scholarly journals miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

2009 ◽  
Vol 12 (4) ◽  
pp. 399-408 ◽  
Author(s):  
Li-Chun Cheng ◽  
Erika Pastrana ◽  
Masoud Tavazoie ◽  
Fiona Doetsch
Keyword(s):  
Stem Cell ◽  
Adult Neurogenesis ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Cell Niche

scholarly journals Fractone bulbs derive from ependymal cells and their laminin composition influence the stem cell niche in the subventricular zone

2016 ◽  
Author(s):  
Marcos Assis Nascimento ◽  
Lydia Sorokin ◽  
Tatiana Coelho-Sampaio
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Neural Stem Cell ◽  
Adult Neurogenesis ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Ependymal Cells ◽  
Cell Niche

AbstractFractones are extracellular matrix structures in the neural stem cell niche of the subventricular zone (SVZ), where they appear as round deposits named bulbs or thin branching lines called stems. Their cellular origin and what determines their localization at this site is poorly studied and it remains unclear whether they influence neural stem and progenitor cells formation, proliferation and/or maintenance. To address these questions, we analyzed whole mount preparations of the lateral ventricle by confocal microscopy using different extracellular matrix and cell markers. We found that bulbs are rarely connected to stems and that they contain laminin α5 and α2 chains, respectively. Fractone bulbs were profusely distributed throughout the SVZ and appeared associated with the center of pinwheels, a critical site for adult neurogenesis. We demonstrate that bulbs appear at the apical membrane of ependymal cells at the end of the first week after birth. The use of transgenic mice lacking laminin α5 gene expression (Lama5) in endothelium and in FoxJ1-expressing ependymal cells, revealed ependymal cells as the source of laminin α5-containing fractone bulbs. Loss of laminin α5 from bulbs correlated with a 60% increase in cell proliferation, as determined by PH3 staining, and with a selective reduction in the number of quiescent neural stem cells in the SVZ. These results indicate that fractones are a key component of the SVZ and suggest that laminin α5 modulates the physiology of the neural stem cell niche.Significance StatementOur work unveils key aspects of fractones, extracellular matrix structures present in the SVZ that still lack a comprehensive characterization. We show that fractones extensively interact with neural stem cells, whereas some of them are located precisely at pinwheel centers, which are hotspots for adult neurogenesis. Our results also demonstrate that fractones increase in size during aging and that their interactions with NSPCs become more complex in old mice. Lastly, we show that fractone bulbs are produced by ependymal cells and that their laminin content regulates neural stem cells.

Adult Neurogenesis in the Crayfish Brain: The Hematopoietic Anterior Proliferation Center Has Direct Access to the Brain and Stem Cell Niche

2013 ◽  
Vol 22 (7) ◽  
pp. 1027-1041 ◽  
Author(s):  
Paula Grazielle Chaves da Silva ◽  
Jeanne L. Benton ◽  
David C. Sandeman ◽  
Barbara S. Beltz
Keyword(s):  
Stem Cell ◽  
Adult Neurogenesis ◽  
Stem Cell Niche ◽  
Direct Access ◽  
Cell Niche ◽  
The Brain

Age-Related Changes to the Subventricular Zone Stem Cell Niche

2015 ◽  
pp. 35-68
Author(s):  
Matthew B. Eastman ◽  
Rebecca L. Acabchuk ◽  
Joanne C. Conover
Keyword(s):  
Stem Cell ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Age Related ◽  
Cell Niche ◽  
Age Related Changes

scholarly journals The Molecular Profiles of Neural Stem Cell Niche in the Adult Subventricular Zone

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50501 ◽  
Author(s):  
Cheol Lee ◽  
Jingqiong Hu ◽  
Sherry Ralls ◽  
Toshio Kitamura ◽  
Y. Peng Loh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Neural Stem Cell Niche ◽  
Molecular Profiles ◽  
Cell Niche
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