scholarly journals Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112

2008 ◽  
Vol 34 (5) ◽  
pp. 1277-1287 ◽  
Author(s):  
Dara M Cannon ◽  
Jacqueline M Klaver ◽  
Summer A Peck ◽  
Denise Rallis-Voak ◽  
Kristine Erickson ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Receptor Binding ◽  
Emission Tomography ◽  
Major Depressive ◽  
Positron Emission

scholarly journals Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

2013 ◽  
Vol 74 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Jeffrey M. Miller ◽  
Natalie Hesselgrave ◽  
R. Todd Ogden ◽  
Gregory M. Sullivan ◽  
Maria A. Oquendo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Emission Tomography ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Positron Emission

scholarly journals Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kelly Smart ◽  
Ashley Yttredahl ◽  
Maria A. Oquendo ◽  
J. John Mann ◽  
Ansel T. Hillmer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Kappa Opioid Receptor ◽  
Anterior Cingulate ◽  
Emission Tomography ◽  
Kappa Opioid ◽  
Major Depressive ◽  
Positron Emission

AbstractPreclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, VT) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 VT in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r = −0.85, p = 0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.

scholarly journals Positron Emission Tomography Quantification of Serotonin1AReceptor Binding in Suicide Attempters With Major Depressive Disorder

2015 ◽  
Vol 72 (2) ◽  
pp. 169 ◽  
Author(s):  
Gregory M. Sullivan ◽  
Maria A. Oquendo ◽  
Matthew Milak ◽  
Jeffrey M. Miller ◽  
Ainsley Burke ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Emission Tomography ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Positron Emission
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