Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

2015 ◽  
Vol 18 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Ciaran Murphy-Royal ◽  
Julien P Dupuis ◽  
Juan A Varela ◽  
Aude Panatier ◽  
Benoît Pinson ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Surface Diffusion ◽  
Glutamate Transporters

scholarly journals Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission

2017 ◽  
Vol 95 (11) ◽  
pp. 2140-2151 ◽  
Author(s):  
Ciaran Murphy-Royal ◽  
Julien Dupuis ◽  
Laurent Groc ◽  
Stéphane H. R. Oliet
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Transporters ◽  
The Brain

Glutamate transporters: confining runaway excitation by shaping synaptic transmission

2007 ◽  
Vol 8 (12) ◽  
pp. 935-947 ◽  
Author(s):  
Anastassios V. Tzingounis ◽  
Jacques I. Wadiche
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Transporters

scholarly journals Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters

Neuron ◽  
2017 ◽  
Vol 96 (1) ◽  
pp. 73-80.e4 ◽  
Author(s):  
Hsin-Wei Lu ◽  
Timothy S. Balmer ◽  
Gabriel E. Romero ◽  
Laurence O. Trussell
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Transporters

scholarly journals pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract

2013 ◽  
Vol 110 (2) ◽  
pp. 368-377 ◽  
Author(s):  
Rafiq Huda ◽  
Donald R. McCrimmon ◽  
Marco Martina
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Uptake ◽  
Glutamate Release ◽  
Glutamate Transporters ◽  
Functional Expression ◽  
Repetitive Stimulation ◽  
Solitary Tract ◽  
Extracellular Acidification ◽  
Sensory Afferents ◽  
Selective Membrane

The nucleus of the solitary tract (NTS) is the major site for termination of visceral sensory afferents contributing to homeostatic regulation of, for example, arterial pressure, gastric motility, and breathing. Whereas much is known about how different neuronal populations influence these functions, information about the role of glia remains scant. In this article, we propose that glia may contribute to NTS functions by modulating excitatory neurotransmission. We found that acidification (pH 7.0) depolarizes NTS glia by inhibiting K+-selective membrane currents. NTS glia also showed functional expression of voltage-sensitive glutamate transporters, suggesting that extracellular acidification regulates synaptic transmission by compromising glial glutamate uptake. To test this hypothesis, we evoked glutamatergic slow excitatory potentials (SEPs) in NTS neurons with repetitive stimulation (20 pulses at 10 Hz) of the solitary tract. This SEP depends on accumulation of glutamate following repetitive stimulation, since it was potentiated by blocking glutamate uptake with dl- threo-β-benzyloxyaspartic acid (TBOA) or a glia-specific glutamate transport blocker, dihydrokainate (DHK). Importantly, extracellular acidification (pH 7.0) also potentiated the SEP. This effect appeared to be mediated through a depolarization-induced inhibition of glial transporter activity, because it was occluded by TBOA and DHK. In agreement, pH 7.0 did not directly alter d-aspartate-induced responses in NTS glia or properties of presynaptic glutamate release. Thus acidification-dependent regulation of glial function affects synaptic transmission within the NTS. These results suggest that glia play a modulatory role in the NTS by integrating local tissue signals (such as pH) with synaptic inputs from peripheral afferents.

scholarly journals Glutamate Transporters Contribute to the Time Course of Synaptic Transmission in Cerebellar Granule Cells

1999 ◽  
Vol 19 (21) ◽  
pp. 9663-9673 ◽  
Author(s):  
Linda S. Overstreet ◽  
Gregory A. Kinney ◽  
Ying-Bing Liu ◽  
Daniela Billups ◽  
N. Traverse Slater
Keyword(s):  
Synaptic Transmission ◽  
Time Course ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Glutamate Transporters ◽  
Cerebellar Granule

Role of glutamate transporters in corticostriatal synaptic transmission

Neuroscience ◽  
2009 ◽  
Vol 158 (4) ◽  
pp. 1608-1615 ◽  
Author(s):  
C. Beurrier ◽  
G. Bonvento ◽  
L. Kerkerian-Le Goff ◽  
P. Gubellini
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Transporters
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