scholarly journals From rapid In Vitro screening to rapid In Vivo screening in the drug discovery process

2008 ◽  
Vol 34 (1) ◽  
pp. 251-252 ◽  
Author(s):  
F Ivy Carroll ◽  
Richard A Houghten
Keyword(s):  
Drug Discovery ◽  
In Vitro Screening ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
In Vivo Screening

Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development

2019 ◽  
Vol 25 (39) ◽  
pp. 5395-5431 ◽  
Author(s):  
Fahmida Alam ◽  
Md. Asiful Islam ◽  
Mohammad Amjad Kamal ◽  
Siew Hua Gan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Natural Products ◽  
Drug Discovery ◽  
Drug Development ◽  
Discovery Process ◽  
Drug Discovery Process

Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs, and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.

Full-speed mammalian genetics: in vivo target validation in the drug discovery process

2002 ◽  
Vol 20 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Alejandro Abuin ◽  
Kathleen H Holt ◽  
Kenneth A Platt ◽  
Arthur T Sands ◽  
Brian P Zambrowicz
Keyword(s):  
Drug Discovery ◽  
Discovery Process ◽  
Target Validation ◽  
Drug Discovery Process ◽  
Full Speed ◽  
Mammalian Genetics

On the Interactivity of Complex Synthesis and Tumor Pharmacology in the Drug Discovery Process:  Total Synthesis and Comparative in Vivo Evaluations of the 15-Aza Epothilones

2001 ◽  
Vol 66 (12) ◽  
pp. 4369-4378 ◽  
Author(s):  
Shawn J. Stachel ◽  
Chul Bom Lee ◽  
Maria Spassova ◽  
Mark D. Chappell ◽  
William G. Bornmann ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Total Synthesis ◽  
Discovery Process ◽  
Drug Discovery Process
Sign in / Sign up

Export Citation Format

Share Document