scholarly journals Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood

2016 ◽  
Vol 41 (10) ◽  
pp. 2473-2480 ◽  
Author(s):  
Andrew Schwehm ◽  
Delbert G Robinson ◽  
Juan A Gallego ◽  
Katherine H Karlsgodt ◽  
Toshikazu Ikuta ◽  
...  
Keyword(s):  
White Matter ◽  
Middle Adulthood ◽  
White Matter Tracts ◽  
Sex Effects ◽  
Age And Sex

scholarly journals Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study

2021 ◽  
Author(s):  
Katherine E. Lawrence ◽  
Leila Nabulsi ◽  
Vigneshwaran Santhalingam ◽  
Zvart Abaryan ◽  
Julio E. Villalon-Reina ◽  
...  
Keyword(s):  
White Matter ◽  
Shell Model ◽  
Brain Aging ◽  
Diffusion Tensor ◽  
Cross Sectional ◽  
Sex Effects ◽  
White Matter Microstructure ◽  
Weighted Magnetic Resonance Imaging ◽  
Age And Sex ◽  
Single Shell

AbstractA comprehensive characterization of the brain’s white matter is critical for improving our understanding of healthy and diseased aging. Here we used diffusion-weighted magnetic resonance imaging (dMRI) to estimate age and sex effects on white matter microstructure in a cross-sectional sample of 15,628 adults aged 45–80 years old (47.6% male, 52.4% female). Microstructure was assessed using the following four models: a conventional single-shell model, diffusion tensor imaging (DTI); a more advanced single-shell model, the tensor distribution function (TDF); an advanced multi-shell model, neurite orientation dispersion and density imaging (NODDI); and another advanced multi-shell model, mean apparent propagator MRI (MAPMRI). Age was modeled using a data-driven statistical approach, and normative centile curves were created to provide sex-stratified white matter reference charts. Participant age and sex substantially impacted many aspects of white matter microstructure across the brain, with the advanced dMRI models TDF and NODDI detecting such effects the most sensitively. These findings and the normative reference curves provide an important foundation for the study of healthy and diseased brain aging.

Age-depending degeneration of white matter tracts – A DTI-Study

2010 ◽  
Vol 41 (01) ◽  
Author(s):  
J Faber ◽  
JC Schöne-Bake ◽  
C Melzer ◽  
M Tittgemeyer ◽  
B Weber
Keyword(s):  
White Matter ◽  
White Matter Tracts

Individual differences in white and grey matter structure associated with verbal habits of thought

2019 ◽  
Author(s):  
Justin C. Hayes ◽  
Katherine L Alfred ◽  
Rachel Pizzie ◽  
Joshua S. Cetron ◽  
David J. M. Kraemer
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Cognitive Processing ◽  
Grey Matter ◽  
Structural Changes ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Self Report ◽  
White Matter Tracts

Modality specific encoding habits account for a significant portion of individual differences reflected in functional activation during cognitive processing. Yet, little is known about how these habits of thought influence long-term structural changes in the brain. Traditionally, habits of thought have been assessed using self-report questionnaires such as the visualizer-verbalizer questionnaire. Here, rather than relying on subjective reports, we measured habits of thought using a novel behavioral task assessing attentional biases toward picture and word stimuli. Hypothesizing that verbal habits of thought are reflected in the structural integrity of white matter tracts and cortical regions of interest, we used diffusion tensor imaging and volumetric analyses to assess this prediction. Using a whole-brain approach, we show that word bias is associated with increased volume in several bilateral language regions, in both white and grey matter parcels. Additionally, connectivity within white matter tracts within an a priori speech production network increased as a function of word bias. These results demonstrate long-term structural and morphological differences associated with verbal habits of thought.

Age and sex effects on brain morphology

1997 ◽  
Vol 21 (8) ◽  
pp. 1231-1237 ◽  
Author(s):  
Theodore J. Passe ◽  
Pradeep Rajagopalan ◽  
Larry A. Tupler ◽  
Christopher E. Byrum ◽  
James R. Macfall ◽  
...  
Keyword(s):  
Brain Morphology ◽  
Sex Effects ◽  
Age And Sex

Microstructural differences in visual white matter tracts in people with aniridia

Neuroreport ◽  
2018 ◽  
Vol 29 (17) ◽  
pp. 1473-1478 ◽  
Author(s):  
Courtney R. Burton ◽  
David J. Schaeffer ◽  
Anastasia M. Bobilev ◽  
Jordan E. Pierce ◽  
Amanda L. Rodrigue ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Tracts

scholarly journals White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Reza Tadayonnejad ◽  
Fabrizio Pizzagalli ◽  
Stuart B. Murray ◽  
Wolfgang M. Pauli ◽  
Geena Conde ◽  
...  
Keyword(s):  
Decision Making ◽  
Anorexia Nervosa ◽  
White Matter ◽  
Symptom Severity ◽  
Structural Characteristics ◽  
Data Sets ◽  
White Matter Tracts ◽  
Compulsive Behaviors ◽  
Positive Correlations ◽  
Brain Behavior

AbstractAnorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.

scholarly journals Aquaporin-4 protein expression in normal canine brains

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Patricia Álvarez ◽  
Ester Blasco ◽  
Martí Pumarola ◽  
Annette Wessmann
Keyword(s):  
White Matter ◽  
Cancer Progression ◽  
Aquaporin 4 ◽  
Histopathological Study ◽  
White Matter Tracts ◽  
Aqp4 Expression ◽  
Canine Brain ◽  
Potential Marker ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded

Abstract Background Aquaporin-4 (AQP4) is in growing recognition as potential marker for cancer progression, differentiation and therapeutic intervention. No information is available about AQP4 expression in the normal canine brain. The aim of this histopathological study is to confirm the presence of AQP4 by immunohistochemistry technique in a group of non-pathological canine brains and to describe its expression and distribution across the brain. Results Twelve non-pathological canine brains of various ages (ranging from 21 days to 17 years) and breeds were included in the study. Immunohistochemical expression of AQP4 was analyzed using formalin-fixed paraffin-embedded brain tissue sections. The findings were correlated between AQP4 expressing cells and astrocytes using glial fibrillary acidic protein (GFAP). AQP4 expression was more marked in the astrocyte foot processes of subpial, perivascular and periventricular surfaces in all specimens. The majority of the canine brain sections (9/12) presented with an AQP4 predilection for white matter tracts. Interestingly, the two youngest dogs (21 days and 3 months old) were characterized by diffuse AQP4 labelling in both grey and white matter tracts. This result may suggest that brain development and ageing may play a role in the AQP4 distribution throughout the canine brain. Conclusions This is the first study to describe immunohistochemical distribution of AQP4 in normal canine brains. The AQP4 expression and distribution in non-pathological canine brains was comparable to other species. Larger studies are needed to substantiate the influence of breed and ageing on AQP4 expression in the normal canine brain.

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