scholarly journals Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration

2016 ◽  
Vol 42 (5) ◽  
pp. 1093-1102 ◽  
Author(s):  
Robert W Gould ◽  
Paul W Czoty ◽  
Linda J Porrino ◽  
Michael A Nader
2021 ◽  
Vol 14 (5) ◽  
pp. 1416
Author(s):  
Scott J. Moeller ◽  
Roberto Gil ◽  
Topaz Baumvoll ◽  
Kenneth Wengler ◽  
Natalka Fallon ◽  
...  

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1883
Author(s):  
Sneh Koul ◽  
Victoria L. Schaal ◽  
Subhash Chand ◽  
Steven T. Pittenger ◽  
Neetha Nanoth Vellichirammal ◽  
...  

Smoking remains a significant health and economic concern in the United States. Furthermore, the emerging pattern of nicotine intake between sexes further adds a layer of complexity. Nicotine is a potent psychostimulant with a high addiction liability that can significantly alter brain function. However, the neurobiological mechanisms underlying nicotine’s impact on brain function and behavior remain unclear. Elucidation of these mechanisms is of high clinical importance and may lead to improved therapeutics for smoking cessation. To fill in this critical knowledge gap, our current study focused on identifying sex-specific brain-derived extracellular vesicles (BDEV) signatures in male and female rats post nicotine self-administration. Extracellular vesicles (EVs) are comprised of phospholipid nanovesicles such as apoptotic bodies, microvesicles (MVs), and exosomes based on their origin or size. EVs are garnering significant attention as molecules involved in cell–cell communication and thus regulating the pathophysiology of several diseases. Interestingly, females post nicotine self-administration, showed larger BDEV sizes, along with impaired EV biogenesis compared to males. Next, using quantitative mass spectrometry-based proteomics, we identified BDEV signatures, including distinct molecular pathways, impacted between males and females. In summary, this study has identified sex-specific changes in BDEV biogenesis, protein cargo signatures, and molecular pathways associated with long-term nicotine self-administration.


2020 ◽  
Vol 43 ◽  
Author(s):  
Martina G. Vilas ◽  
Lucia Melloni

Abstract To become a unifying theory of brain function, predictive processing (PP) must accommodate its rich representational diversity. Gilead et al. claim such diversity requires a multi-process theory, and thus is out of reach for PP, which postulates a universal canonical computation. We contend this argument and instead propose that PP fails to account for the experiential level of representations.


Author(s):  
Delbert E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
T. Fast ◽  
J. Stevenson ◽  
...  

Space Lab 3 (SL-3) was flown on Shuttle Challenger providing an opportunity to measure the effect of spaceflight on rat testes. Cannon developed the idea that organisms react to unfavorable conditions with highly integrated metabolic activities. Selye summarized the manifestations of physiological response to nonspecific stress and he pointed out that atrophy of the gonads always occurred. Many papers have been published showing the effects of social interaction, crowding, peck order and confinement. Flickinger showed delayed testicular development in subordinate roosters influenced by group numbers, social rank and social status. Christian reported increasing population size in mice resulted in adrenal hypertrophy, inhibition of reproductive maturation and loss of reproductive function in adults. Sex organ weights also declined. Two male dogs were flown on Cosmos 110 for 22 days. Fedorova reported an increase of 30 to 70% atypical spermatozoa consisting of tail curling and/or the absence of a tail.


Author(s):  
C. S. Potter ◽  
C. D. Gregory ◽  
H. D. Morris ◽  
Z.-P. Liang ◽  
P. C. Lauterbur

Over the past few years, several laboratories have demonstrated that changes in local neuronal activity associated with human brain function can be detected by magnetic resonance imaging and spectroscopy. Using these methods, the effects of sensory and motor stimulation have been observed and cognitive studies have begun. These new methods promise to make possible even more rapid and extensive studies of brain organization and responses than those now in use, such as positron emission tomography.Human brain studies are enormously complex. Signal changes on the order of a few percent must be detected against the background of the complex 3D anatomy of the human brain. Today, most functional MR experiments are performed using several 2D slice images acquired at each time step or stimulation condition of the experimental protocol. It is generally believed that true 3D experiments must be performed for many cognitive experiments. To provide adequate resolution, this requires that data must be acquired faster and/or more efficiently to support 3D functional analysis.


1968 ◽  
Vol 11 (3) ◽  
pp. 576-582 ◽  
Author(s):  
John R. Muma ◽  
Ronald L. Laeder ◽  
Clarence E. Webb

Seventy-eight subjects, identified as possessing voice quality aberrations for six months, constituted four experimental groups: breathiness, harshness, hoarseness, and nasality. A control group included 38 subjects. The four experimental groups were compared with the control group according to personality characteristics and peer evaluations. The results of these comparisons indicated that there was no relationship between voice quality aberration and either personality characteristics or peer evaluations.


2005 ◽  
Vol 38 (24) ◽  
pp. 18
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  

2010 ◽  
Vol 41 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Marco Brambilla ◽  
Simona Sacchi ◽  
Federica Castellini ◽  
Paola Riva

Research has shown that perceived group status positively predicts competence stereotypes but does not positively predict warmth stereotypes. The present study identified circumstances in which group status positively predicts both warmth and competence judgments. Students (N = 86) rated one of two groups (psychologists vs. engineers) presented as either being low or high in social status on warmth and competence. Results showed that status positively predicted competence stereotypes for both groups, but warmth stereotypes only for psychologists, for whom warmth traits are perceived to be functional in goal achievement. Moreover, for psychologists perceived warmth mediated the relationship between status and perceived competence. Results are discussed in terms of the contextual malleability of the relationship between perceived status, warmth, and competence.


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