Molecular biomimetics: nanotechnology through biology

2003 ◽  
Vol 2 (9) ◽  
pp. 577-585 ◽  
Author(s):  
Mehmet Sarikaya ◽  
Candan Tamerler ◽  
Alex K. -Y. Jen ◽  
Klaus Schulten ◽  
François Baneyx
Keyword(s):  
Molecular Biomimetics

Combinatorial Peptide Libraries for Selecting Inorganic-Binding Proteins: A Step in Molecular Biomimetics

2003 ◽  
Vol 773 ◽  
Author(s):  
C. Tamerler ◽  
S. Dinçer ◽  
D. Heidel ◽  
N. Karagûler ◽  
M. Sarikaya
Keyword(s):  
Binding Proteins ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Inorganic Materials ◽  
Combinatorial Peptide Libraries ◽  
Self Assembling ◽  
Complex Functions ◽  
Recent Developments ◽  
Specific Proteins ◽  
Molecular Biomimetics

AbstractProteins, one of the building blocks in organisms, not only control the assembly in biological systems but also provide most of their complex functions. It may be possible to assemble materials for practical technological applications utilizing the unique advantages provided by proteins. Here we discuss molecular biomimetic pathways in the quest for imitating biology at the molecular scale via protein engineering. We use combinatorial biology protocols to select short polypeptides that have affinity to inorganic materials and use them in assembling novel hybrid materials. We give an overview of some of the recent developments of molecular engineering towards this goal. Inorganic surface specific proteins were identified by using cell surface and phage display technologies. Examples of metal and metal oxide specific polypeptides were represented with an emphasis on certain level of specificities. The recognition and self assembling characteristics of these inorganic-binding proteins would be employed in develeopment of hybrid multifunctional materials for novel bio- and nano-technological applications.

Molecular biomimetics: GEPI-based biological routes to technology

Biopolymers ◽  
2010 ◽  
Vol 94 (1) ◽  
pp. 78-94 ◽  
Author(s):  
Candan Tamerler ◽  
Dmitriy Khatayevich ◽  
Mustafa Gungormus ◽  
Turgay Kacar ◽  
E. Emre Oren ◽  
...  
Keyword(s):  
Molecular Biomimetics

Molecular biomimetics: nanotechnology and bionanotechnology using genetically engineered peptides

2009 ◽  
Vol 367 (1894) ◽  
pp. 1705-1726 ◽  
Author(s):  
Candan Tamerler ◽  
Mehmet Sarikaya
Keyword(s):  
Self Assembly ◽  
Specific Binding ◽  
Hierarchical Structures ◽  
Functional Materials ◽  
Organic Matrix ◽  
Genetically Engineered ◽  
Molecular Engineering ◽  
Inorganic Materials ◽  
Hybrid Functional ◽  
Molecular Biomimetics

Nature provides inspiration for designing materials and systems that derive their functions from highly organized structures. Biological hard tissues are hybrid materials having inorganics within a complex organic matrix, the molecular scaffold controlling the inorganic structures. Biocomposites incorporate both biomacromolecules such as proteins, lipids and polysaccharides, and inorganic materials, such as hydroxyapatite, silica, magnetite and calcite. The ordered organization of hierarchical structures in organisms begins via the molecular recognition of inorganics by proteins that control interactions and is followed by the highly efficient self-assembly across scales. Following the molecular biological principle, proteins could also be used in controlling materials formation in practical engineering via self-assembled, hybrid, functional materials structures. In molecular biomimetics, material-specific peptides could be the key in the molecular engineering of biology-inspired materials. With the recent developments of nanoscale engineering in physical sciences and the advances in molecular biology, we now combine genetic tools with synthetic nanoscale constructs to create a novel methodology. We first genetically select and/or design peptides with specific binding to functional solids, tailor their binding and assembly characteristics, develop bifunctional peptide/protein genetic constructs with both material binding and biological activity, and use these as molecular synthesizers, erectors and assemblers. Here, we give an overview of solid-binding peptides as novel molecular agents coupling bio- and nanotechnology.

scholarly journals Molecular Biomimetics: Genetic Synthesis, Assembly, and Formation of Materials Using Peptides

MRS Bulletin ◽  
2008 ◽  
Vol 33 (5) ◽  
pp. 504-512 ◽  
Author(s):  
Candan Tamerler ◽  
Mehmet Sarikaya
Keyword(s):  
Functional Materials ◽  
Building Blocks ◽  
Recognition Ability ◽  
Practical Engineering ◽  
Specific Affinity ◽  
Binding Peptides ◽  
Molecular Biomimetics ◽  
Combinatorial Mutagenesis ◽  
And Control

AbstractIn nature, the molecular-recognition ability of peptides and, consequently, their functions are evolved through successive cycles of mutation and selection. Using biology as a guide, it is now possible to select, tailor, and control peptide–solid interactions and exploit them in novel ways. Combinatorial mutagenesis provides a protocol to genetically select short peptides with specific affinity to the surfaces of a variety of materials including metals, ceramics, and semiconductors. In the articles of this issue, we describe molecular characterization of inorganic-binding peptides; explain their further tailoring using post-selection genetic engineering and bioinformatics; and finally demonstrate their utility as molecular synthesizers, erectors, and assemblers. The peptides become fundamental building blocks of functional materials, each uniquely designed for an application in areas ranging from practical engineering to medicine.

scholarly journals Synthesis of molecular biomimetics

2015 ◽  
pp. 3-31
Author(s):  
F.T.C. Moreira ◽  
J.R.L. Guerreiro ◽  
L. Brandão ◽  
M.G.F. Sales
Keyword(s):  
Molecular Biomimetics

Biological materials and molecular biomimetics – filling up the empty soft materials space for tissue engineering applications

2015 ◽  
Vol 3 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Ali Miserez ◽  
James C. Weaver ◽  
Ovijit Chaudhuri
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Genetic Characterization ◽  
Molecular Genetic ◽  
Soft Materials ◽  
Biological Materials ◽  
Molecular Biomimetics ◽  
Materials Used ◽  
Molecular Genetic Characterization

The discovery and molecular (genetic) characterization of novel biological materials offers great potential to expand the range of soft materials used for biomedical applications.

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