scholarly journals AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation

2015 ◽  
Vol 41 (7) ◽  
pp. 1849-1864 ◽  
Author(s):  
Ying Han ◽  
Yixiao Luo ◽  
Jia Sun ◽  
Zengbo Ding ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Dorsal Hippocampus ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Ampk Signaling ◽  
Contextual Fear Memory

scholarly journals Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Min Soo Kang ◽  
Jin-Hee Han
Keyword(s):  
Entorhinal Cortex ◽  
Dorsal Hippocampus ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear Conditioning ◽  
Temporal Association ◽  
Medial Entorhinal Cortex ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Short Period

AbstractFormation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, we optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period.

scholarly journals Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation

2021 ◽  
Vol 28 (8) ◽  
pp. 248-253
Author(s):  
Kiley Martin ◽  
Madeline Musaus ◽  
Shaghayegh Navabpour ◽  
Aspen Gustin ◽  
W. Keith Ray ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory

scholarly journals Ontogeny of contextual fear memory formation, specificity, and persistence in mice

2012 ◽  
Vol 19 (12) ◽  
pp. 598-604 ◽  
Author(s):  
K. G. Akers ◽  
M. Arruda-Carvalho ◽  
S. A. Josselyn ◽  
P. W. Frankland
Keyword(s):  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory
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