scholarly journals Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

2016 ◽  
Vol 41 (9) ◽  
pp. 2263-2274 ◽  
Author(s):  
Anushree N Karkhanis ◽  
Jamie H Rose ◽  
Jeffrey L Weiner ◽  
Sara R Jones
Keyword(s):  
Social Isolation ◽  
Opioid Receptor ◽  
Early Life ◽  
Kappa Opioid Receptor ◽  
Dopamine System ◽  
Kappa Opioid ◽  
Isolation Stress ◽  
Social Isolation Stress

Social isolation stress increases kappa opioid receptor function on dopamine terminals in the nucleus accumbens of rats

Alcohol ◽  
2017 ◽  
Vol 60 ◽  
pp. 215
Author(s):  
Anushree N. Karkhanis ◽  
Deborah Leussen ◽  
Jeffrey L. Weiner ◽  
Rong Chen ◽  
Sara R. Jones
Keyword(s):  
Nucleus Accumbens ◽  
Social Isolation ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Receptor Function ◽  
Kappa Opioid ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

2020 ◽  
Vol 13 ◽  
pp. 100267 ◽  
Author(s):  
Sarah C. Simmons ◽  
Ryan D. Shepard ◽  
Shawn Gouty ◽  
Ludovic D. Langlois ◽  
William J. Flerlage ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Kappa Opioid Receptor ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Lateral Habenula

scholarly journals Dopaminergic Cellular and Circuit Contributions to Kappa Opioid Receptor Mediated Aversion

2019 ◽  
Author(s):  
Elyssa Margolis ◽  
Anushree Karkhanis
Keyword(s):  
Opioid Receptor ◽  
Experimental Manipulation ◽  
Kappa Opioid Receptor ◽  
Dopamine Neurons ◽  
Dopamine System ◽  
Kappa Opioid ◽  
Selective Blockade ◽  
Aversive Response ◽  
Peptide Agonist ◽  
Anxiety Depression

Neural circuits that enable an organism to protect itself by promoting escape from immediate threat and avoidance of future injury are conceptualized to carry an “aversive” signal. One of the key molecular elements of these circuits is the kappa opioid receptor (KOR) and its endogenous peptide agonist, dynorphin. In many cases, the aversive response to an experimental manipulation can be eliminated by selective blockade of KOR function, indicating its necessity in transmitting this signal. The dopamine system, through its contributions to reinforcement learning, is also involved in processing of aversive stimuli, and KOR control of dopamine in the context of aversive behavioral states has been intensely studied. In this review, we have discussed the multiple ways in which the KORs regulate dopamine dynamics with a central focus on dopamine neurons and projections from the ventral tegmental area. At the neuronal level, KOR agonists inhibit dopamine neurons both in the somatodendritic region as well as at terminal release sites, through various signaling pathways and ion channels, and these effects are specific to different synaptic sites. While the dominant hypotheses are that aversive states are driven by decreases in dopamine and increases in dynorphin, reported exceptions to these patterns indicate these ideas require refinement. This is critical given that KOR is being considered as a target for development of new therapeutics for anxiety, depression, pain, and other psychiatric disorders.

New C(2)-sulfonyl ester-type Salvinorin A ligands to the kappa-opioid receptor

Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
PR Polepally ◽  
A Keasling ◽  
K White ◽  
E Vardy ◽  
BL Roth ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid
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