Potential role for adult neurogenesis in the encoding of time in new memories

2006 ◽  
Vol 9 (6) ◽  
pp. 723-727 ◽  
Author(s):  
James B Aimone ◽  
Janet Wiles ◽  
Fred H Gage
Keyword(s):  
Adult Neurogenesis ◽  
Potential Role

scholarly journals Potential role of radial glia in adult neurogenesis of teleost fish

Glia ◽  
2003 ◽  
Vol 43 (1) ◽  
pp. 77-86 ◽  
Author(s):  
G�nther K.H. Zupanc ◽  
Sorcha C. Clint
Keyword(s):  
Adult Neurogenesis ◽  
Teleost Fish ◽  
Potential Role ◽  
Radial Glia

scholarly journals A Runner’s High for New Neurons? Potential Role for Endorphins in Exercise Effects on Adult Neurogenesis

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1077
Author(s):  
Timothy J. Schoenfeld ◽  
Chance Swanson
Keyword(s):  
Adult Neurogenesis ◽  
Potential Role ◽  
Peptide Hormone ◽  
Hippocampal Neurogenesis ◽  
Behavioral Effects ◽  
Direct Effects ◽  
Brain Health ◽  
Endogenous Opioid ◽  
Beta Endorphin ◽  
Beta Endorphins

Physical exercise has wide-ranging benefits to cognitive functioning and mental state, effects very closely resembling enhancements to hippocampal functioning. Hippocampal neurogenesis has been implicated in many of these mental benefits of exercise. However, precise mechanisms behind these effects are not well known. Released peripherally during exercise, beta-endorphins are an intriguing candidate for moderating increases in neurogenesis and the related behavioral benefits of exercise. Although historically ignored due to their peripheral release and status as a peptide hormone, this review highlights reasons for further exploring beta-endorphin as a key mediator of hippocampal neurogenesis. This includes possible routes for beta-endorphin signaling into the hippocampus during exercise, direct effects of beta-endorphin on cell proliferation and neurogenesis, and behavioral effects of manipulating endogenous opioid signaling. Together, beta-endorphin appears to be a promising mechanism for understanding the specific ways that exercise promotes adult neurogenesis specifically and brain health broadly.

New regulators in adult neurogenesis and their potential role for repair

2006 ◽  
Vol 12 (9) ◽  
pp. 400-405 ◽  
Author(s):  
Ravi Jagasia ◽  
Hongjun Song ◽  
Fred H. Gage ◽  
D. Chichung Lie
Keyword(s):  
Adult Neurogenesis ◽  
Potential Role

scholarly journals Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory

2016 ◽  
Vol 1644 ◽  
pp. 127-140 ◽  
Author(s):  
Claudia Lieberwirth ◽  
Yongliang Pan ◽  
Yan Liu ◽  
Zhibin Zhang ◽  
Zuoxin Wang
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Neurogenesis ◽  
Potential Role ◽  
Spatial Learning And Memory

scholarly journals The Entorhinal Cortex and Adult Neurogenesis in Major Depression

2021 ◽  
Vol 22 (21) ◽  
pp. 11725
Author(s):  
Il Bin Kim ◽  
Seon-Cheol Park
Keyword(s):  
Entorhinal Cortex ◽  
Adult Neurogenesis ◽  
Potential Role ◽  
Neural Circuitry ◽  
Hippocampal Neurogenesis ◽  
Dependent Manner ◽  
Hippocampal Function ◽  
Comprehensive Understanding ◽  
Activity Dependent

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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