scholarly journals Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

2013 ◽  
Vol 16 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Francesco Ferrini ◽  
Tuan Trang ◽  
Theresa-Alexandra M Mattioli ◽  
Sophie Laffray ◽  
Thomas Del'Guidice ◽  
...  
Keyword(s):  
Morphine Hyperalgesia

scholarly journals Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

Pain ◽  
2013 ◽  
Vol 154 (7) ◽  
pp. 978-986 ◽  
Author(s):  
Joshua W. Little ◽  
Salvatore Cuzzocrea ◽  
Leesa Bryant ◽  
Emanuela Esposito ◽  
Timothy Doyle ◽  
...  
Keyword(s):  
Antinociceptive Tolerance ◽  
Morphine Hyperalgesia ◽  
Neuroimmune Activation

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

2010 ◽  
Vol 132 (1) ◽  
pp. 200-205 ◽  
Author(s):  
Saeed Esmaeili-Mahani ◽  
Maryam Rezaeezadeh-Roukerd ◽  
Khadije Esmaeilpour ◽  
Mehdi Abbasnejad ◽  
Bahram Rasoulian ◽  
...  
Keyword(s):  
Olea Europaea ◽  
Leaf Extract ◽  
Antinociceptive Activity ◽  
Morphine Analgesia ◽  
Olea Europaea L ◽  
Morphine Hyperalgesia ◽  
Olea Europaéa

Moxonidine, a Selective Imidazoline–α2-Adrenergic Receptor Agonist, Produces Spinal Synergistic Antihyperalgesia with Morphine in Nerve-injured Mice

2000 ◽  
Vol 93 (3) ◽  
pp. 765-773 ◽  
Author(s):  
Carolyn A. Fairbanks ◽  
H. Oanh Nguyen ◽  
Brent M. Grocholski ◽  
George L. Wilcox
Keyword(s):  
Neuropathic Pain ◽  
Dose Response ◽  
Adrenergic Receptor ◽  
Mechanical Hyperalgesia ◽  
Mechanical Stimuli ◽  
Response Curves ◽  
Plantar Surface ◽  
Pain Models ◽  
Dose Response Curves ◽  
Morphine Hyperalgesia

Background Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rodents. In contrast, morphine potency and efficacy decreases in states of neuropathic pain, both in rodents and in humans, but may be restored or enhanced by coadministration of morphine with alpha2-adrenergic receptor-selective analgesics. The current experiments extend the evaluation of opioid-coadjuvant interactions in neuropathic subjects by testing the respective antihyperalgesic interactions of moxonidine and clonidine with morphine in a test of mechanical hyperalgesia. Methods Nerve-injured mice (Chung model) were spinally administered moxonidine, clonidine, morphine, and the combinations moxonidine-morphine and clonidine-morphine. Hyperalgesia was detected by von Frey monofilament stimulation (3.3 mN) to the hind paws (plantar surface). The ED50 values were calculated and the interactions tested by isobolographic analysis. Results In nerve-injured mice, moxonidine, clonidine, and morphine all dose-dependently inhibited mechanical hyperalgesia. Furthermore, the combinations of moxonidine-morphine and clonidine-morphine resulted in substantial leftward shifts in the dose-response curves compared with those of each agonist administered separately. The calculated ED50 values of the dose-response curves of these combinations were significantly lower than their corresponding theoretical additive ED50 values. These results confirmed that both interactions were synergistic. Conclusions Moxonidine and clonidine both synergize with morphine to inhibit paw withdrawal from nociceptive mechanical stimuli in nerve-injured mice.

Morphine hyperalgesia: A case report

2003 ◽  
Vol 20 (6) ◽  
pp. 459-461 ◽  
Author(s):  
George R. Wilson ◽  
Gary M. Reisfield
Keyword(s):  
Case Report ◽  
Morphine Hyperalgesia
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