scholarly journals Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

2008 ◽  
Vol 34 (5) ◽  
pp. 1198-1208 ◽  
Author(s):  
Rajita Sinha ◽  
Helen C Fox ◽  
Kwangik A Hong ◽  
Keri Bergquist ◽  
Zubin Bhagwagar ◽  
...  
Keyword(s):  
Negative Emotion ◽  
Physiological Responses ◽  
Cue Exposure ◽  
Alcohol Craving ◽  
Alcohol Dependent

Changes in alcohol craving and consumption by phase of menstrual cycle in alcohol dependent women

2006 ◽  
Vol 11 (5) ◽  
pp. 323-332 ◽  
Author(s):  
E. E. Epstein ◽  
K. C. Rhines ◽  
S. Cook ◽  
B. Zdep‐Mattocks ◽  
N. K. Jensen ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Alcohol Craving ◽  
Alcohol Dependent

scholarly journals The physiological responses to acute stress in alcohol-dependent patients: A systematic review

2020 ◽  
Vol 41 ◽  
pp. 1-15
Author(s):  
Ke Chen ◽  
Barbara Hollunder ◽  
Maria Garbusow ◽  
Miriam Sebold ◽  
Andreas Heinz
Keyword(s):  
Systematic Review ◽  
Acute Stress ◽  
Physiological Responses ◽  
Alcohol Dependent

scholarly journals Intravenous Ghrelin Administration Increases Alcohol Craving in Alcohol-Dependent Heavy Drinkers: A Preliminary Investigation

2014 ◽  
Vol 76 (9) ◽  
pp. 734-741 ◽  
Author(s):  
Lorenzo Leggio ◽  
William H. Zywiak ◽  
Samuel R. Fricchione ◽  
Steven M. Edwards ◽  
Suzanne M. de la Monte ◽  
...  
Keyword(s):  
Preliminary Investigation ◽  
Alcohol Craving ◽  
Heavy Drinkers ◽  
Alcohol Dependent

scholarly journals Relationship between the serotonin transporter polymorphism and obsessive–compulsive alcohol craving in alcohol-dependent adults: a pilot study

Alcohol ◽  
2010 ◽  
Vol 44 (5) ◽  
pp. 401-406 ◽  
Author(s):  
Rachel D. Thompson ◽  
Jaimee L. Heffner ◽  
Judith A. Strong ◽  
Thomas J. Blom ◽  
Robert M. Anthenelli
Keyword(s):  
Pilot Study ◽  
Serotonin Transporter ◽  
Obsessive Compulsive ◽  
Alcohol Craving ◽  
Serotonin Transporter Polymorphism ◽  
Alcohol Dependent

Heart rate variability predicts alcohol craving in alcohol dependent outpatients: Further evidence for HRV as a psychophysiological marker of self-regulation

2013 ◽  
Vol 132 (1-2) ◽  
pp. 395-398 ◽  
Author(s):  
Daniel S. Quintana ◽  
Adam J. Guastella ◽  
Iain S. McGregor ◽  
Ian B. Hickie ◽  
Andrew H. Kemp
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Self Regulation ◽  
Alcohol Craving ◽  
Alcohol Dependent

scholarly journals A common molecular mechanism for cognitive deficits and craving in alcoholism

2020 ◽  
Author(s):  
Marcus W. Meinhardt ◽  
Simone Pfarr ◽  
Cathrin Rohleder ◽  
Valentina Vengeliene ◽  
Janet Barroso-Flores ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Executive Control ◽  
Molecular Mechanisms ◽  
Intervention Strategy ◽  
Executive Dysfunction ◽  
Causal Link ◽  
Alcohol Craving ◽  
Pathological Mechanism ◽  
Excessive Alcohol ◽  
Alcohol Dependent

Alcohol-dependent patients commonly show impairments in executive functions that facilitate craving and can lead to relapse. The medial prefrontal cortex, a key brain region for executive control, is prone to alcohol-induced neuroadaptations. However, the molecular mechanisms leading to executive dysfunction in alcoholism are poorly understood. Here using a bi-directional neuromodulation approach we demonstrate a causal link for reduced prefrontal mGluR2 function and both impaired executive control and alcohol craving. By neuron-specific prefrontal knockdown of mGluR2 in rats, we generated a phenotype of reduced cognitive flexibility and excessive alcohol-seeking. Conversely, restoring prefrontal mGluR2 levels in alcohol-dependent rats rescued these pathological behaviors. Also targeting mGluR2 pharmacologically reduced relapse behavior. Finally, we developed a FDG-PET biomarker to identify those individuals that respond to mGluR2-based interventions. In conclusion, we identified a common molecular pathological mechanism for both executive dysfunction and alcohol craving, and provide a personalized mGluR2-mechanism-based intervention strategy for medication development of alcoholism.

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