Arab women suffer more aggressive breast cancer

2013 ◽  
Author(s):  
Aisha El-Awady
Keyword(s):  
Breast Cancer ◽  
Arab Women ◽  
Aggressive Breast Cancer

scholarly journals Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. Biedulska ◽  
P. Jakóbczyk ◽  
M. Sosnowska ◽  
B. Dec ◽  
A. Muchlińska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Polymeric Micelles ◽  
Black Phosphorus ◽  
Environmental Stability ◽  
Breast Cancer Cell Lines ◽  
The Novel ◽  
Ft Ir ◽  
Dose Dependent ◽  
Aggressive Breast Cancer

AbstractThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined by RP-HPLC, microscopic (TEM and SEM) and spectroscopic (FT-IR and Raman) techniques as well supported by ab-initio modelling. The cell and dose dependent cytotoxicity of FLBP and its bioconjugates was evaluated against HB2, MCF-7 and MDA-MB-231 cell lines. Functionalisation allowed not only for improvement of environmental stability, but also enhances therapeutic effect by abolished the cytotoxicity of FLBP against HB2 cell line. Moreover, modification of FLBP with PLL caused increase of selectivity against highly aggressive breast cancer cell lines. Results indicate the future prospect application of black phosphorus nanosheets as nanocarrier, considering its unique features synergistically with conjugated polymeric micelles.

scholarly journals Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yahui Ding ◽  
Xiaoping Chen ◽  
Can Liu ◽  
Weizhi Ge ◽  
Qin Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Small Molecule ◽  
Mode Of Action ◽  
Rna Silencing ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Parent Compound ◽  
Aggressive Breast Cancer

Abstract Background TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. Methods Different inhibitors were used to study the cell death manner of DMOCPTL. RNA silencing was used to evaluate the functions of GPX4 in ferroptosis and apoptosis of TNBC cells and functions of EGR1 in apoptosis. Immunohistochemical assay of tissue microarray were used for investigating correlation of GPX4 and EGR1 with TNBC. Computer-aided docking and small molecule probe were used for study the binding of DMOCPTL with GPX4. Results DMOCPTL, a derivative of natural product parthenolide, exhibited about 15-fold improvement comparing to that of the parent compound PTL for TNBC cells. The cell death manner assay showed that the anti-TNBC effect of DMOCPTL mainly by inducing ferroptosis and apoptosis through ubiquitination of GPX4. The probe of DMOCPTL assay indicated that DMOCPTL induced GPX4 ubiquitination by directly binding to GPX4 protein. To the best of our knowledge, this is the first report of inducing ferroptosis through ubiquitination of GPX4. Moreover, the mechanism of GPX4 regulation of apoptosis is still obscure. Here, we firstly reveal that GPX4 regulated mitochondria-mediated apoptosis through regulation of EGR1 in TNBC cells. Compound 13, the prodrug of DMOCPTL, effectively inhibited the growth of breast tumor and prolonged the lifespan of mice in vivo, and no obvious toxicity was observed. Conclusions These findings firstly revealed novel manner to induce ferroptosis through ubiquitination of GPX4 and provided mechanism for GPX4 inducing mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Moreover, compound 13 deserves further studies as a lead compound with novel mode of action for ultimate discovery of effective anti-TNBC drug.

scholarly journals Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer

Cell Cycle ◽  
2012 ◽  
Vol 11 (15) ◽  
pp. 2780-2781 ◽  
Author(s):  
Fayaz Malik ◽  
Hasan Korkaya ◽  
Shawn G. Clouthier ◽  
Max S. Wicha
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Aggressive Breast Cancer

scholarly journals Do socioeconomic factors influence breast cancer screening practices among Arab women in Qatar?

BMJ Open ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. e005596-e005596 ◽  
Author(s):  
T. T. Donnelly ◽  
A.-H. Al Khater ◽  
M. G. Al Kuwari ◽  
S. B. Al-Bader ◽  
N. Al-Meer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Socioeconomic Factors ◽  
Breast Cancer Screening ◽  
Arab Women ◽  
Screening Practices

SERUM ANTI-THYROID ANTIBODIES (TAB) REPRESENTS A POSSIBLE PREDICTIVE PARAMETER IN HIGH AGGRESSIVE BREAST CANCER (BC)

Maturitas ◽  
2009 ◽  
Vol 63 ◽  
pp. S48
Author(s):  
E. Giustarini ◽  
E. Fiore ◽  
C. Mammoli ◽  
I. Muller ◽  
A. Pinchera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Thyroid Antibodies ◽  
Aggressive Breast Cancer
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