Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

2012 ◽  
Vol 9 (4) ◽  
pp. 385-390 ◽  
Author(s):  
André P Tittel ◽  
Christoph Heuser ◽  
Christina Ohliger ◽  
Chrystel Llanto ◽  
Simon Yona ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

10.1038/90795 ◽  
2001 ◽  
Vol 19 (8) ◽  
pp. 746-750 ◽  
Author(s):  
Michiko Saito ◽  
Takao Iwawaki ◽  
Choji Taya ◽  
Hiromichi Yonekawa ◽  
Munehiro Noda ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Cell Ablation ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice

2015 ◽  
Vol 46 (8) ◽  
pp. 816-828 ◽  
Author(s):  
Ayaka Yanagida ◽  
Naoak Mizuno ◽  
Yuji Yamazaki ◽  
Megumi Kato-Itoh ◽  
Ayumi Umino ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

scholarly journals Monocyte/Macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques

2007 ◽  
Vol 100 (6) ◽  
pp. 884-893 ◽  
Author(s):  
Victoria Stoneman ◽  
Denise Braganza ◽  
Nichola Figg ◽  
John Mercer ◽  
Richard Lang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

scholarly journals Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin

2003 ◽  
Vol 49 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Jeong-Heon Cha ◽  
Mee Young Chang ◽  
James A. Richardson ◽  
Leon Eidels
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

Testicular Cell Selective Ablation Using Diphtheria Toxin Receptor Transgenic Mice

2018 ◽  
pp. 203-228 ◽  
Author(s):  
Diane Rebourcet ◽  
Annalucia Darbey ◽  
Michael Curley ◽  
Peter O’Shaughnessy ◽  
Lee B. Smith
Keyword(s):  
Transgenic Mice ◽  
Diphtheria Toxin ◽  
Testicular Cell ◽  
Diphtheria Toxin Receptor ◽  
Selective Ablation ◽  
Toxin Receptor

scholarly journals CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yosuke Ono ◽  
Osamu Yoshino ◽  
Takehiro Hiraoka ◽  
Erina Sato ◽  
Akiko Furue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Diphtheria Toxin ◽  
Immunohistochemical Study ◽  
Mrna Levels ◽  
Cytokines And Chemokines ◽  
Diphtheria Toxin Receptor ◽  
Endothelial Cell Marker ◽  
Toxin Receptor ◽  
Group A

AbstractIn endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells with diphtheria toxin (DT) in an endometriosis mouse model. The depletion of CD206+ MΦ decreased the total weight of endometriotic-like lesions significantly (p < 0.05). In the endometriotic-like lesions in the DT group, a lower proliferation of endometriotic cells and the decrease of angiogenesis were observed. In the lesions, the mRNA levels of VEGFA and TGFβ1, angiogenic factors, in the DT group significantly decreased to approximately 50% and 30% of control, respectively. Immunohistochemical study revealed the expressions of VEGFA and an endothelial cell marker CD31 in lesions of the DT group, were dim compared to those in control. Also, the number of TGFβ1 expressing MΦ was significantly reduced compared to control. These data suggest that CD206+ MΦ promotes the formation of endometriotic-like lesions by inducing angiogenesis around the lesions.

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

Cell ◽  
1992 ◽  
Vol 69 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Joseph G. Naglich ◽  
James E. Metherall ◽  
David W. Russell ◽  
Leon Eidels
Keyword(s):  
Growth Factor ◽  
Diphtheria Toxin ◽  
Expression Cloning ◽  
Heparin Binding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor
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