scholarly journals Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers

2015 ◽  
Vol 14 (11) ◽  
pp. 1164-1171 ◽  
Author(s):  
Felipe García Quiroz ◽  
Ashutosh Chilkoti
Keyword(s):  
Intrinsically Disordered Protein ◽  
Phase Behaviour ◽  
Protein Polymers ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Encode Phase

scholarly journals Dual Self-Assembled Nanostructures from Intrinsically Disordered Protein Polymers with LCST Behavior and Antimicrobial Peptides

2020 ◽  
Vol 21 (10) ◽  
pp. 4043-4052
Author(s):  
Sergio Acosta ◽  
Zhou Ye ◽  
Conrado Aparicio ◽  
Matilde Alonso ◽  
José Carlos Rodríguez-Cabello
Keyword(s):  
Antimicrobial Peptides ◽  
Intrinsically Disordered Protein ◽  
Protein Polymers ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Lcst Behavior ◽  
Self Assembled

Self‐assembling systems comprising intrinsically disordered protein polymers like elastin‐like recombinamers

2021 ◽  
Author(s):  
Diana Juanes‐Gusano ◽  
Mercedes Santos ◽  
Virginia Reboto ◽  
Matilde Alonso ◽  
José Carlos Rodríguez‐Cabello
Keyword(s):  
Intrinsically Disordered Protein ◽  
Protein Polymers ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Self Assembling

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

2018 ◽  
Author(s):  
Sarah Klass ◽  
Matthew J. Smith ◽  
Tahoe Fiala ◽  
Jessica Lee ◽  
Anthony Omole ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fusion Proteins ◽  
Organic Molecules ◽  
Intrinsically Disordered Protein ◽  
Protein Domain ◽  
Enzymatic Cleavage ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Self Assembling ◽  
Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

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