scholarly journals Genome-Wide Association Study of Copy Number Variations (CNVs) with Opioid Dependence

2014 ◽  
Vol 40 (4) ◽  
pp. 1016-1026 ◽  
Author(s):  
Dawei Li ◽  
Hongyu Zhao ◽  
Henry R Kranzler ◽  
Ming D Li ◽  
Kevin P Jensen ◽  
...  
Keyword(s):  
Association Study ◽  
Copy Number ◽  
Opioid Dependence ◽  
Genome Wide Association Study ◽  
Copy Number Variations ◽  
Genome Wide Association ◽  
Genome Wide

A genome-wide association study of copy number variations with umbilical hernia in swine

2016 ◽  
Vol 47 (3) ◽  
pp. 298-305 ◽  
Author(s):  
Yi Long ◽  
Ying Su ◽  
Huashui Ai ◽  
Zhiyan Zhang ◽  
Bin Yang ◽  
...  
Keyword(s):  
Association Study ◽  
Copy Number ◽  
Umbilical Hernia ◽  
Genome Wide Association Study ◽  
Copy Number Variations ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese

Aging ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 1206-1222 ◽  
Author(s):  
Xin Zhao ◽  
Xiaomin Liu ◽  
Aiping Zhang ◽  
Huashuai Chen ◽  
Qing Huo ◽  
...  
Keyword(s):  
Association Study ◽  
Copy Number ◽  
Genome Wide Association Study ◽  
Copy Number Variations ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility

2016 ◽  
Vol 149 (3) ◽  
pp. 156-164 ◽  
Author(s):  
Yadav Sapkota ◽  
Ashok Narasimhan ◽  
Mahalakshmi Kumaran ◽  
Badan S. Sehrawat ◽  
Sambasivarao Damaraju
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Copy Number ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Frequency Effect ◽  
Potential Candidate ◽  
Disease Etiology ◽  
Genome Wide ◽  
A Genome

Breast cancer (BC) predisposition in populations arises from both genetic and nongenetic risk factors. Structural variations such as copy number variations (CNVs) are heritable determinants for disease susceptibility. The primary objectives of this study are (1) to identify CNVs associated with sporadic BC using a genome-wide association study (GWAS) design; (2) to utilize 2 distinct CNV calling algorithms to identify concordant CNVs as a strategy to reduce false positive associations in the hypothesis-generating GWAS discovery phase, and (3) to identify potential candidate CNVs for follow-up replication studies. We used Affymetrix SNP Array 6.0 data profiled on Caucasian subjects (422 cases/348 controls) to call CNVs using algorithms implemented in Nexus Copy Number and Partek Genomics Suite software. Nexus algorithm identified CNVs associated with BC (731 autosomal CNVs with >5% frequency in the total sample and Q < 0.05). Thirteen CNVs were identified when Partek algorithm-called CNVs were overlapped with Nexus-identified CNVs; these CNVs showed concordances for frequency, effect size, and direction. Coding genes present within BC-associated CNVs were known to play a role in disease etiology and prognosis. Long noncoding RNAs identified within CNVs showed tissue-specific expression, indicating potential functional relevance of the findings. The identified candidate CNVs warrant independent replication.

scholarly journals Genome-Wide Association Study Identified Copy Number Variants Important for Appendicular Lean Mass

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e89776 ◽  
Author(s):  
Shu Ran ◽  
Yong-Jun Liu ◽  
Lei Zhang ◽  
Yufang Pei ◽  
Tie-Lin Yang ◽  
...  
Keyword(s):  
Association Study ◽  
Lean Mass ◽  
Copy Number ◽  
Genome Wide Association Study ◽  
Copy Number Variants ◽  
Genome Wide Association ◽  
Appendicular Lean Mass ◽  
Genome Wide

scholarly journals Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30860 ◽  
Author(s):  
Yu-Fang Pei ◽  
Lei Zhang ◽  
Tie-Lin Yang ◽  
Yingying Han ◽  
Rong Hai ◽  
...  
Keyword(s):  
Association Study ◽  
Alcohol Drinking ◽  
Copy Number ◽  
Genome Wide Association Study ◽  
Copy Number Variants ◽  
Genome Wide Association ◽  
Genome Wide
Sign in / Sign up

Export Citation Format

Share Document