A Genetic Linkage Study of Bipolar Disorder and 13 Markers on Chromosome 11 Including the D2 Dopamine Receptor

1993 ◽  
Vol 9 (4) ◽  
pp. 293-301 ◽  
Author(s):  
John R. Kelsoe ◽  
Helgi Kristbjanarson ◽  
Patricia Bergesch ◽  
Paul Shilling ◽  
Sharon Hirsch ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Dopamine Receptor ◽  
Genetic Linkage ◽  
Linkage Study ◽  
Chromosome 11 ◽  
D2 Dopamine Receptor ◽  
Genetic Linkage Study

Genetic linkage study of bipolar disorder and the serotonin transporter

1996 ◽  
Vol 67 (2) ◽  
pp. 215-217 ◽  
Author(s):  
John R. Kelsoe ◽  
Ronald A. Remick ◽  
A. Dessa Sadovnick ◽  
Helgi Kristbjarnarson ◽  
Pamela Flodman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Genetic Linkage ◽  
Linkage Study ◽  
Genetic Linkage Study

A Genetic Linkage Study of the D2 Dopamine Receptor Locus in Heavy Drinking and Alcoholism

1996 ◽  
Vol 169 (2) ◽  
pp. 243-248 ◽  
Author(s):  
C. C. H. Cook ◽  
G. Palsson ◽  
A. Turner ◽  
D. Holmes ◽  
P. Brett ◽  
...  
Keyword(s):  
Genetic Linkage ◽  
Heavy Drinking ◽  
Linkage Study ◽  
Microsatellite Repeat ◽  
Repeat Polymorphism ◽  
D2 Dopamine Receptor ◽  
Genetic Linkage Study ◽  
Identical By Descent ◽  
Length Polymorphisms ◽  
Receptor Locus

BackgroundReports of an association between restriction fragment length polymorphisms (RFLPs) at the dopamine D2 receptor (DRD2) locus and alcoholism have suggested involvement of that locus in the aetiology of alcoholism.MethodSib pair linkage analyses were conducted in families multiply affected by alcoholism, using both the Taql ‘A’ RFLP and a microsatellite repeat polymorphism at the DRD2 locus.ResultsThe ‘Identical By Descent’ analysis provided significant evidence of an effect of the DRD2 locus on the liability to develop heavy drinking (P<0.0016) and Research Diagnostic Criteria alcoholism (P<0.0003) in the first sample of families studied. However, this result was explicable by the segregation of alleles in a single large sibship, and it was not replicated in a second sample of families.ConclusionsThe results do not support linkage between the DRD2 locus and alcoholism in most of the families studied. It remains possible that this locus influences the predisposition to alcoholism in some families.

A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder

1997 ◽  
Vol 43 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Stephan Claes ◽  
Peter Raeymaekers ◽  
Marleen Van den Broeck ◽  
Sabien Diependaele ◽  
An De bruyn ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Linkage ◽  
Linkage Study ◽  
Chromosome 18 ◽  
Genetic Linkage Study

Genetic Linkage Study of Juvenile Polyposis: Preliminary Analysis

1990 ◽  
pp. 431-432
Author(s):  
Gloria M. Petersen ◽  
Jane Brown ◽  
Xiangdong Bu ◽  
Robert S. Sparkes ◽  
Yusuke Nakamura
Keyword(s):  
Preliminary Analysis ◽  
Genetic Linkage ◽  
Linkage Study ◽  
Juvenile Polyposis ◽  
Genetic Linkage Study

Chromosome 17 markers and von Recklinghausen neurofibromatosis: A genetic linkage study in a British population

Genomics ◽  
1987 ◽  
Vol 1 (4) ◽  
pp. 358-360 ◽  
Author(s):  
Meena Upadhyaya ◽  
Mansoor Sarfarazi ◽  
Susan M. Huson ◽  
Karen Stephens ◽  
Wendy Broadhead ◽  
...  
Keyword(s):  
Genetic Linkage ◽  
Linkage Study ◽  
Chromosome 17 ◽  
Genetic Linkage Study ◽  
Von Recklinghausen

scholarly journals A genetic linkage study of a family with Norrie's disease

Eye ◽  
1988 ◽  
Vol 2 (4) ◽  
pp. 443-447 ◽  
Author(s):  
L Esakowitz ◽  
C Clark ◽  
N Haites ◽  
K Kelly ◽  
A W Johnston
Keyword(s):  
Genetic Linkage ◽  
Linkage Study ◽  
Genetic Linkage Study

scholarly journals A genetic linkage study of facioscapulohumeral (Landouzy-Dejerine) disease with 24 polymorphic DNA probes.

1989 ◽  
Vol 26 (8) ◽  
pp. 490-493 ◽  
Author(s):  
M Upadhyaya ◽  
M Sarfarazi ◽  
P W Lunt ◽  
W Broadhead ◽  
P S Harper
Keyword(s):  
Genetic Linkage ◽  
Linkage Study ◽  
Dna Probes ◽  
Genetic Linkage Study
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