scholarly journals Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

2011 ◽  
Vol 37 (1) ◽  
pp. 303-304 ◽  
Author(s):  
Emily M Jutkiewicz ◽  
Bernard P Roques
Keyword(s):  
Endogenous Opioids ◽  
Complementary Role ◽  
Delta Receptors

scholarly journals PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

2021 ◽  
Vol 22 (10) ◽  
pp. 5112
Author(s):  
Lotte van Beek ◽  
Éilís McClay ◽  
Saleha Patel ◽  
Marianne Schimpl ◽  
Laura Spagnolo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Parp Inhibitors ◽  
Covalent Modification ◽  
Activation Mechanism ◽  
Cancer Therapies ◽  
Damage Repair ◽  
Complementary Role ◽  
Functional Understanding

Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD+ as a substrate. Poly-ADP-ribosylation (PARylation) is central to the important functions of PARP enzymes in the DNA damage response and nucleosome remodelling. Activation of PARP happens through DNA binding via zinc fingers and/or the WGR domain. Modulation of their activity using PARP inhibitors occupying the NAD+ binding site has proven successful in cancer therapies. For decades, studies set out to elucidate their full-length molecular structure and activation mechanism. In the last five years, significant advances have progressed the structural and functional understanding of PARP1-3, such as understanding allosteric activation via inter-domain contacts, how PARP senses damaged DNA in the crowded nucleus, and the complementary role of histone PARylation factor 1 in modulating the active site of PARP. Here, we review these advances together with the versatility of PARP domains involved in DNA binding, the targets and shape of PARylation and the role of PARPs in nucleosome remodelling.

scholarly journals Changing paradigm for treatment of heavily calcified coronary artery disease. A complementary role of rotational atherectomy and intravascular lithotripsy with shockwave balloon: a case report

2020 ◽  
Author(s):  
Shana Tehrani ◽  
Sudhir Rathore ◽  
Vinod Achan
Keyword(s):  
Coronary Artery ◽  
Interventional Cardiology ◽  
Rotational Atherectomy ◽  
Stent Restenosis ◽  
Case Summary ◽  
Stent Expansion ◽  
Complementary Role ◽  
Artery Disease ◽  
Stenotic Lesions

Abstract Background Management of heavily calcified coronary arteries is still a major challenge in interventional cardiology. Inadequate stent expansion in calcific lesions is the single most important predictor of stent thrombosis and in-stent restenosis. Rotational atherectomy (RA) is an important tool to modify the calcium burden but is associated with limitations and requires specific skills. Intravascular lithotripsy (IVL) is a novel technique to treat calcified stenotic lesions and has been proposed as an alternative to RA with promising results. Case summary We report a case of a patient with severely calcified right coronary artery stenosis successfully treated with combination of RA and IVL. Discussion In this case, we demonstrate that the RA and IVL are complementary strategies, not sufficient on their own and not alternative to each other.

A53 COMPLEMENTARY ROLE OF 111IN PENTETREOTIDE, 99MTC-MDP AND 123I-MIBG IN DETECTING CARCINOID BONE METASTASES

2005 ◽  
Vol 26 (3) ◽  
pp. 284
Author(s):  
G. Gnanasegaran ◽  
A. Rossiter ◽  
J.R. Buscombe ◽  
M.E. Caplin ◽  
D. McCool ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Complementary Role

Superficial fibular neuropathy: Complementary role of ultrasound

2013 ◽  
Vol 47 (5) ◽  
pp. 778-778 ◽  
Author(s):  
Jung Im Suk ◽  
Christina M. Sigur ◽  
Francis O. Walker
Keyword(s):  
Complementary Role

The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism

2012 ◽  
Vol 6 (3) ◽  
pp. 1032-1037 ◽  
Author(s):  
Mohammad Reza Khakzad ◽  
Maryam Javanbakht ◽  
Mohammad Reza Shayegan ◽  
Sina Kianoush ◽  
Fatemeh Omid ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Severity Assessment ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Complementary Role
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