Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells

2007 ◽  
Vol 10 (5) ◽  
pp. 546-548 ◽  
Author(s):  
Andrei D Sdrulla ◽  
David J Linden
Keyword(s):  
Purkinje Cells ◽  
Dendritic Spine ◽  
Long Term Depression ◽  
Spine Morphology ◽  
Double Dissociation ◽  
Dendritic Spine Morphology ◽  
Cerebellar Purkinje Cells

scholarly journals Impact of JNK and Its Substrates on Dendritic Spine Morphology

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 440 ◽  
Author(s):  
Emilia Komulainen ◽  
Artemis Varidaki ◽  
Natalia Kulesskaya ◽  
Hasan Mohammad ◽  
Christel Sourander ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Lucifer Yellow ◽  
Dendrite Morphology ◽  
Spine Morphology ◽  
Kinase Substrate ◽  
Basal Dendrites ◽  
Dendritic Spine Morphology ◽  
Mushroom Spines

The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins. JNK1 also phosphorylates dendritic spine proteins, and Jnk1-/- mice display a long-term depression deficit. Whether JNK1 or other JNKs regulate spine morphology is thus of interest. Here, we characterize dendritic spine morphology in hippocampus of mice lacking Jnk1-/- using Lucifer yellow labelling. We find that mushroom spines decrease and thin spines increase in apical dendrites of CA3 pyramidal neurons with no spine changes in basal dendrites or in CA1. Consistent with this spine deficit, Jnk1-/- mice display impaired acquisition learning in the Morris water maze. In hippocampal cultures, we show that cytosolic but not nuclear JNK, regulates spine morphology and expression of phosphomimicry variants of JNK substrates doublecortin (DCX) or myristoylated alanine-rich C kinase substrate-like protein-1 (MARCKSL1), rescue mushroom, thin, and stubby spines differentially. These data suggest that physiologically active JNK controls the equilibrium between mushroom, thin, and stubby spines via phosphorylation of distinct substrates.

scholarly journals Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells

2005 ◽  
Vol 89 (6) ◽  
pp. 3790-3806 ◽  
Author(s):  
Nicholas Hernjak ◽  
Boris M. Slepchenko ◽  
Kathleen Fernald ◽  
Charles C. Fink ◽  
Dale Fortin ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Purkinje Cells ◽  
Long Term Depression ◽  
Modeling And Analysis ◽  
Signaling Events ◽  
Cerebellar Purkinje Cells

Phosphorylation of the δ2 glutamate receptor is not required for induction of long-term depression in cerebellar Purkinje cells

2007 ◽  
Vol 58 ◽  
pp. S134
Author(s):  
Ryoichi Nakagami ◽  
Kazuhisa Kohda ◽  
Wataru Kakegawa ◽  
Tetsuro Kondo ◽  
Michisuke Yuzaki
Keyword(s):  
Purkinje Cells ◽  
Glutamate Receptor ◽  
Long Term Depression ◽  
Cerebellar Purkinje Cells

scholarly journals Phospholipase Cβ4 and Protein Kinase Cα and/or Protein Kinase CβI Are Involved in the Induction of Long Term Depression in Cerebellar Purkinje Cells

2001 ◽  
Vol 276 (48) ◽  
pp. 45236-45242 ◽  
Author(s):  
Moritoshi Hirono ◽  
Takashi Sugiyama ◽  
Yasushi Kishimoto ◽  
Ikuko Sakai ◽  
Takahito Miyazawa ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Purkinje Cells ◽  
Long Term Depression ◽  
Protein Kinase Cα ◽  
Cerebellar Purkinje Cells

A1 adenosine receptor as a regulator of the long-term depression of the glutamate-responsiveness of cerebellar Purkinje cells

2009 ◽  
Vol 65 ◽  
pp. S42
Author(s):  
Yosuke Fujita ◽  
Takeshi Shimomura ◽  
Yuji Kamikubo ◽  
Toshihide Tabata ◽  
Kenkichi Fukurotani ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Adenosine Receptor ◽  
Long Term Depression ◽  
A1 Adenosine Receptor ◽  
Cerebellar Purkinje Cells
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