The impact of helium shortages on basic research

2014 ◽  
Vol 10 (7) ◽  
pp. 467-470 ◽  
Author(s):  
W. P. Halperin
Keyword(s):  
Economies ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 42
Author(s):  
Maria Adamakou ◽  
Dimitris Kallioras ◽  
George Petrakos

Universities are emerging growth determinants. This is so as, in addition to the fulfillment of their traditional role in teaching and (basic) research, universities, as aptly described within the helix framework, are expected to engage in regional development processes. The paper aims to detect trends of convergence among EU universities in terms of performance. To the best of our knowledge, this topic has not hitherto been examined. The empirical analysis of the paper covers the period 2014–2021, utilizes data obtained from URAP (University Ranking by Academic Performance), and employs the methodological approach of convergence clubs. The findings of the paper provide valuable insight into both theory and policy-making. We conclude that despite the unification of EU educational space, trends of divergence among EU universities are still present, and notable divisions still remain. Consequently, this indicates that the impact of EU universities on the formation of spatial disparities across EU space is not neutral.


2009 ◽  
Vol 55 (4) ◽  
pp. 641-658 ◽  
Author(s):  
Karl V Voelkerding ◽  
Shale A Dames ◽  
Jacob D Durtschi

Abstract Background: For the past 30 years, the Sanger method has been the dominant approach and gold standard for DNA sequencing. The commercial launch of the first massively parallel pyrosequencing platform in 2005 ushered in the new era of high-throughput genomic analysis now referred to as next-generation sequencing (NGS). Content: This review describes fundamental principles of commercially available NGS platforms. Although the platforms differ in their engineering configurations and sequencing chemistries, they share a technical paradigm in that sequencing of spatially separated, clonally amplified DNA templates or single DNA molecules is performed in a flow cell in a massively parallel manner. Through iterative cycles of polymerase-mediated nucleotide extensions or, in one approach, through successive oligonucleotide ligations, sequence outputs in the range of hundreds of megabases to gigabases are now obtained routinely. Highlighted in this review are the impact of NGS on basic research, bioinformatics considerations, and translation of this technology into clinical diagnostics. Also presented is a view into future technologies, including real-time single-molecule DNA sequencing and nanopore-based sequencing. Summary: In the relatively short time frame since 2005, NGS has fundamentally altered genomics research and allowed investigators to conduct experiments that were previously not technically feasible or affordable. The various technologies that constitute this new paradigm continue to evolve, and further improvements in technology robustness and process streamlining will pave the path for translation into clinical diagnostics.


2011 ◽  
Vol 437 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Christopher G. R. Perry ◽  
Daniel A. Kane ◽  
Chien-Te Lin ◽  
Rachel Kozy ◽  
Brook L. Cathey ◽  
...  

Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However, estimates of the Km for ADP vary considerably (~20–300 μM) and tend to overestimate respiration at rest. Noting that PmFBs spontaneously contract during respiration experiments, we systematically determined the impact of contraction, temperature and oxygenation on ADP-stimulated respiratory kinetics. BLEB (blebbistatin), a myosin II ATPase inhibitor, blocked contraction under all conditions and yielded high Km values for ADP of >~250 and ~80 μM in red and white rat PmFBs respectively. In the absence of BLEB, PmFBs contracted and the Km for ADP decreased ~2–10-fold in a temperature-dependent manner. PmFBs were sensitive to hyperoxia (increased Km) in the absence of BLEB (contracted) at 30 °C but not 37 °C. In PmFBs from humans, contraction elicited high sensitivity to ADP (Km<100 μM), whereas blocking contraction (+BLEB) and including a phosphocreatine/creatine ratio of 2:1 to mimic the resting energetic state yielded a Km for ADP of ~1560 μM, consistent with estimates of in vivo resting respiratory rates of <1% maximum. These results demonstrate that the sensitivity of muscle to ADP varies over a wide range in relation to contractile state and cellular energy charge, providing evidence that enzymatic coupling of energy transfer within skeletal muscle becomes more efficient in the working state.


Resources ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 116
Author(s):  
Mariusz Jedliński ◽  
Mariusz Sowa

Despite the commonly observed trend towards mechanization and automation of operational processes, the potential benefits of wooden pallets as an essential element of the infrastructure of logistic processes are often overlooked in considerations related to sustainable development. Aspects that are mentioned more often include the very idea of the economy itself (circular economy), characteristics of logistics (green), features of the supply chain itself (sustainable) or expectations towards transport (ecological). The authors believe that the idea of total cost of ownership (TCO) in relation to wooden pallets can be a key component of holistic thinking in terms of sustainable development. In a situation where in relation to logistics, reasonable expectations for developing sustainable supply chains are made, paying attention to such a common logistic facility, namely a cargo pallet, which is given so little attention in research, is, in the opinion of the authors, absolutely justified. Therefore, the article presents an original approach to the problem of aggregation of all costs that cargo pallets generate in their operational life cycle, using the total cost of ownership (TCO) analysis methodology. The main goal of the article, however, is to show that the total cost of ownership of a pallet (not only owning it) can become an effective tool used to significantly reduce the costs of logistic activity of enterprises (as well as whole supply chains) and support the idea of sustainable development in practice. Using the primary data from questionnaire research, the focus was on considerations that were of identification character (cognitive and explanatory considerations), which are typical for basic research that aims to explain given phenomena. Thus, the presented cognitive process covers two main areas, namely: the general theory of sustainable development and the specificity of wooden pallets as carriers used in goods trading in terms of their total costs of ownership.


Author(s):  
L. L. FITUNI

The article is an attempt to predict the main trends of the political, cultural and ideological development of the Middle East in the  medium and long term, taking into account the impact of  international terrorism. To provide optimal solutions possible the  author identifies a number of core components. Basing this selection  he offers his vision of the likely behaviour of key state and non-state  actors as well as the forthcoming fate of the objects of their attention. In preparing the scenarios, the main methods of  predictive analytics were used: statistical analysis, intellectual  analysis of data, analysis of patterns and models conducted within  the framework of the Russian Foundation for Basic Research project  “The Phenomenon of the Islamic State” in the context of the development of a modern Eastern society. “The article is based  on an interpretation of the main conclusions and results of using those methods and methodologies. The article asserts that the recent growth of radical Islam in the East and political populism  in the West are close root causes. Despite all the differences in the  rhetoric and the outward forms, they represent a defensive response  on the part of those segments of Eastern and  Western societies that have failed to adjust to rigid paradigms of  globalization. Intra- and inter-confessional conflicts may become the  prevailing form of military threats in the region, beginning around  the 2020s. Their heralds are already visible in conflicts in Iraq, Syria, Yemen and, to a lesser extent, in Lebanon, Bahrain and on the east  coast of the Arabian Peninsula. Interstate Shiite-Sunni contradictions have so far been limited by political-ideological  confrontation and diplomatic demarches, sometimes accompanied by various embargoes, such as the recent Qatar crisis. Even the physical destruction of the selfproclaimed Islamic pseudo-state in MENA will take some time. Under favorable circumstances, ISIS units may be squeezed out of the important settlements of Syria and Iraq  within a year. This will not mean the end of ISIS. The experience of  the war with terrorist groups in Libya, Algeria, West Africa, Somalia,  Afghanistan, and Southeast Asia shows that even when driven out  into the desert or sparsely populated areas, fragmented but linked  groups of terrorists continue for quite some time to inflict harassing attacks on government forces and objects, to make long  sorties and to arrange spectacular acts of terrorism. Most likely, the  forces interested in maintaining the problems of international terrorism high on the agenda will not sit idly by but will  undertake spectacular and noteworthy actions to keep terrorism  issues in the limelight. As a result, the intensity of terrorist attacks in  the West may increase, since even limited terrorist attacks in  Europe cause more media coverage in the world media than any acts of terrorism in the Middle East. To achieve these goals, new channels and forms of imple mentation of terrorist attacks will  be used, such as terrorist acts involving children, ordinary means of  transport, during the course of mass and symbolic political events, elections, etc.


ESMO Open ◽  
2018 ◽  
Vol 3 (1) ◽  
pp. e000258 ◽  
Author(s):  
Elena Pallari ◽  
Anthony W Fox ◽  
Grant Lewison

BackgroundThis is an appraisal of the impact of cited research evidence underpinning the development of cancer clinical practice guidelines (CPGs) by the professional bodies of the European Society for Medical Oncology (ESMO), the National Institute for Health and Care Excellence (NICE) and the Scottish Intercollegiate Guidelines Network (SIGN).MethodsA total of 101 CPGs were identified from ESMO, NICE and SIGN websites across 13 cancer sites. Their 9486 cited references were downloaded from the Web of Science Clarivate Group database, analysed on Excel (2016) using Visual Basic Application macros and imported onto SPSS (V.24.0) for statistical tests.ResultsESMO CPGs mostly cited research from Western Europe, while the NICE and SIGN ones from the UK, Canada, Australia and Scandinavian countries. The ESMO CPGs cited more recent and basic research (eg, drugs treatment), in comparison with NICE and SIGN CPGs where older and more clinical research (eg, surgery) papers were referenced. This chronological difference in the evidence base is also in line with that ESMO has a shorter gap between the publication of the research and its citation on the CPGs. It was demonstrated that ESMO CPGs report more chemotherapy research, while the NICE and SIGN CPGs report more surgery, with the results being statistically significant.ConclusionsWe showed that ESMO, NICE and SIGN differ in their evidence base of CPGs. Healthcare professionals should be aware of this heterogeneity in effective decision-making of tailored treatments to patients, irrespective of geographic location across Europe.


2021 ◽  
Vol 35 (35) ◽  
pp. 65-80
Author(s):  
Stanisław Zarobny ◽  
Agnieszka Sałek-Imińska

Over the last thirty years, the importance and interest in cultural factors in international relations and in international security has increased. The links between culture and security, and in particular the impact of culture on security, are issues whose importance is growing and which are being increasingly studied. They are regarded as a multifaceted problem, as cultural differences have become the cause of conflicts and wars, and tendencies of cultural domination have led to the destruction of cultures and entire civilizations. It therefore seems interesting to reflect on the process of developing an independent strategic culture of the Russian Federation. The purpose of the article is to discuss the process of shaping the independent strategic culture of the Russian Federation and to address four basic research problems: the sources of Russian strategic culture; the indication which of them are primary and which are secondary ones; determining whether Russian strategic culture underwent evolution; and determining whether then Cold War influenced the shape of today’s strategic culture of the Russian Federation. To achieve the intended purpose of the article, critical analysis of literature is applied, which allowed to find answers to the research questions.


Author(s):  
Michael J. Saks ◽  
Barbara A. Spellman

Rules of evidence are designed to facilitate trials by controlling what evidence may be presented at trial. Those rules came into being, and evolved over time, due to changes in trial process and structure – especially following the rise of adversarial procedure, whereby control over the marshaling and presentation of facts shifted from judges to lawyers. Refinements and reforms continue to be undertaken to try to improve the scope and clarity of the rules. Trial judges must not only apply the rules, they also have the discretion to make rulings in light of their expectations of the impact they think the evidence will have on jurors. This task involves metacognition: one human trying to estimate the thought processes of others. Thus, evidence rulemakers have been and are, effectively, applied psychologists. The rules of evidence reflect their understanding of the psychological processes affecting, and capabilities and limitations of witnesses, lawyers and jurors. Psychological research and methods provide an additional source of insight and assistance in that endeavor. Better psychological understanding should lead to more effective rules. Psychologists typically employ the scientific method: empirically testing hypotheses in an effort to discover which are valid understandings of how people perceive, store, and retrieve information. To evaluate evidence rules, one could conduct experiments directly on a rule, or borrow from existing knowledge developed in basic research and see whether those understandings support existing or proposed evidence rules.


Author(s):  
Ulf Ziemann

This chapter reviews effects of central nervous system (CNS) active drugs specifically on activity-dependent plasticity and learning. The rationale for choosing this focus is the existing evidence that CNS active drugs have an impact on rehabilitation success after stroke to a relevant extent only if coupled with task-specific practice. This chapter reviews pharmacological modulation of stimulation-induced long-term potentiation (LTP) in animal and human studies because synaptic plasticity in the form of LTP is a basic mechanism of learning and memory processes. Next, the chapter reviews the evidence of CNS active drugs on learning in animal and human studies. In the third part, the impact of CNS active drugs on neurorehabilitation of stroke patients is surveyed and the translational cascade from basic research to clinical studies is described. Finally, limitations of the current studies, open questions, and future directions are discussed. This chapter demonstrates significant impact of neuropharmacology on activity-dependent plasticity and learning.


RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001063 ◽  
Author(s):  
Berend Stoel

After decades of basic research with many setbacks, artificial intelligence (AI) has recently obtained significant breakthroughs, enabling computer programs to outperform human interpretation of medical images in very specific areas. After this shock wave that probably exceeds the impact of the first AI victory of defeating the world chess champion in 1997, some reflection may be appropriate on the consequences for clinical imaging in rheumatology. In this narrative review, a short explanation is given about the various AI techniques, including ‘deep learning’, and how these have been applied to rheumatological imaging, focussing on rheumatoid arthritis and systemic sclerosis as examples. By discussing the principle limitations of AI and deep learning, this review aims to give insight into possible future perspectives of AI applications in rheumatology.


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