scholarly journals Age-related cortical thickness trajectories in first episode psychosis patients presenting with early persistent negative symptoms

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Carolina Makowski ◽  
Michael Bodnar ◽  
Ashok K Malla ◽  
Ridha Joober ◽  
Martin Lepage
Keyword(s):  
Cortical Thickness ◽  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Age Related ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals Linking persistent negative symptoms to amygdala–hippocampus structure in first-episode psychosis

2017 ◽  
Vol 7 (8) ◽  
pp. e1195-e1195 ◽  
Author(s):  
C Makowski ◽  
M Bodnar ◽  
J J Shenker ◽  
A K Malla ◽  
R Joober ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals T123. PERSISTENT NEGATIVE SYMPTOMS IN FIRST EPISODE PSYCHOSIS: PREVALENCE, PREDICTORS AND PROGNOSIS

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S163-S163 ◽  
Author(s):  
Stephen Austin ◽  
Carsten Hjorthøj ◽  
Ole Mors ◽  
Rikke Gry Secher ◽  
Pia Jeppesen ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms

2013 ◽  
Vol 147 (2-3) ◽  
pp. 223-229 ◽  
Author(s):  
Cindy L. Hovington ◽  
Michael Bodnar ◽  
Ridha Joober ◽  
Ashok K. Malla ◽  
Martin Lepage
Keyword(s):  
Verbal Memory ◽  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms

2015 ◽  
Vol 233 (3) ◽  
pp. 402-408 ◽  
Author(s):  
Cindy L. Hovington ◽  
Michael Bodnar ◽  
M. Mallar Chakravarty ◽  
Ridha Joober ◽  
Ashok K. Malla ◽  
...  
Keyword(s):  
White Matter ◽  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
White Matter Abnormalities ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis

2020 ◽  
pp. 1-12
Author(s):  
Miranda Bridgwater ◽  
Peter Bachman ◽  
Brenden Tervo-Clemmens ◽  
Gretchen Haas ◽  
Rebecca Hayes ◽  
...  
Keyword(s):  
Negative Symptom ◽  
Symptom Severity ◽  
Negative Symptoms ◽  
First Episode Psychosis ◽  
Positive Symptom ◽  
First Episode ◽  
Positive Symptoms ◽  
Symptom Expression ◽  
Age Related ◽  
Episode Psychosis

Abstract Background The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression – how age affects clinical presentation in first-episode psychosis – has not been thoroughly investigated. Methods Using generalized additive modeling, which allows for linear and non-linear functional forms of age-related change, we leveraged symptom data from a large sample of antipsychotic-naïve individuals with first-episode psychosis (N = 340, 12–40 years, 1–12 visits), collected at the University of Pittsburgh from 1990 to 2017. We examined relationships between age and severity of perceptual and non-perceptual positive symptoms and negative symptoms. We tested for age-associated effects on change in positive or negative symptom severity following baseline assessment and explored the time-varying relationship between perceptual and non-perceptual positive symptoms across adolescent development. Results Perceptual positive symptom severity significantly decreased with increasing age (F = 7.0, p = 0.0007; q = 0.003) while non-perceptual positive symptom severity increased with age (F = 4.1, p = 0.01, q = 0.02). Anhedonia severity increased with increasing age (F = 6.7, p = 0.00035; q = 0.0003), while flat affect decreased in severity with increased age (F = 9.8, p = 0.002; q = 0.006). Findings remained significant when parental SES, IQ, and illness duration were included as covariates. There were no developmental effects on change in positive or negative symptom severity (all p > 0.25). Beginning at age 18, there was a statistically significant association between severity of non-perceptual and perceptual symptoms. This relationship increased in strength throughout adulthood. Conclusions These findings suggest that as maturation proceeds, perceptual symptoms attenuate while non-perceptual symptoms are enhanced. Findings underscore how pathological brain–behavior relationships vary as a function of development.

scholarly journals Identifying persistent negative symptoms in first episode psychosis

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Cindy L Hovington ◽  
Michael Bodnar ◽  
Ridha Joober ◽  
Ashok K Malla ◽  
Martin Lepage
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals Developmental Influences on Symptom Expression in Antipsychotic-Naïve First-Episode Psychosis

2020 ◽  
Author(s):  
Miranda Bridgwater ◽  
Peter Bachman ◽  
Brenden Tervo-Clemmens ◽  
Gretchen Haas ◽  
Rebecca Hayes ◽  
...  
Keyword(s):  
Negative Symptom ◽  
Symptom Severity ◽  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Positive Symptoms ◽  
Symptom Expression ◽  
Cross Sectional ◽  
Age Related ◽  
Episode Psychosis

AbstractIntroductionThe neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression – how a person’s age affects clinical presentation in first-episode psychosis – has not been thoroughly investigated.MethodUsing generalized additive modeling, which allows for linear and non-linear functional forms of age-related change, we leveraged symptom data from a large sample of antipsychotic-naïve individuals experiencing a first episode of psychosis (N=340, 12-40 years, 1-12 visits), collected at the University of Pittsburgh from 1990-2017. We examined relationships between age and severity of perceptual and non-perceptual positive symptoms and negative symptoms. We also tested for age-associated effects on change in positive or negative symptom severity following baseline assessment, and explored the time-varying relationship between perceptual and non-perceptual positive symptoms across adolescent development.ResultsIn the cross-sectional and longitudinal data, perceptual positive symptoms significantly decreased with increasing age (F=7.0, p=0.0007; q=0.003) while non-perceptual positive symptoms increased with increasing age (F=4.1, p=0.01, q=0.02). These relationships remained significant when SES, IQ, and illness duration were included as covariates. There were no developmental effects on change in positive or negative symptom severity (all p>0.25). Finally, an association between severity of non-perceptual and perceptual symptoms developed with increasing age, with a significant association starting at age 18.ConclusionThese findings suggest that as cognitive maturation proceeds, perceptual symptoms attenuate while non-perceptual symptoms are enhanced, reflecting influences of developmental processes on psychosis expression. Findings underscore how pathological brain-behavior relationships vary as a function of development.

Persistent Negative Symptoms in First-Episode Psychosis

2017 ◽  
Vol 78 (9) ◽  
pp. 1414-1422 ◽  
Author(s):  
Olga Puig ◽  
Immaculada Baeza ◽  
Elena de la Serna ◽  
Bibiana Cabrera ◽  
Gisela Mezquida ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms
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