High cholesterol level is essential for myelin membrane growth

2005 ◽  
Vol 8 (4) ◽  
pp. 468-475 ◽  
Author(s):  
Gesine Saher ◽  
Britta Brügger ◽  
Corinna Lappe-Siefke ◽  
Wiebke Möbius ◽  
Ryu-ichi Tozawa ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
High Cholesterol ◽  
Myelin Membrane ◽  
High Cholesterol Level ◽  
Membrane Growth

EVALUATION OF RISK FACTOR CHRONIC OCCLUSIVE ARTERIAL DISEASE OF LOWER EXTREMITY

2012 ◽  
pp. 16-21
Author(s):  
Quang Thuu Le
Keyword(s):  
Risk Factor ◽  
Lower Extremity ◽  
Cholesterol Level ◽  
Cardiovascular Surgery ◽  
Arterial Disease ◽  
High Cholesterol ◽  
Severe Condition ◽  
Occlusive Arterial Disease ◽  
High Cholesterol Level ◽  
Centre Hospital

Objectives: We research risk factors of chronic occlusive arterial disease of lower extremity. Subjects and methods: From 05/2010 to 04/2012, prospective study at Department of Thoracic and Cardiovascular Surgery of Hue Centre hospital, we have performed 49 patients in 30 males and 19 females from 33 to 92 ages, who were treated chronic occlusive arterial disease of lower extremity. Results: Majority of patients came to hospital with severe condition in grade III and IV according to Leriche-Fontain standards (27.12% and 66.1%). All patients incomed, expect the unmodifiable risk factor (as age, sex), we found socialty risk factor remarable (as hypertension 51.1%, smoking 18.36%, diabetes 10.2%, high cholesterol level 4.08%. Conclusions: Expect the unmodifiable risk factor, we found a the most striking association with hypertension, smoking, diabetes, high cholesterol level.

scholarly journals Is depression a cause of metabolic abnormality? A European Small State experience

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Cuschieri
Keyword(s):  
Metabolic Syndrome ◽  
Cholesterol Level ◽  
Fasting Blood Glucose ◽  
Depression Symptoms ◽  
Health Examination ◽  
High Cholesterol ◽  
Small State ◽  
The Metabolic Syndrome ◽  
High Cholesterol Level ◽  
Increased Risk

Abstract Background A relationship between depression and metabolic syndrome has been reported. Considering the diabesity rates effecting the small state of Malta it was considered appropriate to explore for links between these diseases, their metabolic determinants with depression. Methods A national health examination survey was conducted. A validated questionnaire note down (1) self-reported depression (2) anti-depressive medication (3) PHQ-9 depression symptoms score (>5 positive for depression). Participants with the presence of one or more of these variables were labelled as having depression. Body mass index (BMI), waist circumference (WC) and blood pressure (BP) were measured. Blood testing for fasting blood glucose (FBG) and lipid profile were performed. The biochemical (FBG, Lipid profiles) and anthropometric profiles (BMI, WC, BP) of the depression population were compared to those without this disease. Univariant and multivariant binary logistic regression models were performed. Results The depression population (17.2% of the total population) had significantly higher median LDL, triglyceride (TG) and total cholesterol (TC) levels when compared to those without the disease (p = <0.01). On univariant modelling each variable (LDL OR:1.15 p = 0.01; TG OR:1.16 p = 0.01; TC OR:1.64 p = <0.01) showed a positive association with having depression even after adjusting for confounding factors (sex, age, education, smoking, alcohol habits). On multivariant modelling only an increase in TC was associated with increased risk of having depression (OR: 1.36 CI95%: 1.05-1.76 p = 0.02) after adjusting for confounders. Conclusions The various components of the metabolic syndrome appeared not to be associated with a diagnosis of depression. Only high cholesterol level exhibited a metabolic link with depression. Although further research is merited, it is suggested that physicians incorporate a depression screening tool as part of their consultation when examining high-risk patients. Key messages A metabolic syndrome profile is not linked with depression. A high cholesterol level is linked with depression, making these individuals susceptible to potential cardiovascular disease.

Television Viewing and Pediatric Hypercholesterolemia

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Nathan D. Wong ◽  
Thomas K. Hei ◽  
Paul Y. Qaqundah ◽  
Dennis M. Davidson ◽  
Stanley L. Bassin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Family History ◽  
Cholesterol Level ◽  
Television Viewing ◽  
Positive Family History ◽  
High Cholesterol ◽  
Predictive Values ◽  
Cholesterol Screening ◽  
High Cholesterol Level ◽  
History Of

Cholesterol screening for children is recommended currently only for those with a family history of premature coronary heart disease or hyperlipidemia. The authors report on a pediatric-office-based cholesterol screening program where the predictive values of family history indicators were evaluated along with reported television viewing, physical activity, and dietary habits in 1081 children (aged 2 to 20 years, mean 7.4 ± 3.6 [SD] years). Eight percent of these children had a total cholesterol value of 200 mg/dL or higher; 53% of such children reported watching 2 or more hours of television daily compared with 34% of children with lower cholesterol levels. Multivariate analyses revealed that excessive television viewing was the strongest predictor for a child to have a cholesterol value of 200 mg/dL or higher, with relative risks of 2.2 for 2 to 4 hours of television viewing per day (P < .01) and 4.8 for children watching more than 4 hours/day, when compared to those watching less than 2 hours/day (P < .01). In contrast, a positive family history of a high cholesterol level was only modestly associated with an increased probability of having a high cholesterol level (relative risk 1.6, P < .05), and a history of premature myocardial infarction in a parent or grandparent was not associated with a child's cholesterol level. Excessive television viewing was found to be associated with certain dietary and physical activity habits and may prove to be a useful, global marker for several life-style factors predisposing children to hypercholesterolemia.

scholarly journals Consumer Evaluation of the Role of Functional Food Products in Disease Prevention and the Characteristics of Target Groups

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 69 ◽  
Author(s):  
Brigitta Plasek ◽  
Zoltán Lakner ◽  
Gyula Kasza ◽  
Ágoston Temesi
Keyword(s):  
Immune System ◽  
Cholesterol Level ◽  
Functional Food ◽  
Functional Foods ◽  
Tertiary Education ◽  
Age Groups ◽  
Binary Logistic Regression ◽  
Food Products ◽  
High Cholesterol ◽  
High Cholesterol Level

Our research explores the methods consumers would consider using in order to prevent non-communicable diseases, with consuming functional food products being one of these methods. Previous research has pointed out the importance of missing information such as which diseases worry consumers and what they would use to avoid them. We conducted a personal survey with 1027 people in Hungary about 13 diseases and four prevention methods. We analyzed the results with descriptive statistical methods, binary logistic regression, and random forest. According to our results, the highest proportion of worried respondents think it is justified to consume functional foods for the prevention of digestive problems, a weakened immune system, and high cholesterol level. Our results help to characterize the target group for these three diseases. Completed education plays a key role in choosing functional foods to prevent a weakened immune system. Those with tertiary education are the most likely to choose this prevention method. With the other two diseases, age played a crucial role. All age groups over 36 would be more likely to choose functional foods to prevent digestive problems, whereas in case of high cholesterol level, the 36–50 age group would be more likely to apply this method.

INTRAUTERINE GROWTH RETARDATION AND HIGH CHOLESTEROL LEVEL IN NEWBORNS

2008 ◽  
Vol 9 (1) ◽  
pp. 93
Author(s):  
P. Szitanyi ◽  
M. Dokoupilova ◽  
I. Spalova ◽  
M. Cerny ◽  
J. Janda ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
High Cholesterol ◽  
Intrauterine Growth ◽  
High Cholesterol Level

High Cholesterol Level As A Marker of Allergic Rhinitis Severity

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Dina S Sheha ◽  
Lobna A El-Korashi ◽  
Marwa M El-Begermy ◽  
Amira R Elmahdi
Keyword(s):  
Allergic Rhinitis ◽  
Cholesterol Level ◽  
Blood Lipid ◽  
Cross Sectional Study ◽  
Blood Cholesterol ◽  
Sectional Study ◽  
High Cholesterol ◽  
Blood Lipid Profile ◽  
Cross Sectional ◽  
High Cholesterol Level

Abstract Background There is some evidences illustrated the relation between abnormal blood lipid profile and atopy. But, the evidence about relation between allergic rhinitis (AR) and cholesterol level is conflicting. We aimed to assess correlation between Cholesterol level and severity of AR. Methods 50 AR patients were recruited in this cross-sectional study. Blood samples for blood cholesterol level were drawn from all patients. Results There was a statistically significant positive correlation between TC and visual analogue scale (VAS) score. Conclusion High cholesterol level in AR patients can be a marker of disease severity.

Long Term Effects of Ketogenic Diet in Obese Subjects with High Cholesterol Level

2006 ◽  
Vol 286 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Hussein M. Dashti ◽  
Naji S. Al-Zaid ◽  
Thazhumpal C. Mathew ◽  
Mahdi Al-Mousawi ◽  
Hussain Talib ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Ketogenic Diet ◽  
Long Term Effects ◽  
High Cholesterol ◽  
High Cholesterol Level ◽  
Obese Subjects

scholarly journals The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 935
Author(s):  
Urszula Orzeł ◽  
Jakub Jakowiecki ◽  
Krzysztof Młynarczyk ◽  
Sławomir Filipek
Keyword(s):  
Binding Site ◽  
Cholesterol Level ◽  
Neurodegenerative Disorder ◽  
Amyloid Β ◽  
Cholesterol Concentration ◽  
High Cholesterol ◽  
Binding Motifs ◽  
High Cholesterol Level ◽  
Dynamics Simulations ◽  
Cholesterol Binding

Alzheimer’s disease is the most common progressive neurodegenerative disorder and is characterized by the presence of amyloid β (Aβ) plaques in the brain. The γ-secretase complex, which produces Aβ, is an intramembrane-cleaving protease consisting of four membrane proteins. In this paper we investigated the amyloidogenic fragments of amyloid precursor protein (substrates Aβ43 and Aβ45, leading to less amyloidogenic Aβ40 and more amyloidogenic Aβ42, respectively) docked to the binding site of presenilin, the catalytic subunit of γ-secretase. In total, we performed 9 μs of all-atom molecular dynamics simulations of the whole γ-secretase complex with both substrates in low (10%) and high (50%) concentrations of cholesterol in the membrane. We found that, at the high cholesterol level, the Aβ45 helix was statistically more flexible in the binding site of presenilin than Aβ43. An increase in the cholesterol concentration was also correlated with a higher flexibility of the Aβ45 helix, which suggests incompatibility between Aβ45 and the binding site of presenilin potentiated by a high cholesterol level. However, at the C-terminal part of Aβ45, the active site of presenilin was more compact in the case of a high cholesterol level, which could promote processing of this substrate. We also performed detailed mapping of the cholesterol binding sites at low and high cholesterol concentrations, which were independent of the typical cholesterol binding motifs.

Sign in / Sign up

Export Citation Format

Share Document