scholarly journals A microfluidic device for label-free, physical capture of circulating tumor cell clusters

2015 ◽  
Vol 12 (7) ◽  
pp. 685-691 ◽  
Author(s):  
A Fatih Sarioglu ◽  
Nicola Aceto ◽  
Nikola Kojic ◽  
Maria C Donaldson ◽  
Mahnaz Zeinali ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Microfluidic Device ◽  
Circulating Tumor Cell ◽  
Label Free ◽  
Cell Clusters

scholarly journals Design and production of a novel microfluidic device for the capture and isolation of circulating tumor cell clusters

AIP Advances ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 065313
Author(s):  
Sebastian W. Shaner ◽  
Jeffrey K. Allen ◽  
Martina Felderman ◽  
Evan T. Pasko ◽  
Carina D. Wimer ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Microfluidic Device ◽  
Circulating Tumor Cell ◽  
Cell Clusters ◽  
Design And Production

scholarly journals A microfluidic device for label-free isolation of tumor cell clusters from unprocessed blood samples

2019 ◽  
Vol 13 (4) ◽  
pp. 044111 ◽  
Author(s):  
Nabiollah Kamyabi ◽  
Jonathan Huang ◽  
Jaewon J. Lee ◽  
Vincent Bernard ◽  
Alexander Semaan ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Microfluidic Device ◽  
Label Free ◽  
Blood Samples ◽  
Cell Clusters

scholarly journals Novel approaches in cancer management with circulating tumor cell clusters

2019 ◽  
Vol 4 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Peyman Rostami ◽  
Navid Kashaninejad ◽  
Khashayar Moshksayan ◽  
Mohammad Said Saidi ◽  
Bahar Firoozabadi ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Cell Clusters ◽  
Cancer Management ◽  
Novel Approaches

ClearCell FX: A microfluidic system for label-free circulating tumor cell enrichment.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e22023-e22023 ◽  
Author(s):  
Andrew Wu ◽  
Ali Asgar Bhagat ◽  
Man Chun Leong ◽  
Chwee Teck Lim
Keyword(s):  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Microfluidic System ◽  
Label Free ◽  
Cell Enrichment

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

2015 ◽  
Vol 1 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Nicola Aceto ◽  
Mehmet Toner ◽  
Shyamala Maheswaran ◽  
Daniel A. Haber
Keyword(s):  
Tumor Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Circulating Tumor Cell ◽  
Mesenchymal Transition ◽  
Cell Clusters

scholarly journals Intratumor Heterogeneity and Circulating Tumor Cell Clusters

2017 ◽  
Author(s):  
Zafarali Ahmed ◽  
Simon Gravel
Keyword(s):  
Tumor Cell ◽  
Growth Parameters ◽  
Numerical Models ◽  
Circulating Tumor Cell ◽  
Intratumor Heterogeneity ◽  
Tumor Evolution ◽  
List Type ◽  
Cell Turnover ◽  
Cell Clusters ◽  
Spatial Trends

SummaryGenetic diversity plays a central role in tumor progression, metastasis, and resistance to treatment. Experiments are shedding light on this diversity at ever finer scales, but interpretation is challenging. Using recent progress in numerical models, we simulate macroscopic tumors to investigate the interplay between growth dynamics, microscopic composition, and circulating tumor cell cluster diversity. We find that modest differences in growth parameters can profoundly change microscopic diversity. Simple outwards expansion leads to spatially segregated clones and low diversity, as expected. However, a modest cell turnover can result in an increased number of divisions and mixing among clones resulting in increased microscopic diversity in the tumor core. Using simulations to estimate power to detect such spatial trends, we find that multiregion sequencing data from contemporary studies is marginally powered to detect the predicted effects. Slightly larger samples, improved detection of rare variants, or sequencing of smaller biopsies or circulating tumor cell clusters would allow one to distinguish between leading models of tumor evolution. The genetic composition of circulating tumor cell clusters, which can be obtained from non-invasive blood draws, is therefore informative about tumor evolution and its metastatic potential.HighlightsNumerical and theoretical models show interaction of front expansion, mutation, and clonal mixing in shaping tumor heterogeneity.Cell turnover increases intratumor heterogeneity.Simulated circulating tumor cell clusters and microbiopsies exhibit substantial diversity with strong spatial trends.Simulations suggest attainable sampling schemes able to distinguish between prevalent tumor growth models.

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