scholarly journals Phasic Mesolimbic Dopamine Signaling Encodes the Facilitation of Incentive Motivation Produced by Repeated Cocaine Exposure

2014 ◽  
Vol 39 (10) ◽  
pp. 2441-2449 ◽  
Author(s):  
Sean B Ostlund ◽  
Kimberly H LeBlanc ◽  
Alisa R Kosheleff ◽  
Kate M Wassum ◽  
Nigel T Maidment
Keyword(s):  
Incentive Motivation ◽  
Cocaine Exposure ◽  
Mesolimbic Dopamine ◽  
Dopamine Signaling

scholarly journals Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats

2010 ◽  
Vol 104 (2) ◽  
pp. 922-931 ◽  
Author(s):  
Nii A. Addy ◽  
David P. Daberkow ◽  
Jeremy N. Ford ◽  
Paul A. Garris ◽  
R. Mark Wightman
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Cocaine Exposure ◽  
Sprague Dawley ◽  
Nucleus Accumbens Core ◽  
Fast Scan Cyclic Voltammetry ◽  
Uptake Inhibition ◽  
Sprague Dawley Rats ◽  
Dopamine Signaling

Repeated cocaine exposure and withdrawal leads to long-term changes, including behavioral and dopamine sensitization to an acute cocaine challenge, that are most pronounced after long withdrawal periods. However, the changes in dopamine neurotransmission after short withdrawal periods are less well defined. To study dopamine neurotransmission after 1-day withdrawal, we used fast-scan cyclic voltammetry (FSCV) to determine whether repeated cocaine alters rapid dopamine release and uptake in the nucleus accumbens (NAc) core and shell. FSCV was performed in urethane anesthetized male Sprague-Dawley rats that had previously received one or seven daily injections of saline or cocaine (15 mg/kg, ip). In response to acute cocaine, subjects showed increased dopamine overflow that resulted from both increased dopamine release and slowed dopamine uptake. One-day cocaine pre-exposure, however, did not alter dopaminergic responses to a subsequent cocaine challenge. In contrast, 7-day cocaine-treated subjects showed a potentiated rapid dopamine response in both the core and shell after an acute cocaine challenge. In addition, kinetic analysis during the cocaine challenge showed a greater increase in apparent Km of 7-day cocaine exposed subjects. Together, the data provide the first in vivo demonstration of rapid dopamine sensitization in the NAc core and shell after a short withdrawal period. In addition, the data clearly delineate cocaine's release and uptake effects and suggest that the observed sensitization results from greater uptake inhibition in cocaine pre-exposed subjects.

scholarly journals Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling

2011 ◽  
Vol 18 (7) ◽  
pp. 475-483 ◽  
Author(s):  
K. M. Wassum ◽  
S. B. Ostlund ◽  
B. W. Balleine ◽  
N. T. Maidment
Keyword(s):  
Incentive Motivation ◽  
Learning Processes ◽  
Incentive Learning ◽  
Dopamine Signaling

scholarly journals Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anne L. Collins ◽  
Venuz Y. Greenfield ◽  
Jeffrey K. Bye ◽  
Kay E. Linker ◽  
Alice S. Wang ◽  
...  
Keyword(s):  
Sequence Learning ◽  
Mesolimbic Dopamine ◽  
Action Sequence ◽  
Dopamine Signaling

scholarly journals Repeated Cocaine Exposure Facilitates the Expression of Incentive Motivation and Induces Habitual Control in Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61355 ◽  
Author(s):  
Kimberly H. LeBlanc ◽  
Nigel T. Maidment ◽  
Sean B. Ostlund
Keyword(s):  
Incentive Motivation ◽  
Cocaine Exposure
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