scholarly journals Lithium-Induced Gray Matter Volume Increase As a Neural Correlate of Treatment Response in Bipolar Disorder: A Longitudinal Brain Imaging Study

2010 ◽  
Vol 35 (8) ◽  
pp. 1743-1750 ◽  
Author(s):  
In Kyoon Lyoo ◽  
Stephen R Dager ◽  
Jieun E Kim ◽  
Sujung J Yoon ◽  
Seth D Friedman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Brain Imaging ◽  
Treatment Response ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Imaging Study ◽  
Neural Correlate ◽  
Volume Increase ◽  
Matter Volume ◽  
Brain Imaging Study

scholarly journals A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume Reduction

2016 ◽  
Vol 43 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Carl Johan Ekman ◽  
Predrag Petrovic ◽  
Anette G. M. Johansson ◽  
Carl Sellgren ◽  
Martin Ingvar ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
Matter Volume ◽  
History Of

scholarly journals Gray matter volume covariance networks are associated with altered emotional processing in bipolar disorder: a source-based morphometry study

2021 ◽  
Author(s):  
Alessandro Miola ◽  
Nicolò Trevisan ◽  
Arcangelo Merola ◽  
Francesco Folena Comini ◽  
Daniele Olivo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Emotional Processing ◽  
Gray Matter Volume ◽  
Occipital Cortex ◽  
Type I ◽  
Matter Volume ◽  
Visuospatial Processing ◽  
Neural Signature ◽  
Structural Networks

AbstractWidespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of the brain, and their clinical and psychological function have not been investigated yet in BD. 24 patients with BD type-I (BD-I), and 30 with BD type-II (BD-II), and 45 controls underwent MRI scan. Voxel-based morphometry and source-based morphometry (SBM) were performed to extract structural covariation patterns of GMV. SBM components associated with morphometric differences were compared among diagnoses. Executive function and emotional processing correlated with morphometric characteristics. Compared to controls, BD-I showed reduced GMV in the temporo-insular-parieto-occipital cortex and in the culmen. An SBM component spanning the prefrontal-temporal-occipital network exhibited significantly lower GMV in BD-I compared to controls, but not between the other groups. The structural network covariance in BD-I was associated with the number of previous manic episodes and with worse executive performance. Compared to BD-II, BD-I showed a loss of GMV in the temporal-occipital regions, and this was correlated with impaired emotional processing. Altered prefrontal-temporal-occipital network structure could reflect a neural signature associated with visuospatial processing and problem-solving impairments as well as emotional processing and illness severity in BD-I.

P.2.d.024 Lithium and GSK-3β promoter gene variants influence gray matter volume in bipolar disorder

2014 ◽  
Vol 24 ◽  
pp. S427 ◽  
Author(s):  
S. Poletti ◽  
C. Locatelli ◽  
D. Radaelli ◽  
C. Colombo ◽  
F. Benedetti
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Gene Variants ◽  
Matter Volume ◽  
Promoter Gene ◽  
Gsk 3Β

scholarly journals Preservation of Gray Matter Volume in Early Stage of Bipolar Disorder: A Case for Early Intervention

2020 ◽  
pp. 070674372092782 ◽  
Author(s):  
Kamyar Keramatian ◽  
Wayne Su ◽  
Gayatri Saraf ◽  
Trisha Chakrabarty ◽  
Lakshmi N. Yatham
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Early Stage ◽  
Gray Matter Volume ◽  
Volume Changes ◽  
Matter Volume ◽  
History Of ◽  
Bipolar Patients ◽  
Gray Matter Volumes ◽  
Healthy Participants

Objective: It has been proposed that different stages of the bipolar disorder might have distinct neurobiological changes. However, the evidence for this has not been consistent, as the studies in early stages of the illness are limited by small sample sizes. The purpose of this study was to investigate the gray matter volume changes in bipolar patients who recently recovered from their first episode of mania (FEM). Methods: Using a whole-brain voxel-based analysis, we compared the regional gray matter volumes of 61 bipolar patients who have recovered from their FEM in the past 3 months with 43 age- and gender-matched healthy participants. We also performed a series of subgroup analyses to determine the effects of hospitalization during the FEM, history of depressive episodes, and exposure to lithium. Results: No statistically significant difference was found between gray matter volumes of FEM patients and healthy participants, even at a more liberal threshold ( P < 0.001, uncorrected for multiple comparisons). Voxel-based subgroup analyses did not reveal significant gray matter differences except for a trend toward decreased gray matter volume in left lateral occipital cortex ( P < 0.001, uncorrected) in patients with a previous history of depression. Conclusion: This study represents the largest structural neuroimaging investigation of FEM published to date. Early stage of bipolar disorder was not found to be associated with significant gray matter volume changes. Our findings suggest that there might be a window of opportunity for early intervention strategies to prevent or delay neuroprogression in bipolar disorder.

scholarly journals RARE-14. STRUCTURAL BRAIN PLASTICITY OF THE GRAY MATTER IN PATIENTS WITH BASAL GANGLIA GERM CELL TUMORS: A VBM STUDY

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi224-vi224
Author(s):  
Yanong Li
Keyword(s):  
Basal Ganglia ◽  
Germ Cell ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Germ Cell Tumors ◽  
T Test ◽  
Whole Brain ◽  
Volume Increase ◽  
Matter Volume ◽  
Significant Difference

Abstract OBJECTIVE To assess the whole brain structural plasticity in case of unilateral basal ganglia germ cell tumors (BGGCTs). METHODS To detect changes in gray matter volume of the whole brain from structural Magnetic Resonance Imaging (MRI), we used voxel-based morphometry (VBM) in a sample of 41 patients with BGGCTs invading the left basal ganglia (BasalG_L group; n = 22) or the right basal ganglia (BasalG_R group; n = 19) and a sample of 16 patients with GCTs arising in pineal or suprasellar regions, comparing these groups with 16 age-matched normal controls (NCs) by two-sample t test after that. RESULTS To left BGGCTs patients, the regions of whole brain VBM analysis emphasized a large cluster of voxels with gray matter volume increase in left para hippocampal (k = 529 voxels, T=4.18, p< 0.01) and decrease in left thalamus (k = 527 voxels, T=-4.88, p< 0.01). At the same time, the cluster of voxels with gray matter volume increase in right middle cingulate cortex (rMCC) (k = 172 voxels, T=3.96, p< 0.01), and decrease in right inferior frontal gyrus (rIFG), pars opercular (k = 495 voxels, T= -4.29, p< 0.01) in right BGGCTs patients. Furthermore, gray matter volume showed no significant difference between groups of patients with GCTs arising in pineal or suprasellar regions and NCs by two-sample t test. And the results were corrected by family-wise-error correction. CONCLUSIONS The revealed results demonstrate that slow-growing but destructive lesion of the BGGCTs markedly and asymmetrically atrophies the gray matter volume in specific brain regions and shows compensatory plasticity in each side of cerebral hemisphere. Our findings direct focus on the whole cerebral adaptation that perhaps be a physiologic basis for the high level of functional compensation and partially explain the relationships between gray matter remodeling and cognitive disturbances observed in patients with BGGCTs.

Genetic Variation in CACNA1C, a Gene Associated with Bipolar Disorder, Influences Brainstem Rather than Gray Matter Volume in Healthy Individuals

2010 ◽  
Vol 68 (6) ◽  
pp. 586-588 ◽  
Author(s):  
Barbara Franke ◽  
Alejandro Arias Vasquez ◽  
Joris A. Veltman ◽  
Han G. Brunner ◽  
Mark Rijpkema ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Variation ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Healthy Individuals ◽  
Matter Volume

Increased gray matter volume in lithium-treated bipolar disorder patients

2002 ◽  
Vol 329 (2) ◽  
pp. 243-245 ◽  
Author(s):  
Roberto B. Sassi ◽  
Mark Nicoletti ◽  
Paolo Brambilla ◽  
Alan G. Mallinger ◽  
Ellen Frank ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume
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