GABA uptake regulates cortical excitability via cell type–specific tonic inhibition

2003 ◽  
Vol 6 (5) ◽  
pp. 484-490 ◽  
Author(s):  
Alexey Semyanov ◽  
Matthew C. Walker ◽  
Dimitri M. Kullmann
Keyword(s):  
Cortical Excitability ◽  
Tonic Inhibition ◽  
Gaba Uptake ◽  
Cell Type ◽  
Cell Type Specific

scholarly journals Cell Type–Specific GABAA Receptor–Mediated Tonic Inhibition in Mouse Neocortex

2008 ◽  
Vol 100 (1) ◽  
pp. 526-532 ◽  
Author(s):  
Irina Vardya ◽  
Kim R. Drasbek ◽  
Zita Dósa ◽  
Kimmo Jensen
Keyword(s):  
Fluorescent Protein ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Tonic Inhibition ◽  
Synaptic Activity ◽  
Inhibitory Input ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific ◽  
Green Fluorescent

Activity of extrasynaptic GABAA receptors mediating tonic inhibition is thought to play an important role for the excitability of the mammalian cerebral cortex. However, little is known about the cell type–specific expression of tonic inhibition in particular types of cortical interneurons. Here, we used transgenic mice expressing green fluorescent protein (GFP) in somatostatin-positive (SOM) interneurons and investigated tonic inhibition in SOM interneurons versus pyramidal cells in neocortical layers 2/3. In brain slices, pyramidal cells showed a tonic current of 66 ± 19 pA in response to the δ-subunit selective GABAA agonist THIP (1 μM). On the other hand, tonic inhibition was absent in SOM interneurons (8 ± 1 pA) in response to THIP. As opposed to pyramidal cells, SOM interneurons were also insensitive to the δ-subunit preferring neurosteroid allotetrahydrodeoxycorticosterone (THDOC) (100 nM) and to elevated endogenous GABA levels in the slice. Finally, SOM interneurons received only 45% of the phasic charge transfer during GABAA receptor–mediated synaptic activity compared with pyramidal cells. Altogether, our study indicates that SOM interneurons receive relatively weak inhibitory input and cannot be brought under the influence of tonic inhibition.

scholarly journals Cell-type specific regulation of cortical excitability through the allatostatin receptor system

2012 ◽  
Vol 6 ◽  
Author(s):  
Taruna Ikrar ◽  
Yulin Shi ◽  
Tomoko Velasquez ◽  
Martyn Goulding ◽  
Xiangmin Xu
Keyword(s):  
Cortical Excitability ◽  
Cell Type ◽  
Receptor System ◽  
Cell Type Specific ◽  
Specific Regulation

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration
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