vol 41 (12) ◽  
pp. 2862-2871 ◽  
Author(s):  
Ana Patrícia Simões ◽  
Nuno J Machado ◽  
Nélio Gonçalves ◽  
Manuella P Kaster ◽  
Ana T Simões ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Memory ◽  
Adenosine A2a Receptors ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex

2018 ◽  
Vol 9 ◽  
Author(s):  
Amber Kerkhofs ◽  
Paula M. Canas ◽  
A. J. Timmerman ◽  
Tim S. Heistek ◽  
Joana I. Real ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fast Spiking ◽  
Adenosine A2a

scholarly journals Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity

2008 ◽  
Vol 15 (4) ◽  
pp. 252-260 ◽  
Author(s):  
C. Kluge ◽  
C. Stoppel ◽  
C. Szinyei ◽  
O. Stork ◽  
H.-C. Pape
Keyword(s):  
Synaptic Plasticity ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Hippocampal Synaptic Plasticity

scholarly journals Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

2015 ◽  
Vol 9 ◽  
Author(s):  
Benjamin Chew ◽  
Jae Ryun Ryu ◽  
Teclise Ng ◽  
Dongliang Ma ◽  
Ananya Dasgupta ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dentate Gyrus ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Gsk 3Β

scholarly journals Sex-Specific Linear Polyubiquitination Is a Critical Regulator of Contextual Fear Memory Formation

2021 ◽  
Vol 15 ◽  
Author(s):  
Madeline Musaus ◽  
Kayla Farrell ◽  
Shaghayegh Navabpour ◽  
W. Keith Ray ◽  
Richard F. Helm ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Memory ◽  
Memory Formation ◽  
Axonal Guidance ◽  
Cell Junction ◽  
Ubiquitin Chain ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Protein Ubiquitination

Strong evidence supports that protein ubiquitination is a critical regulator of fear memory formation. However, as this work has focused on protein degradation, it is currently unknown whether polyubiquitin modifications that are independent of the proteasome are involved in learning-dependent synaptic plasticity. Here, we present the first evidence that atypical linear (M1) polyubiquitination, the only ubiquitin chain that does not occur at a lysine site and is largely independent of the proteasome, is critically involved in contextual fear memory formation in the amygdala in a sex-specific manner. Using immunoblot and unbiased proteomic analyses, we found that male (49) and female (14) rats both had increased levels of linear polyubiquitinated substrates following fear conditioning, though none of these protein targets overlapped between sexes. In males, target protein functions involved cell junction and axonal guidance signaling, while in females the primary target was Adiponectin A, a critical regulator of neuroinflammation, synaptic plasticity, and memory, suggesting sex-dependent functional roles for linear polyubiquitination during fear memory formation. Consistent with these increases, in vivo siRNA-mediated knockdown of Rnf31, an essential component of the linear polyubiquitin E3 complex LUBAC, in the amygdala impaired contextual fear memory in both sexes without affecting memory retrieval. Collectively, these results provide the first evidence that proteasome-independent linear polyubiquitination is a critical regulator of fear memory formation, expanding the potential roles of ubiquitin-signaling in learning-dependent synaptic plasticity. Importantly, our data identify a novel sex difference in the functional role of, but not a requirement for, linear polyubiquitination in fear memory formation.

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