scholarly journals Differential Involvement of the Agranular vs Granular Insular Cortex in the Acquisition and Performance of Choice Behavior in a Rodent Gambling Task

2015 ◽  
Vol 40 (12) ◽  
pp. 2832-2842 ◽  
Author(s):  
Abhiram Pushparaj ◽  
Aaron S Kim ◽  
Martin Musiol ◽  
Abraham Zangen ◽  
Zafiris J Daskalakis ◽  
...  
2019 ◽  
Vol 10 ◽  
Author(s):  
Ching-Hung Lin ◽  
Chao-Chih Wang ◽  
Jia-Huang Sun ◽  
Chih-Hung Ko ◽  
Yao-Chu Chiu

Author(s):  
Steffen Hagenbucher ◽  
Göran Birgersson ◽  
Sophie Chattington ◽  
Peter Anderson

2010 ◽  
Vol 3 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Judy Casey ◽  
Andrew Pipingas ◽  
Richard Silberstein ◽  
Luke A. Downey ◽  
Patrick J. Johnston

2015 ◽  
Vol 131 (2) ◽  
pp. 19-24
Author(s):  
Mathew H. Gendle ◽  
Alyssa G. Flashburg ◽  
Kristi L. Higgins ◽  
Kristianne M. Oristian

Abstract Very low levels of systemic total cholesterol (TC) may have adverse neurological consequences, and there is a lack of research investigating how TC levels are related to specific aspects of behavior and cognition. This study examined the relationship between low TC levels and performance on the Iowa Gambling Task (IGT), a standardized measure of decision making. Fasting plasma TC levels were measured in 61 healthy female university undergraduates, various demographic and health measures were obtained, and each participant completed the IGT. Individuals with TC < 140 mg/dL performed significantly more poorly on the IGT than those with TC ≥ 140 mg/dL (p  = 0.01). On the IGT, participants with TC levels < 140 mg/dL persisted in preferentially responding to task stimuli with large and immediate monetary gains, despite the fact that these gains were yoked to increasing and unpredictable losses over time. This difference cannot be attributed to dissimilarities in BMI or general health between the groups. These findings indicate that TC levels < 140 mg/dL are associated with significant impairments in decision making and heightened behavioral impulsivity. Negative cognitive and behavioral outcomes with “real-world” relevance may be associated with very low TC levels.


1999 ◽  
Vol 6 (4) ◽  
pp. 347-362 ◽  
Author(s):  
Frank W. Ohl ◽  
Wolfram Wetzel ◽  
Thomas Wagner ◽  
Alexander Rech ◽  
Henning Scheich

This study examines the role of auditory cortex in the Mongolian gerbil in differential conditioning to pure tones and to linearly frequency-modulated (FM) tones by analyzing the effects of bilateral auditory cortex ablation. Learning behavior and performance were studied in a GO/NO-GO task aiming at avoidance of a mild foot shock by crossing a hurdle in a two-way shuttle box. Hurdle crossing as the conditioned response to the reinforced stimulus (CR+), as false alarm in response to the unreinforced stimulus (CR−), intertrial activity, and reaction times were monitored. The analysis revealed no effects of lesion on pure tone discrimination but impairment of FM tone discrimination. In the latter case lesion effects were dependent on timing of lesion relative to FM tone discrimination training. Lesions before training in naive animals led to a reduced CR+ rate and had no effect on CR− rate. Lesions in pretrained animals led to an increased CR− rate without effects on the CR+ rate. The results suggest that auditory cortex plays a more critical role in discrimination of FM tones than in discrimination of pure tones. The different lesion effects on FM tone discrimination before and after training are compatible with both the hypothesis of a purely sensory deficit in FM tone processing and the hypothesis of a differential involvement of auditory cortex in acquisition and retention, respectively.


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