Cell-produced functional biomaterials

2014 ◽  
Vol 11 (5) ◽  
pp. 475-475
Keyword(s):  
Functional Biomaterials

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Variable Temperature ◽  
Inverse Temperature ◽  
Temperature Transition ◽  
Scanning Calorimetry ◽  
Design Synthesis ◽  
Inverse Temperature Transition ◽  
Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

Nanoscale Functional Biomaterials for Cancer Theranostics

2018 ◽  
Vol 25 (25) ◽  
pp. 2987-3000 ◽  
Author(s):  
Linying Liu ◽  
Xiaoshuang Li ◽  
Lei Chen ◽  
Xin Zhang
Keyword(s):  
Brain Cancer ◽  
Molecular Level ◽  
Functional Materials ◽  
Therapeutic Agents ◽  
Lower Side ◽  
Drug Delivery Vehicles ◽  
Functional Nanoparticles ◽  
Delivery Vehicles ◽  
Functional Biomaterials ◽  
Cancer Theranostics

Nanomedicine is widely developed in recent years. In nanomedicine system, nanoscale and nanostructured functional materials are used to manipulate the human biology systems at the molecular level for cancer imaging and therapy. New nanostructure based functional materials consist of nanoscale liposomes, spheres, micelles, capsules, emulsion, suspension and phamacosomes. Several functional nanoparticles such as lipidbased and polymer-based materials are demonstrated to be drug delivery vehicles and imaging agents. These materials are biodegradable, biocompatible and have better biodistribution, lower side effect and lower toxicity. In addition, hybrids with these materials coating provide uniquely electrical, optical and magnetic properties. This review discusses the research on the applications of functional materials, especially nanoparticles as imaging contrast agents, cancer therapeutic agents and multi-functional agents and this review focused on the theranostic integration treatments on liver cancer and brain cancer.

scholarly journals Correction: Growing a backbone – functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions

2021 ◽  
Vol 9 (6) ◽  
pp. 2322-2323
Author(s):  
Matthew D. Harmon ◽  
Daisy M. Ramos ◽  
D. Nithyadevi ◽  
Rosalie Bordett ◽  
Swetha Rudraiah ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Future Directions ◽  
Functional Biomaterials

Correction for ‘Growing a backbone – functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions’ by Matthew D. Harmon et al., Biomater. Sci., 2020, 8, 1216–1239, DOI: 10.1039/C9BM01288E.

scholarly journals Systematic exploration of the pH dependence of a peptide hydrogel

2019 ◽  
Vol 97 (6) ◽  
pp. 430-434 ◽  
Author(s):  
Natashya Falcone ◽  
Tsuimy Shao ◽  
Xiaoyi Sun ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Mechanical Strength ◽  
Narrow Range ◽  
Ph Dependence ◽  
Stimuli Responsive ◽  
Systematic Exploration ◽  
Ph Conditions ◽  
Ph Dependent ◽  
Functional Biomaterials ◽  
Peptide Hydrogel

Stimuli-responsive peptide gels are a growing class of functional biomaterials that are involved in many applications in research. Here, we present a novel di-peptide hydrogel from the compound Boc–Phe–Trp–OH in various buffer and pH conditions. We examine the effects of different stimuli, including temperature and pH, on the mechanical strength of the gels through frequency rheology studies. We found that this hydrogelator is highly pH dependent, only forming a gel in a narrow range of pH 6–7. This hydrogelator hold promise for the development of new stimuli-responsive biomaterials for specific applications that require this type of specific stimuli.

scholarly journals Rosmarinic Acid and Ulvan from Terrestrial and Marine Sources in Anti-Microbial Bionanosystems and Biomaterials

2021 ◽  
Vol 11 (19) ◽  
pp. 9249
Author(s):  
Serena Coiai ◽  
Beatrice Campanella ◽  
Roberta Paulert ◽  
Francesca Cicogna ◽  
Emilia Bramanti ◽  
...  
Keyword(s):  
Consumer Goods ◽  
Rosmarinic Acid ◽  
Scientific Literature ◽  
Functional Materials ◽  
Present Review ◽  
Terrestrial Plants ◽  
Microbial Polysaccharide ◽  
Inorganic Substrates ◽  
Functional Biomaterials ◽  
Microbial Agent

In order to increase their sustainability, antimicrobial renewable molecules are fundamental additions to consumer goods. Rosmarinic acid is extracted from several terrestrial plants and represents an effective anti-microbial agent. Ulvan, extracted from algae, is an anti-microbial polysaccharide. The present review is dedicated to discussing the sources and the extraction methodologies for obtaining rosmarinic acid and ulvan. Moreover, the preparation of bioanosystems, integrating the two molecules with organic or inorganic substrates, are reviewed as methodologies to increase their effectiveness and stability. Finally, the possibility of preparing functional biomaterials and anti-microbial final products is discussed, considering scientific literature. The performed analysis indicated that the production of both molecules is not yet performed with mature industrial technologies. Nevertheless, both molecules could potentially be used in the packaging, biomedical, pharmaceutical, cosmetic, sanitary and personal care sectors, despite some research being required for developing functional materials with specific properties to pave the way for many more applications.

Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

2019 ◽  
Vol 29 (23) ◽  
pp. 1809009 ◽  
Author(s):  
Xinlong Wang ◽  
Nancy Rivera‐Bolanos ◽  
Bin Jiang ◽  
Guillermo A. Ameer
Keyword(s):  
Stem Cell ◽  
Cell Delivery ◽  
Regenerative Engineering ◽  
Stem Cell Delivery ◽  
Functional Biomaterials

scholarly journals Polymeric sheet actuators with programmable bioinstructivity

2020 ◽  
Vol 117 (4) ◽  
pp. 1895-1901 ◽  
Author(s):  
Zijun Deng ◽  
Weiwei Wang ◽  
Xun Xu ◽  
Oliver E. C. Gould ◽  
Karl Kratz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shape Change ◽  
Cell Lineage ◽  
Fundamental Principle ◽  
Signaling Cascades ◽  
Specific Cell ◽  
Polymer Actuator ◽  
Intracellular Ca ◽  
Functional Biomaterials ◽  
Biochemical Signals

Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSCs). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSCs are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.

scholarly journals Natural Architectures for Tissue Engineering and Regenerative Medicine

2020 ◽  
Vol 11 (3) ◽  
pp. 47
Author(s):  
Floris Honig ◽  
Steven Vermeulen ◽  
Amir A. Zadpoor ◽  
Jan de Boer ◽  
Lidy E. Fratila-Apachitei
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Surface Properties ◽  
State Of The Art ◽  
Cell Behaviour ◽  
Cell Responses ◽  
Underlying Mechanisms ◽  
Functional Biomaterials

The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the holy lotus with special wettability for self-cleaning effects. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses in vitro and provide greater insights into the processes occurring at the cell-biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces, with an emphasis on material properties known to affect cell behaviour.

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