Optogenetic pharmacology for control of native neuronal signaling proteins

Nature Neuroscience ◽

10.1038/nn.3424 ◽

2013 ◽

Vol 16 (7) ◽

pp. 816-823 ◽

Cited By ~ 143

Author(s):

Richard H Kramer ◽

Alexandre Mourot ◽

Hillel Adesnik

Keyword(s):

Signaling Proteins ◽

Neuronal Signaling

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A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression

Frontiers in Oncology ◽

10.3389/fonc.2019.00289 ◽

2019 ◽

Vol 9 ◽

Cited By ~ 7

Author(s):

Markus Hartl ◽

Rainer Schneider

Keyword(s):

Tumor Suppression ◽

Signaling Proteins ◽

Neuronal Signaling

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Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication

Toxicology ◽

10.1016/j.tox.2011.09.005 ◽

2011 ◽

Vol 290 (2-3) ◽

pp. 195-202 ◽

Cited By ~ 12

Author(s):

G. RamaRao ◽

B.K. Bhattacharya ◽

Subodh Kumar ◽

C.K. Waghmare

Keyword(s):

Gene Expression ◽

Signaling Proteins ◽

Neuronal Signaling

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Review for "Expression profiling of precuneus layer III cathepsin D‐immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability"

10.1002/cne.24929/v2/review1 ◽

2020 ◽

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Expression Profiling ◽

Cathepsin D ◽

Pyramidal Neurons ◽

Neuronal Signaling

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Faculty Opinions recommendation of Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1008482.167012 ◽

2002 ◽

Author(s):

Eric Long

Keyword(s):

Signaling Proteins

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Faculty Opinions recommendation of Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092397.548772 ◽

2007 ◽

Author(s):

Charlotte Teunissen

Keyword(s):

Signaling Proteins

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Faculty Opinions recommendation of Identification and characterization of a general nuclear translocation signal in signaling proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1122980.580252 ◽

2008 ◽

Author(s):

Jean-Antoine Girault

Keyword(s):

Nuclear Translocation ◽

Signaling Proteins ◽

Identification And Characterization

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Faculty Opinions recommendation of Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3767956.3494054 ◽

2010 ◽

Author(s):

Stephen Schwartz

Keyword(s):

G Protein ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

G Protein Signaling ◽

Signaling Proteins ◽

Protein Signaling

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Faculty Opinions recommendation of Roles for regulator of G protein signaling proteins in synaptic signaling and plasticity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726009695.793567588 ◽

2019 ◽

Author(s):

Michael Andresen

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Signaling Proteins ◽

Protein Signaling ◽

Synaptic Signaling

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Notch Signaling Proteins: Legitimate Targets for Cancer Therapy

Current Protein and Peptide Science ◽

10.2174/1389210204916282037 ◽

2010 ◽

Vol 999 (999) ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Zhiwei Wang ◽

Yiwei Li ◽

Fazlul H. Sarkar

Keyword(s):

Cancer Therapy ◽

Notch Signaling ◽

Signaling Proteins

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Revealing the Roles of Keratin 8/18-Associated Signaling Proteins Involved in the Development of Hepatocellular Carcinoma

International Journal of Molecular Sciences ◽

10.3390/ijms22126401 ◽

2021 ◽

Vol 22 (12) ◽

pp. 6401

Author(s):

Younglan Lim ◽

Nam-On Ku

Keyword(s):

Hepatocellular Carcinoma ◽

Transcription Factors ◽

Liver Damage ◽

Cell Shape ◽

Mutation Frequency ◽

Cytoskeletal Proteins ◽

Signaling Proteins ◽

Intermediate Filament Proteins ◽

Keratin 8 ◽

Keratin 18

Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.

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