scholarly journals Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis

2005 ◽  
Vol 8 (4) ◽  
pp. 413-414 ◽  
Author(s):  
Eric C Dumont ◽  
Gregory P Mark ◽  
Sarah Mader ◽  
John T Williams
Keyword(s):  
Synaptic Transmission ◽  
Excitatory Synaptic Transmission ◽  
Stria Terminalis ◽  
Self Administration ◽  
Bed Nucleus

scholarly journals A Switch in the Neuromodulatory Effects of Dopamine in the Oval Bed Nucleus of the Stria Terminalis Associated with Cocaine Self-Administration in Rats

2011 ◽  
Vol 31 (24) ◽  
pp. 8928-8935 ◽  
Author(s):  
M. Krawczyk ◽  
R. Sharma ◽  
X. Mason ◽  
J. DeBacker ◽  
A. A. Jones ◽  
...  
Keyword(s):  
Stria Terminalis ◽  
Self Administration ◽  
Bed Nucleus

scholarly journals Orexin A role in mechanisms of reinforcement in the bed nucleus of stria terminalis

2015 ◽  
Vol 13 (2) ◽  
pp. 20-26
Author(s):  
Andrei Andreevich Lebedev ◽  
Eugeny Grigorievich Shumilov ◽  
Eugeny Rudolfovich Bychkov ◽  
Vitaly Ivanovich Morozov ◽  
Petr Dmitriyevich Shabanov
Keyword(s):  
Lateral Hypothalamus ◽  
Behavioral Sensitization ◽  
Brain Regions ◽  
Brain Stimulation Reward ◽  
Stria Terminalis ◽  
Self Administration ◽  
Orexin A ◽  
Drug Reinforcement ◽  
Bed Nucleus ◽  
Self Stimulation

The orexin family of hypothalamic neuropeptides has been implicated in reinforcement mechanisms relevant to both food and drug reward. Previous behavioral studies with antagonists at the orexin A-selective receptor OX(1), have demonstrated its involvement in behavioral sensitization, conditioned place-preference, self-administration and reinstatement of drugs abuse. There are dense concentrations of hypocretin receptors, in brain regions implicated in drug reinforcement processes, such as the nucleus accumbens, ventral tegmental area and bed nucleus of the stria terminalis Adult male Wistar rats were implanted the stimulating electrodes to the lateral hypothalamus. Simultaneously, the microcanules were implanted into the BNST to inject the OX(1) receptor antagonist. Rats were trained to perform intracranial self-stimulation. The effects of the OX(1)-selective antagonist SB-408124 on brain stimulation-reward (BSR) were measured. SB-408124 injected into the BNST (1µg/1 µl in volume for each injection.) alone had no effect on self-stimulation of lateral hypothalamus. Amphetamine (1 mg/kg i.p.) potentiated BSR, measured as lowering of BSR threshold and enhancing of BSR frequency. Amphetamine-induced stimulatory effects on intracranial self-stimulation was blocked by injections of SB-408124 into BNST. These data demonstrate that OX(1) play an important role in regulating the reinforcing and reward-enhancing properties of amphetamine and suggest that orexin transmission is likely essential for establishing and maintaining the amphetamine habit in human addicts. However, the observations that OX1 antagonism reduce brain reward and block stress- and cue-induced reinstatement of drug-seeking suggests that this class of compounds may be useful additions to stress-reduction and other behavioral therapies in the treatment of substance abuse disorders.

scholarly journals Sucrose self-administration and CNS activation in the rat

2011 ◽  
Vol 300 (4) ◽  
pp. R876-R884 ◽  
Author(s):  
Dianne P. Figlewicz ◽  
Jennifer L. Bennett-Jay ◽  
Sepideh Kittleson ◽  
Alfred J. Sipols ◽  
Aryana Zavosh
Keyword(s):  
Energy Homeostasis ◽  
Food Reward ◽  
Fixed Ratio ◽  
Progressive Ratio ◽  
Stria Terminalis ◽  
Self Administration ◽  
Bed Nucleus ◽  
Medial Hypothalamus ◽  
Fos Expression

We have previously reported that administration of insulin into the arcuate nucleus of the hypothalamus decreases motivation for sucrose, assessed by a self-administration task, in rats. Because the pattern of central nervous system (CNS) activation in association with sucrose self-administration has not been evaluated, in the present study, we measured expression of c-Fos as an index of neuronal activation. We trained rats to bar-press for sucrose, according to a fixed-ratio (FR) or progressive-ratio (PR) schedule and mapped expression of c-Fos immunoreactivity in the CNS, compared with c-Fos expression in handled controls. We observed a unique expression of c-Fos in the medial hypothalamus (the arcuate, paraventricular, retrochiasmatic, dorsomedial, and ventromedial nuclei) in association with the onset of PR performance, and expression of c-Fos in the lateral hypothalamus and the bed nucleus of stria terminalis in association with the onset of FR performance. c-Fos expression was increased in the nucleus accumbens of both FR and PR rats. Our study emphasizes the importance of both hypothalamic energy homeostasis circuitry and limbic circuitry in the performance of a food reward task. Given the role of the medial hypothalamus in regulation of energy balance, our study suggests that this circuitry may contribute to reward regulation within the larger context of energy homeostasis.

scholarly journals Double-Dissociation of the Catecholaminergic Modulation of Synaptic Transmission in the Oval Bed Nucleus of the Stria Terminalis

2011 ◽  
Vol 105 (1) ◽  
pp. 145-153 ◽  
Author(s):  
Michal Krawczyk ◽  
François Georges ◽  
Robyn Sharma ◽  
Xenos Mason ◽  
Amandine Berthet ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Drugs Of Abuse ◽  
Brain Slices ◽  
Stria Terminalis ◽  
Dependent Manner ◽  
Adult Rats ◽  
Bed Nucleus ◽  
Inhibitory Synaptic Transmission ◽  
Double Dissociation ◽  
Dose Dependent

The bed nucleus of the stria terminalis (BST) is a cluster of nuclei within the extended amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. The subnuclei of the BST coordinate autonomic, neuroendocrine, and somato-motor functions and receive robust neuromodulatory monoaminergic afferents, including 5-HT-, noradrenaline (NA)-, and dopamine (DA)-containing terminals. In contrast to 5-HT and NA, little is known about how DA modulates neuronal activity or synaptic transmission in the BST. DA-containing afferents to the BST originate in the ventral tegmental area, the periaqueducal gray, and the retrorubral field. They form a fairly diffuse input to the dorsolateral BST with dense terminal fields in the oval (ovBST) and juxtacapsular (jxBST) nuclei. The efferent-afferent connectivity of the BST suggests that it may play a key role in motivated behaviors, consistent with recent evidence that the dorsolateral BST is a target for drugs of abuse. This study describes the effects of DA on synaptic transmission in the ovBST. Whole cell voltage clamp recordings were performed on ovBST neurons in brain slices from adult rats in the presence or absence of exogenous DA and receptor-targeted agonists and antagonists. The results showed that DA selectively and exclusively reduced inhibitory synaptic transmission in the ovBST in a dose-dependent and D2-like dopamine receptor-dependent manner. DA also modulated excitatory synaptic transmission in a dose-dependent dependent manner. However, this effect was mediated by α2-noradrenergic receptors. Thus these data reveal a double dissociation in catecholaminergic regulation of excitatory and inhibitory synaptic transmission in the ovBST and may shed light on the mechanisms involved in neuropathological behaviors such as stress-induced relapse to consumption of drugs of abuse.

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