scholarly journals The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects

2016 ◽  
Vol 41 (12) ◽  
pp. 2818-2829 ◽  
Author(s):  
Melanie L Schwandt ◽  
Carlos R Cortes ◽  
Laura E Kwako ◽  
David T George ◽  
Reza Momenan ◽  
...  
Keyword(s):  
Crf1 Antagonist ◽  
Alcohol Dependent

Rumination Predicts Increased Craving for Alcohol-Dependent Adults

2013 ◽  
Author(s):  
A. Gemelli ◽  
S. Querci ◽  
A. M. Lugli ◽  
F. Canfora ◽  
C. Annovi ◽  
...  
Keyword(s):  
Alcohol Dependent

Acamprosate Decreases the Severity and Duration of Relapse and Aids in Postrelapse Recovery of Abstinence in Alcohol-Dependent Patients

2006 ◽  
Author(s):  
Eugene Schneider ◽  
Khalil Saikali ◽  
Daozhi Zhang ◽  
Allyson Gage ◽  
Jeanne Vander Zanden
Keyword(s):  
Alcohol Dependent

TGF-β enhances alcohol dependent hepatocyte damage via downregulation of alcohol dehydrogenase I

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
L Ciuclan ◽  
C Stump ◽  
I Ilkavets ◽  
H Weng ◽  
MV Singer ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Hepatocyte Damage ◽  
Alcohol Dependent

TGF-β enhances alcohol dependent hepatocyte damage via downregulation of alcohol dehydrogenase I

2009 ◽  
Vol 47 (09) ◽  
Author(s):  
LI Ciuclan ◽  
S Ehnert ◽  
I Ilkavets ◽  
H Weng ◽  
H Gaitantzi ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Hepatocyte Damage ◽  
Alcohol Dependent

Structural brain differences in alcohol dependent subjects with and without comorbid affective pathology - a cMRI study

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
D Wedekind ◽  
B Bandelow ◽  
DJ Stein ◽  
U Havemann-Reinecke ◽  
S Bloch ◽  
...  
Keyword(s):  
Structural Brain ◽  
Alcohol Dependent

TGF-β interference with MEOS and ADH metabolising systems may promote alcohol dependent liver damage

2007 ◽  
Vol 45 (01) ◽  
Author(s):  
L Ciuclan ◽  
P Godoy ◽  
S Ehnert ◽  
H Weng ◽  
MV Singer ◽  
...  
Keyword(s):  
Liver Damage ◽  
Alcohol Dependent

Probing the Substrate Promiscuity of Isopentenyl Phosphate Kinase as a Platform for Hemiterpene Analogue Production

2019 ◽  
Author(s):  
Sean Lund ◽  
Taylor Courtney ◽  
Gavin Williams
Keyword(s):  
Synthetic Biology ◽  
Building Blocks ◽  
Isoprenoid Biosynthesis ◽  
Thermoplasma Acidophilum ◽  
Substrate Promiscuity ◽  
Enzymatic Pathways ◽  
First Time ◽  
Rate Limiting ◽  
Alcohol Dependent ◽  
Isopentenyl Phosphate

Isoprenoids are a large class of natural products with wide-ranging applications. Synthetic biology approaches to the manufacture of isoprenoids and their new-to-nature derivatives are limited due to the provision in Nature of just two hemiterpene building blocks for isoprenoid biosynthesis. To address this limitation, artificial chemo-enzymatic pathways such as the alcohol-dependent hemiterpene pathway (ADH) serve to leverage consecutive kinases to convert exogenous alcohols to pyrophosphates that could be coupled to downstream isoprenoid biosynthesis. To be successful, each kinase in this pathway should be permissive of a broad range of substrates. For the first time, we have probed the promiscuity of the second enzyme in the ADH pathway, isopentenyl phosphate kinase from Thermoplasma acidophilum, towards a broad range of acceptor monophosphates. Subsequently, we evaluate the suitability of this enzyme to provide non-natural pyrophosphates and provide a critical first step in characterizing the rate limiting steps in the artificial ADH pathway.<br>

Sign in / Sign up

Export Citation Format

Share Document