Unexpected finding provides new understanding of liver regeneration

2019 ◽  
Author(s):  
Rieko Kawabata
Keyword(s):  
Liver Regeneration ◽  
Unexpected Finding

Impaired liver regeneration in GBA2-deficient mice

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
ER Almajan ◽  
R Sandhoff ◽  
MC Gonzales ◽  
R Büttner ◽  
S Weber ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Impaired Liver ◽  
Deficient Mice

ALR expression indicates liver regeneration upon distinct tissue damage

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
R Dayoub ◽  
C Dorn ◽  
C Hackl ◽  
O Stölzing ◽  
WE Thasler ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Tissue Damage

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
F Pinna ◽  
S Tuncay ◽  
LA D'Alessandro ◽  
R Gauges ◽  
M Bissinger ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Priming Phase

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
W Hu ◽  
YA Nevzorova ◽  
U Haas ◽  
P Sicinski ◽  
M Barbacid ◽  
...  
Keyword(s):  
Dna Replication ◽  
Liver Regeneration ◽  
Cyclin E1

Free Protein S Deficiency Is a Risk Factor for Venous Thrombosis

1997 ◽  
Vol 78 (05) ◽  
pp. 1343-1346 ◽  
Author(s):  
Elena M Faioni ◽  
Carla Valsecchi ◽  
Alessandra Palla ◽  
Emanuela Taioli ◽  
Cristina Razzari ◽  
...  
Keyword(s):  
Risk Factor ◽  
Relative Risk ◽  
Venous Thrombosis ◽  
Protein S ◽  
Unexpected Finding ◽  
Reference Ranges ◽  
Protein S Deficiency ◽  
Men And Women ◽  
Free Protein ◽  
S Deficiency

SummaryA recent study suggests that protein S deficiency is not a risk factor for venous thrombosis. Since this unexpected finding would have important clinical implications if confirmed, we performed a case-control study with the aim to determine the prevalence of protein S deficiency in patients with thrombosis and in healthy individuals taken from the general population and the relative risk of thrombosis in protein S-deficient patients. Free protein S concentration was measured in 327 consecutive patients with at least one venous thrombotic episode and in 317 age- and sex-matched control individuals. Different normal reference ranges were obtained and adopted for men and women. Protein S deficiency was found in 3.1% (95% Cl: 1.5-5.2) of patients and in 1.3% of controls (95% Cl: 0.3-2.8). Ten patients and 4 control subjects had protein S deficiency, which determined a relative risk of thrombosis (sex- and age-adjusted odds ratio) of 2.4 (95% Cl: 0.8-7.9). When men and women were analyzed separately, the risk was 5.0 (95% CI: 0.6-43.6) and 1.6 (95% Cl: 0.4-6.7) respectively. PS-deficient men had more thrombotic episodes than women and later in life. Multivariate analysis established that sex was an independent determinant of the number of episodes, as was age, while PS deficiency was not. However sex and PS deficiency status were both determinants of age at first thrombotic episode.

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