scholarly journals Bacteriophage evolution differs by host, lifestyle and genome

2017 ◽  
Vol 2 (9) ◽  
Author(s):  
Travis N. Mavrich ◽  
Graham F. Hatfull
Keyword(s):  
Bacteriophage Evolution

Bacteriophage evolution given spatial constraint

2007 ◽  
Vol 248 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Stephen T. Abedon ◽  
Rachel R. Culler
Keyword(s):  
Spatial Constraint ◽  
Bacteriophage Evolution

scholarly journals Molecular Insights into Bacteriophage Evolution toward Its Host

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1132
Author(s):  
Marina de Leeuw ◽  
Maayan Baron ◽  
Oshrit Ben David ◽  
Ariel Kushmaro
Keyword(s):  
Host Recognition ◽  
Broad Host Range ◽  
Tail Fiber ◽  
Whole Genome ◽  
Tail Fiber Protein ◽  
Gene Encoding ◽  
Evolution And Development ◽  
Adaptation Mechanisms ◽  
Fiber Protein ◽  
Bacteriophage Evolution

Bacteriophages (phages), viruses that infect bacteria, are considered to be highly host-specific. To add to the knowledge about the evolution and development of bacteriophage speciation toward its host, we conducted a 21-day experiment with the broad host-range bacteriophage Aquamicrobium phage P14. We incubated the phage, which was previously isolated and enriched with the Alphaproteobacteria Aquamicrobium H14, with the Betaproteobacteria Alcaligenaceae H5. During the experiment, we observed an increase in the phage’s predation efficacy towards Alcaligenaceae H5. Furthermore, genome analysis and the comparison of the bacteriophage’s whole genome indicated that rather than being scattered evenly along the genome, mutations occur in specific regions. In total, 67% of the mutations with a frequency higher than 30% were located in genes that encode tail proteins, which are essential for host recognition and attachment. As control, we incubated the phage with the Alphaproteobacteria Aquamicrobium H8. In both experiments, most of the mutations appeared in the gene encoding the tail fiber protein. However, mutations in the gene encoding the tail tubular protein B were only observed when the phage was incubated with Alcaligenaceae H5. This highlights the phage’s tail as a key player in its adaptation to different hosts. We conclude that mutations in the phage’s genome were mainly located in tail-related regions. Further investigation is needed to fully characterize the adaptation mechanisms of the Aquamicrobium phage P14.

scholarly journals Bacteriophage evolution drives Pseudomonas aeruginosa PAO1 biofilm diversification

2011 ◽  
Vol 12 (S11) ◽  
Author(s):  
Kerensa McElroy ◽  
Fabio Luciani ◽  
Janice Hui ◽  
Scott Rice ◽  
Torsten Thomas
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Pao1 ◽  
Bacteriophage Evolution

scholarly journals Order reduction for a model of marine bacteriophage evolution

2017 ◽  
Vol 811 ◽  
pp. 012010
Author(s):  
Silvia Pagliarini ◽  
Andrei Korobeinikov
Keyword(s):  
Order Reduction ◽  
Bacteriophage Evolution

scholarly journals Alternative phage-host interaction in Lactococcus lactis: the carrier state drives rapid evolution of phages

2020 ◽  
Author(s):  
Barbara Marcelli ◽  
Anne de Jong ◽  
Thomas Janzen ◽  
Jan Kok ◽  
Oscar P. Kuipers
Keyword(s):  
Life Cycle ◽  
Lactococcus Lactis ◽  
Starter Culture ◽  
Rapid Evolution ◽  
Laboratory Strain ◽  
Carrier State ◽  
Starter Cultures ◽  
Host Interaction ◽  
Bacteriophage Infection ◽  
Bacteriophage Evolution

AbstractLactococcus lactis is a lactic acid bacterium widely used as starter culture for the manufacture of fermented milk products like quark, buttermilk and cheese. Bacteriophage infection of starter cultures is one of the biggest causes of fermentation failure and, therefore, lactococcal phages have received great attention from the scientific community in the past decades. In this work we present evidence for the establishment of a carrier state life cycle (CSLC) by a bacteriophage belonging to the c2 species, in the model laboratory strain L. lactis MG1363. Our results show that infection of L. lactis MG1363 with a second, dissimilar, c2 bacteriophage can induce the CSLC phage to enter an active lytic life cycle. The viral progeny obtained after this infection is a mixed population of phages with differences in their genome sequences and host ranges, indicative of an extremely rapid evolution process. We discuss the possible implications of this phage-host interaction, both with respect to bacteriophage evolution and phage adaptation to different hosts.IMPORTANCEOur results broaden the current know-how on the yet poorly investigated phage-host interaction mechanism of CSLC, propose a new bacteriophage evolution mechanism, and demonstrate that the outcome of phage infections is possibly more intricate than presently acknowledged.

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