scholarly journals The quest for action potentials in C. elegans neurons hits a plateau

2009 ◽  
Vol 12 (4) ◽  
pp. 377-378 ◽  
Author(s):  
Shawn R Lockery ◽  
Miriam B Goodman
Keyword(s):  
Action Potentials ◽  
C Elegans

scholarly journals Reply to “First report of action potentials in a C. elegans neuron is premature”

2009 ◽  
Vol 12 (4) ◽  
pp. 366-366 ◽  
Author(s):  
Jerry E Mellem ◽  
Penelope J Brockie ◽  
David M Madsen ◽  
Andres V Maricq
Keyword(s):  
Action Potentials ◽  
First Report ◽  
C Elegans

scholarly journals First report of action potentials in a C. elegans neuron is premature

2009 ◽  
Vol 12 (4) ◽  
pp. 365-366 ◽  
Author(s):  
Shawn R Lockery ◽  
Miriam B Goodman ◽  
Serge Faumont
Keyword(s):  
Action Potentials ◽  
First Report ◽  
C Elegans

scholarly journals Action potentials contribute to neuronal signaling in C. elegans

2008 ◽  
Vol 11 (8) ◽  
pp. 865-867 ◽  
Author(s):  
Jerry E Mellem ◽  
Penelope J Brockie ◽  
David M Madsen ◽  
Andres V Maricq
Keyword(s):  
Action Potentials ◽  
Neuronal Signaling ◽  
C Elegans

scholarly journals The C.elegans AWA Olfactory Neuron Fires Calcium-Mediated All-or-None Action Potentials

2018 ◽  
Author(s):  
Qiang Liu ◽  
Philip B. Kidd ◽  
May Dobosiewicz ◽  
Cornelia I. Bargmann
Keyword(s):  
Calcium Imaging ◽  
Action Potentials ◽  
Neural Coding ◽  
Patch Clamp Recording ◽  
Olfactory Neurons ◽  
C Elegans ◽  
Coding Schemes ◽  
Current Voltage ◽  
Ion Substitution ◽  
Specialized Function

SummaryWe find, unexpectedly, that C. elegans neurons can encode information through regenerative all-or-none action potentials. In a survey of current-voltage relationships in C. elegans neurons, we discovered that AWA olfactory neurons generate membrane potential spikes with defining characteristics of action potentials. Ion substitution experiments, pharmacology, and mutant analysis identified a voltage-gated CaV1 calcium channel and a Shaker-type potassium channel that underlie action potential dynamics in AWA. Simultaneous patch-clamp recording and calcium imaging in AWA revealed spike-associated calcium signals that were also observed after odor stimulation of intact animals, suggesting that natural odor stimuli induce AWA action potentials. The stimulus regimes that elicited action potentials match AWA’s proposed specialized function in climbing odor gradients. Our results provide evidence that C. elegans can use digital as well as analog coding schemes, expand the computational repertoire of its nervous system, and inform future modeling of its neural coding and network dynamics.

scholarly journals EGL-19 and EXP-2 Ion Channels Modelling within C. Elegans Pharyngeal Muscle Cell Allows Reproduction of CA2+ Driven Action Potentials, Both Single Events and Trains

2017 ◽  
Author(s):  
Andrey Yu. Palyanov ◽  
Khristina V. Samoilova ◽  
Natalia V. Palyanova
Keyword(s):  
Ion Channels ◽  
Muscle Cell ◽  
Action Potentials ◽  
Computational Models ◽  
Signal Transmission ◽  
Open Science ◽  
Time Profile ◽  
Simulation Environment ◽  
Pharyngeal Muscle ◽  
C Elegans

One of the current problems at the interface between neuroscience, biophysics, and computational modeling is the reverse-engineering and reproduction of Caenorhabditis elegans using computer simulation. The aim of our research was to develop the computational models and techniques for solving this problem while participating in the international open science OpenWorm Project. We have suggested models of a typical C. elegans neuron and a pharyngeal muscle cell, which were constructed and optimized using the NEURON simulation environment. The available experimental data about EGL-19 and EXP-2 ion channels allowed the model of a muscle to reproduce the action potential time profile correctly. Also, the model of a neuron reproduces quite accurately the mechanism of neural signal transmission based on passive propagation. We believe our models to be promising for better representing the specifics of various nervous and muscular cell classes when adding the corresponding ion channel models. Moreover, they can be used to construct the networks of such elements.

scholarly journals Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells

2010 ◽  
Vol 589 (1) ◽  
pp. 101-117 ◽  
Author(s):  
P. Liu ◽  
Q. Ge ◽  
B. Chen ◽  
L. Salkoff ◽  
M. I. Kotlikoff ◽  
...  
Keyword(s):  
Action Potentials ◽  
Body Wall ◽  
Muscle Cells ◽  
Body Wall Muscle ◽  
Genetic Dissection ◽  
Ion Currents ◽  
C Elegans

scholarly journals C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program

2021 ◽  
Author(s):  
Jingyuan Jiang ◽  
Yifan Su ◽  
Rulin Zhang ◽  
Haiwen Li ◽  
Louis Tao ◽  
...  
Keyword(s):  
Nervous System ◽  
Motor Neurons ◽  
Action Potentials ◽  
Motor Program ◽  
Whole Body ◽  
Long Distance ◽  
C Elegans ◽  
Neural Imaging ◽  
Negative Spike ◽  
Behavior Tracking

The C. elegans nervous system was thought to be strictly analog, constituted solely by graded neurons. We recently discovered neuronal action potentials in the sensory neuron AWA; however, the extent to which the C. elegans nervous system relies on analog or digital neural signaling and coding is unclear. Here we report that the enteric motor neurons AVL and DVB fire all-or-none calcium-mediated action potentials that play essential roles in the rhythmic defecation behavior in C. elegans. Both AVL and DVB synchronously fire giant action potentials to faithfully execute all-or-none expulsion following the intestinal pacemaker. AVL fires unusual compound action potentials with each positive calcium-mediated spike followed by a potassium-mediated negative spike. The depolarizing calcium spikes in AVL are mediated by a CaV2 calcium channel UNC-2, while the negative potassium spikes are mediated by a repolarization-activated potassium channel EXP-2. Whole-body behavior tracking and simultaneous neural imaging in free-moving animals suggest that action potentials initiated in AVL in the head propagate along its axon to the tail and activate DVB through the INX-1 gap junction. Synchronized action potential spikes between AVL and DVB, as well as the negative spike and long-lasting afterhyperpolarization in AVL, play an important function in executing expulsion behavior. This work provides the first evidence that in addition to sensory coding, C. elegans motor neurons also use digital coding scheme to perform specific functions including long-distance communication and temporal synchronization, suggesting further, unforeseen electrophysiological diversity remains to be discovered in the C. elegans nervous system.

scholarly journals C. elegans AWA Olfactory Neurons Fire Calcium-Mediated All-or-None Action Potentials

Cell ◽  
2018 ◽  
Vol 175 (1) ◽  
pp. 57-70.e17 ◽  
Author(s):  
Qiang Liu ◽  
Philip B. Kidd ◽  
May Dobosiewicz ◽  
Cornelia I. Bargmann
Keyword(s):  
Action Potentials ◽  
Olfactory Neurons ◽  
C Elegans
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