scholarly journals Activation of raphe nuclei triggers rapid and distinct effects on parallel olfactory bulb output channels

2016 ◽  
Vol 19 (2) ◽  
pp. 271-282 ◽  
Author(s):  
Vikrant Kapoor ◽  
Allison C Provost ◽  
Prateek Agarwal ◽  
Venkatesh N Murthy
Keyword(s):  
Olfactory Bulb ◽  
Raphe Nuclei ◽  
Raphé Nuclei

scholarly journals Serotonin modulates the population activity profile of olfactory bulb external tufted cells

2012 ◽  
Vol 107 (1) ◽  
pp. 473-483 ◽  
Author(s):  
Shaolin Liu ◽  
Jason L. Aungst ◽  
Adam C. Puche ◽  
Michael T. Shipley
Keyword(s):  
Olfactory Bulb ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Inhibitory Neurons ◽  
Raphe Nuclei ◽  
Population Activity ◽  
Odor Coding ◽  
Inward Current ◽  
Tufted Cells ◽  
Raphé Nuclei

Serotonergic neurons in the raphe nuclei constitute one of the most prominent neuromodulatory systems in the brain. Projections from the dorsal and median raphe nuclei provide dense serotonergic innervation of the glomeruli of olfactory bulb. Odor information is initially processed by glomeruli, thus serotonergic modulation of glomerular circuits impacts all subsequent odor coding in the olfactory system. The present study discloses that serotonin (5-HT) produces excitatory modulation of external tufted (ET) cells, a pivotal neuron in the operation of glomerular circuits. The modulation is due to a transient receptor potential (TRP) channel-mediated inward current induced by activation of 5-HT2A receptors. This current produces membrane depolarization and increased bursting frequency in ET cells. Interestingly, the magnitude of the inward current and increased bursting inversely correlate with ET cell spontaneous (intrinsic) bursting frequency: slower bursting ET cells are more strongly modulated than faster bursting cells. Serotonin thus differentially impacts ET cells such that the mean bursting frequency of the population is increased. This centrifugal modulation could impact odor processing by: 1) increasing ET cell excitatory drive on inhibitory neurons to increase presynaptic inhibition of olfactory sensory inputs and postsynaptic inhibition of mitral/tufted cells; and/or 2) coordinating ET cell bursting with exploratory sniffing frequencies (5–8 Hz) to facilitate odor coding.

scholarly journals Divergent innervation of the olfactory bulb by distinct raphe nuclei

2015 ◽  
Vol 523 (5) ◽  
pp. 805-813 ◽  
Author(s):  
Raphael Steinfeld ◽  
Jan T. Herb ◽  
Rolf Sprengel ◽  
Andreas T. Schaefer ◽  
Izumi Fukunaga
Keyword(s):  
Olfactory Bulb ◽  
Raphe Nuclei ◽  
Raphé Nuclei

scholarly journals Cell-Type-Specific Modulation of Sensory Responses in Olfactory Bulb Circuits by Serotonergic Projections from the Raphe Nuclei

2016 ◽  
Vol 36 (25) ◽  
pp. 6820-6835 ◽  
Author(s):  
Daniela Brunert ◽  
Yusuke Tsuno ◽  
Markus Rothermel ◽  
Michael T. Shipley ◽  
Matt Wachowiak
Keyword(s):  
Olfactory Bulb ◽  
Raphe Nuclei ◽  
Cell Type ◽  
Cell Type Specific ◽  
Sensory Responses ◽  
Raphé Nuclei

Firing pattern and location of respiratory neurons in cat medullary raphe nuclei

1993 ◽  
Vol 161 (2) ◽  
pp. 149-152 ◽  
Author(s):  
Masae Hosogai ◽  
Satoshi Matsuo ◽  
Shozo Nakao
Keyword(s):  
Firing Pattern ◽  
Raphe Nuclei ◽  
Respiratory Neurons ◽  
Medullary Raphe ◽  
Raphé Nuclei
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